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题名: Systematic screening and characterization of flavonoid glycosides in Carthamus tinctorius L. by liquid chromatography/UV diode-array detection/electrospray ionization tandem mass spectrometry
作者: Jin, Yu1;  Xiao, Yuan-sheng1;  Zhang, Fei-fang1;  Xue, Xing-ya1;  Xu, Qing1;  Liang, Xin-miao1
通讯作者: 梁鑫淼
关键词: screening ;  characterization ;  flavonoid glycosides ;  Carthamus tinctorius L. ;  HPLC/DAD/ESI-MS"
刊名: JOURNAL OF PHARMACEUTICAL AND BIOMEDICAL ANALYSIS
发表日期: 2008-02-13
DOI: 10.1016/j.jpba.2007.10.036
卷: 46, 期:3, 页:418-430
收录类别: SCI
文章类型: Article
部门归属: 18
项目归属: 1803
产权排名: 1;1
WOS标题词: Science & Technology ;  Physical Sciences ;  Life Sciences & Biomedicine
类目[WOS]: Chemistry, Analytical ;  Pharmacology & Pharmacy
研究领域[WOS]: Chemistry ;  Pharmacology & Pharmacy
英文摘要: The traditional Chinese medicine (TCM) is a complex system, which always consists of numerous compounds with significant difference in the content and physical and chemical properties. In this paper, a screening method based on target molecular weights was developed to characterize the flavonoid glycosides in the flower of Carthamus tinctorius L. The screening tables of aglycone and glycan were designed, respectively, in order to select and combine freely. The multiple reaction monitoring (MRM) scan mode with higher sensitivity and selectivity was adopted in the screening, which benefit the characterization for the minor components. Seventy-seven flavonoid glycosides were screened out finally, and their structures were characterized by tandem mass spectrometric method in both positive and negative ion modes. The glycosylation mode, aglycone, sequence and/or the interglycosidic linkages of the glycan portion and glycosylation position were elucidated by the fragmentation rule in the MS. Numerous compounds screened out with this method showed the structure variety in secondary plant metabolites, and the purposeful screening systemically and subsequent structure characterization offered more information about the chemical constitutions of TCM. (c) 2007 Elsevier B.V. All rights reserved.
关键词[WOS]: ELECTROSPRAY-IONIZATION ;  O-GLYCOSIDES ;  DIFFERENTIATION ;  IDENTIFICATION ;  YELLOW ;  AGLYCONES ;  SAFFLOWER ;  ISOMERS ;  PLANTS ;  PETALS
语种: 英语
原文出处: 查看原文
WOS记录号: WOS:000253100400002
Citation statistics: 
内容类型: 期刊论文
URI标识: http://cas-ir.dicp.ac.cn/handle/321008/100099
Appears in Collections:中国科学院大连化学物理研究所_期刊论文

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作者单位: 1.Chinese Acad Sci, Dalian Inst Chem Phys, Grad Sch, Dalian 116023, Peoples R China

Recommended Citation:
Jin, Yu,Xiao, Yuan-sheng,Zhang, Fei-fang,et al. Systematic screening and characterization of flavonoid glycosides in Carthamus tinctorius L. by liquid chromatography/UV diode-array detection/electrospray ionization tandem mass spectrometry[J]. JOURNAL OF PHARMACEUTICAL AND BIOMEDICAL ANALYSIS,2008,46(3):418-430.
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