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题名: A novel method of prediction and optimization for preparative high-performance liquid chromatography separation
作者: Jin, Yu1;  Xue, Xingya1;  Liu, Yanfang1;  Xiao, Yuansheng1;  Zhang, Jing1;  Shi, Hui2;  Zhang, Feifang1;  Liang, Xinmiao1, 2
通讯作者: 梁鑫淼
关键词: prediction ;  optimization ;  preparative high-performance liquid chromatography (preparative HPLC) ;  retention equation ;  complex sample ;  traditional Chinese medicine (TCM)
刊名: JOURNAL OF CHROMATOGRAPHY A
发表日期: 2008-03-07
DOI: 10.1016/j.chroma.2008.01.008
卷: 1183, 期:1-2, 页:76-86
收录类别: SCI
文章类型: Article
部门归属: 18
项目归属: 1803
产权排名: 1;1
WOS标题词: Science & Technology ;  Life Sciences & Biomedicine ;  Physical Sciences
类目[WOS]: Biochemical Research Methods ;  Chemistry, Analytical
研究领域[WOS]: Biochemistry & Molecular Biology ;  Chemistry
英文摘要: The preparation of components from a complex sample is a difficult task. The optimization of the separation and subsequent scale-up is usually carried out by trial and error. In this study, the relationship between retention parameters a and c for analytical and preparative separations was developed when the same solid adsorbent and mobile phase were used. The prediction and optimization of the preparative separation of a complex sample could be achieved by direct and simple conversion of the experimentally determined data from an analytical level. The novel method was successfully applied to optimize the separation of target compounds in traditional Chinese medicine (TCM). (C) 2008 Elsevier B.V. All rights reserved.
关键词[WOS]: GRADIENT ELUTION ;  RETENTION TIMES ;  PURIFICATION ;  MODEL
语种: 英语
原文出处: 查看原文
WOS记录号: WOS:000253869900009
Citation statistics: 
内容类型: 期刊论文
URI标识: http://cas-ir.dicp.ac.cn/handle/321008/100093
Appears in Collections:中国科学院大连化学物理研究所_期刊论文

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作者单位: 1.Chinese Acad Sci, Grad Sch, Dalian Inst Chem Phys, Dalian 116023, Peoples R China
2.E China Univ Sci & Technol, Sch Pharm, Shanghai 200237, Peoples R China

Recommended Citation:
Jin, Yu,Xue, Xingya,Liu, Yanfang,et al. A novel method of prediction and optimization for preparative high-performance liquid chromatography separation[J]. JOURNAL OF CHROMATOGRAPHY A,2008,1183(1-2):76-86.
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