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题名: Polymethoxylated flavones metabolites in rat plasma after the consumption of Fructus aurantii extract: Analysis by liquid chromatography/electrospray ion trap mass spectrometry
作者: Zhou, Da-Yong1;  Xing, Rong2;  Xu, Qing1;  Xue, Xing-Ya1;  Zhang, Fei-Fang1;  Liang, Xin-Miao1
通讯作者: 梁鑫淼
关键词: LC-MSn ;  polymethoxylated flavones ;  Fructus aurantii ;  rat ;  metabolism
刊名: JOURNAL OF PHARMACEUTICAL AND BIOMEDICAL ANALYSIS
发表日期: 2008-02-13
DOI: 10.1016/j.jpba.2007.11.019
卷: 46, 期:3, 页:543-549
收录类别: SCI
文章类型: Article
部门归属: 18
项目归属: 1803
产权排名: 1;1
WOS标题词: Science & Technology ;  Physical Sciences ;  Life Sciences & Biomedicine
类目[WOS]: Chemistry, Analytical ;  Pharmacology & Pharmacy
研究领域[WOS]: Chemistry ;  Pharmacology & Pharmacy
英文摘要: A LC with full scan MSn method was developed in order to investigate the in vivo absorption and biotransformation of polymethoxylated flavones (PMFs) by analysis of plasma samples from rats after ingestion of Fructus aurantii extract. Four parent compounds and six metabolites with intact flavonoid structures were tentatively identified. The metabolites were either glucuronides of parent compounds or glucuronides of demethylated products of parent compounds. (c) 2007 Elsevier B.V. All rights reserved.
关键词[WOS]: CELL-LINES ;  NOBILETIN ;  BIOTRANSFORMATION ;  IDENTIFICATION ;  ABSORPTION ;  HAMSTERS ;  URINE ;  ARRAY ;  PEEL
语种: 英语
原文出处: 查看原文
WOS记录号: WOS:000253100400016
Citation statistics: 
内容类型: 期刊论文
URI标识: http://cas-ir.dicp.ac.cn/handle/321008/100193
Appears in Collections:中国科学院大连化学物理研究所_期刊论文

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作者单位: 1.Chinese Acad Sci, Dalian Inst Chem Phys, Dalian 116023, Peoples R China
2.Dalinan Med Univ, Dept Pathol Physiol, Dalian 116023, Peoples R China

Recommended Citation:
Zhou, Da-Yong,Xing, Rong,Xu, Qing,et al. Polymethoxylated flavones metabolites in rat plasma after the consumption of Fructus aurantii extract: Analysis by liquid chromatography/electrospray ion trap mass spectrometry[J]. JOURNAL OF PHARMACEUTICAL AND BIOMEDICAL ANALYSIS,2008,46(3):543-549.
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