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题名: Rapid prediction and optimization of concentration conditions for preparative fractions by solid-phase extraction
作者: Jin, Yu1;  Xue, Xing-ya1;  Zhang, Fei-fang1;  Zhang, Jing1;  Shi, Hui2;  Xiao, Yuan-sheng1;  Ke, Yan-xiong2;  Liang, Xin-miao1, 2
通讯作者: 梁鑫淼
关键词: concentration ;  optimization ;  prediction ;  preparative fractions ;  SPE
刊名: JOURNAL OF SEPARATION SCIENCE
发表日期: 2008-03-01
DOI: 10.1002/jssc.200700477
卷: 31, 期:4, 页:615-621
收录类别: SCI
文章类型: Article
部门归属: 18
项目归属: 1803
产权排名: 1;1
WOS标题词: Science & Technology ;  Physical Sciences
类目[WOS]: Chemistry, Analytical
研究领域[WOS]: Chemistry
英文摘要: SPE is an effective tool for concentrating preparative fractions isolated from a complex sample. To guarantee high efficiency and recovery of concentration, the concentration conditions could be optimized by predicting the breakthrough volume (V-B). In this study, a method of predicting V-B of unknown compounds in preparative fractions at any isocratic mobile phase composition with the analytical retention parameters a and c is described. The a and c values and the relationship between half peak width (W-1/2) and retention time of a model analyte were measured using the analytical elution mode on an SPE column, and the V-B and retention volume (V-R) predicted with the a and c values were validated with breakthrough experiments. However, it is impossible to measure the a and c values of multiple compounds in a complex system directly on an SPE column with a low number of theoretical plates. The correlation of the a and, c values between the SPE and analytical columns was developed so that the analytical data could be transferred to the SPE column. With the calculated a and c values, we could optimize the concentration conditions on the basis of the predicted V-B and the volume of the preparative fraction.
关键词[WOS]: PERFORMANCE LIQUID-CHROMATOGRAPHY ;  POLAR ORGANIC POLLUTANTS ;  GRADIENT ELUTION ;  RETENTION PROPERTIES ;  MASS-SPECTROMETRY ;  TRACE ENRICHMENT ;  AQUEOUS SAMPLES ;  WATER ;  IONIZATION ;  CARTRIDGES
语种: 英语
原文出处: 查看原文
WOS记录号: WOS:000254137900003
Citation statistics: 
内容类型: 期刊论文
URI标识: http://cas-ir.dicp.ac.cn/handle/321008/100101
Appears in Collections:中国科学院大连化学物理研究所_期刊论文

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作者单位: 1.Chinese Acad Sci, Dalian Inst Chem Phys, Grad Sch, Dalian 116023, Peoples R China
2.E China Univ Sci & Technol, Sch Pharm, Shanghai, Peoples R China

Recommended Citation:
Jin, Yu,Xue, Xing-ya,Zhang, Fei-fang,et al. Rapid prediction and optimization of concentration conditions for preparative fractions by solid-phase extraction[J]. JOURNAL OF SEPARATION SCIENCE,2008,31(4):615-621.
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