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题名: Chemotaxonomic study of medicinal Taxus species with fingerprint and multivariate analysis
作者: Ge, Guang-Bo1, 2;  Zhang, Yan-Yan1, 2;  Hao, Da-Cheng1, 2;  Hu, Ying1, 2;  Luan, Hong-Wei1, 2;  Liu, Xing-Bao1;  He, Yu-Qi3;  Wang, Zheng-Tao3;  Yang, Ling1
通讯作者: 杨凌
关键词: Taxus ;  Taxaceae ;  chemotaxonomy ;  fingerprinting ;  multivariate analysis ;  taxanes
刊名: PLANTA MEDICA
发表日期: 2008-06-01
DOI: 10.1055/s-2008-1074531
卷: 74, 期:7, 页:773-779
收录类别: SCI
文章类型: Article
部门归属: 18
项目归属: 1806
产权排名: 1;1
WOS标题词: Science & Technology ;  Life Sciences & Biomedicine
类目[WOS]: Plant Sciences ;  Chemistry, Medicinal ;  Pharmacology & Pharmacy
研究领域[WOS]: Plant Sciences ;  Pharmacology & Pharmacy
英文摘要: Species delimitation in Taxus has been controversial and it is very difficult to distinguish yew materials by their morphological characters. In this paper, a valid HPLC fingerprinting method coupled with multivariate analysis was used to define a framework for Taxus species identification and classification. Fingerprint-based similarity was employed for a chemotaxonomic study by hierarchical clustering analysis (HCA) and principal component analysis (PCA). Based on the PCA loadings, twelve chemical constituents were selected as chemotaxonomic markers which can be used to establish a more practical classification. Finally, eight studied species could be divided into six well-supported groups and most samples can be assigned to the correct species. Additionally, twelve markers were tentatively identified by LC/MS.
关键词[WOS]: CHROMATOGRAPHY MASS-SPECTROMETRY ;  LIQUID-CHROMATOGRAPHY ;  WALLICHIANA ;  PACLITAXEL ;  NEEDLES ;  CLASSIFICATION ;  DITERPENOIDS ;  TAXOIDS
语种: 英语
原文出处: 查看原文
WOS记录号: WOS:000257284700013
Citation statistics: 
内容类型: 期刊论文
URI标识: http://cas-ir.dicp.ac.cn/handle/321008/100079
Appears in Collections:中国科学院大连化学物理研究所_期刊论文

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作者单位: 1.Chinese Acad Sci, Lab Pharmaceut Resource Discovery, Dalian Inst Chem Phys, Dalian 116023, Peoples R China
2.Grad Univ Chinese Acad Sci, Beijing, Peoples R China
3.Shanghai Univ Tradit Chinese Med, Key Lab Standardizat Chinese Med, Minist Educ, Shanghai, Peoples R China

Recommended Citation:
Ge, Guang-Bo,Zhang, Yan-Yan,Hao, Da-Cheng,et al. Chemotaxonomic study of medicinal Taxus species with fingerprint and multivariate analysis[J]. PLANTA MEDICA,2008,74(7):773-779.
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