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Study on the retention equation in hydrophilic interaction liquid chromatography
Jin, Gaowa; Guo, Zhimou; Zhang, Feifang; Xue, Xingya; Jin, Yu; Liang, Xinmiao; Liang XM(梁鑫淼); Liang XM(梁鑫淼)
KeywordHydrophilic Interaction Liquid Chromatography Retention Equation Stationary Phases Selectivity Nucleoside
Source PublicationTALANTA
2008-07-30
DOI10.1016/j.talanta.2008.03.042
Volume76Issue:3Pages:522-527
Indexed BySCI
SubtypeArticle
Department18
Funding Project1803
Contribution Rank1;1
WOS HeadingsScience & Technology ; Physical Sciences
WOS SubjectChemistry, Analytical
WOS Research AreaChemistry
WOS KeywordELECTROSPRAY MASS-SPECTROMETRY ; LIGHT-SCATTERING DETECTION ; SMALL POLAR COMPOUNDS ; REVERSED-PHASE ; ADRENORECEPTOR AGONISTS ; STATIONARY-PHASE ; DRUG DISCOVERY ; SEPARATION ; SILICA ; PERFORMANCE
AbstractHydrophilic interaction liquid chromatography (HILIC) is an effective technique for separating polar compounds. But its retention equation has not been studied systematically yet. in this study, an appropriate retention equation was established by using eight nucleosides as model analytes and by comparing four retention models on six different HILIC columns. As a result, retention equation In k = a + b x InCB + c x C-B could be quantitatively described the retention factors with good accuracy in HILIC mode. Based on this equation, the retention times of eight nucleosides under the conditions by other mobile phase can be predicted on each column. All of the predicted relative errors of retention times were smaller than 5%. The established retention model was also successfully applied to predict retention times of the real Traditional Chinese Medicine-Carthaus tinctorius L. sample. (C) 2008 Elsevier B.V. All rights reserved.
Language英语
URL查看原文
WOS IDWOS:000257577100006
Citation statistics
Cited Times:107[WOS]   [WOS Record]     [Related Records in WOS]
Document Type期刊论文
Identifierhttp://cas-ir.dicp.ac.cn/handle/321008/100097
Collection中国科学院大连化学物理研究所
Corresponding AuthorLiang XM(梁鑫淼); Liang XM(梁鑫淼)
AffiliationChinese Acad Sci, Dalian Inst Chem Phys, Dalian 116023, Liaoning, Peoples R China
Recommended Citation
GB/T 7714
Jin, Gaowa,Guo, Zhimou,Zhang, Feifang,et al. Study on the retention equation in hydrophilic interaction liquid chromatography[J]. TALANTA,2008,76(3):522-527.
APA Jin, Gaowa.,Guo, Zhimou.,Zhang, Feifang.,Xue, Xingya.,Jin, Yu.,...&梁鑫淼.(2008).Study on the retention equation in hydrophilic interaction liquid chromatography.TALANTA,76(3),522-527.
MLA Jin, Gaowa,et al."Study on the retention equation in hydrophilic interaction liquid chromatography".TALANTA 76.3(2008):522-527.
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