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Microcalorimetric studies on the antimicrobial actions of different cephalosporins
Yang, L. N.1,2; Xu, F.1; Sun, L. X.1; Zhao, Z. B.3; Song, C. G.4; Xu F(徐芬); Xu F(徐芬)
关键词Cefazolin Sodium Cefonicid Sodium Cephalosporins E. Coli Dh5 Alpha Inhibition Microcalorimetry
刊名JOURNAL OF THERMAL ANALYSIS AND CALORIMETRY
2008-08-01
DOI10.1007/s10973-007-8680-9
93期:2页:417-421
收录类别SCI
文章类型Article
部门归属15,18
项目归属1504,1816
产权排名1;1
WOS标题词Science & Technology ; Physical Sciences
类目[WOS]Chemistry, Analytical ; Chemistry, Physical
研究领域[WOS]Chemistry
关键词[WOS]ESCHERICHIA-COLI DH5-ALPHA ; IN-VITRO ; CEFAZOLIN SODIUM ; DRUG-DELIVERY ; GROWTH ; ANTIBIOTICS ; METABOLISM
英文摘要Microcalorimetry was applied to study the effect of cephalosporins (cefazolin sodium and cefonicid sodium) on the E. coli growth. The microbial activity was recorded as power-time curves through an ampoule method with a TAM Air Isothermal Microcalorimeter at 37 degrees C. The parameters such as the growth rate constant (k), inhibitory ratio (I), the maximum power output (P-m) and the time corresponding to the maximum power output (t(m)) were calculated. The change tendencies of k, with the increasing of concentration (C) of the two cephalosporins, are similar which show that cefazolin sodium and cefonicid sodium have the same inhibitory mechanism. The experimental results reveal that cefonicid sodium has a stronger antibacterial activity towards E. coli than that of cefazolin sodium and this was coincide with the clinical manifestations.
语种英语
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WOS记录号WOS:000258500000012
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被引频次:16[WOS]   [WOS记录]     [WOS相关记录]
文献类型期刊论文
条目标识符http://cas-ir.dicp.ac.cn/handle/321008/100353
专题中国科学院大连化学物理研究所
通讯作者Xu F(徐芬); Xu F(徐芬)
作者单位1.Chinese Acad Sci, Dalian Inst Chem Phys, Mat & Thermochem Lab, Dalian 116023, Peoples R China
2.Chinese Acad Sci, Grad Sch, Beijing 100049, Peoples R China
3.Chinese Acad Sci, Dalian Inst Chem Phys, Div Biotechnol, Dalian 116023, Peoples R China
4.Dalian Inst Drug Detect, Dalian 116021, Peoples R China
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Yang, L. N.,Xu, F.,Sun, L. X.,et al. Microcalorimetric studies on the antimicrobial actions of different cephalosporins[J]. JOURNAL OF THERMAL ANALYSIS AND CALORIMETRY,2008,93(2):417-421.
APA Yang, L. N..,Xu, F..,Sun, L. X..,Zhao, Z. B..,Song, C. G..,...&徐芬.(2008).Microcalorimetric studies on the antimicrobial actions of different cephalosporins.JOURNAL OF THERMAL ANALYSIS AND CALORIMETRY,93(2),417-421.
MLA Yang, L. N.,et al."Microcalorimetric studies on the antimicrobial actions of different cephalosporins".JOURNAL OF THERMAL ANALYSIS AND CALORIMETRY 93.2(2008):417-421.
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