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题名: Study on the retention equation in hydrophilic interaction liquid chromatography
作者: Jin, Gaowa1;  Guo, Zhimou1;  Zhang, Feifang1;  Xue, Xingya1;  Jin, Yu1;  Liang, Xinmiao1
通讯作者: 梁鑫淼
关键词: hydrophilic interaction liquid ;  chromatography ;  retention equation ;  stationary phases ;  selectivity ;  nucleoside
刊名: TALANTA
发表日期: 2008-07-30
DOI: 10.1016/j.talanta.2008.03.042
卷: 76, 期:3, 页:522-527
收录类别: SCI
文章类型: Article
部门归属: 18
项目归属: 1803
产权排名: 1;1
WOS标题词: Science & Technology ;  Physical Sciences
类目[WOS]: Chemistry, Analytical
研究领域[WOS]: Chemistry
英文摘要: Hydrophilic interaction liquid chromatography (HILIC) is an effective technique for separating polar compounds. But its retention equation has not been studied systematically yet. in this study, an appropriate retention equation was established by using eight nucleosides as model analytes and by comparing four retention models on six different HILIC columns. As a result, retention equation In k = a + b x InCB + c x C-B could be quantitatively described the retention factors with good accuracy in HILIC mode. Based on this equation, the retention times of eight nucleosides under the conditions by other mobile phase can be predicted on each column. All of the predicted relative errors of retention times were smaller than 5%. The established retention model was also successfully applied to predict retention times of the real Traditional Chinese Medicine-Carthaus tinctorius L. sample. (C) 2008 Elsevier B.V. All rights reserved.
关键词[WOS]: ELECTROSPRAY MASS-SPECTROMETRY ;  LIGHT-SCATTERING DETECTION ;  SMALL POLAR COMPOUNDS ;  REVERSED-PHASE ;  ADRENORECEPTOR AGONISTS ;  STATIONARY-PHASE ;  DRUG DISCOVERY ;  SEPARATION ;  SILICA ;  PERFORMANCE
语种: 英语
原文出处: 查看原文
WOS记录号: WOS:000257577100006
Citation statistics: 
内容类型: 期刊论文
URI标识: http://cas-ir.dicp.ac.cn/handle/321008/100097
Appears in Collections:中国科学院大连化学物理研究所_期刊论文

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作者单位: 1.Chinese Acad Sci, Dalian Inst Chem Phys, Dalian 116023, Liaoning, Peoples R China

Recommended Citation:
Jin, Gaowa,Guo, Zhimou,Zhang, Feifang,et al. Study on the retention equation in hydrophilic interaction liquid chromatography[J]. TALANTA,2008,76(3):522-527.
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