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题名: Microcalorimetric studies on the antimicrobial actions of different cephalosporins
作者: Yang, L. N.1, 2;  Xu, F.1;  Sun, L. X.1;  Zhao, Z. B.3;  Song, C. G.4
通讯作者: 徐芬
关键词: cefazolin sodium ;  cefonicid sodium ;  cephalosporins ;  E. coli DH5 alpha ;  inhibition ;  microcalorimetry
刊名: JOURNAL OF THERMAL ANALYSIS AND CALORIMETRY
发表日期: 2008-08-01
DOI: 10.1007/s10973-007-8680-9
卷: 93, 期:2, 页:417-421
收录类别: SCI
文章类型: Article
部门归属: 15,18
项目归属: 1504,1816
产权排名: 1;1
WOS标题词: Science & Technology ;  Physical Sciences
类目[WOS]: Chemistry, Analytical ;  Chemistry, Physical
研究领域[WOS]: Chemistry
英文摘要: Microcalorimetry was applied to study the effect of cephalosporins (cefazolin sodium and cefonicid sodium) on the E. coli growth. The microbial activity was recorded as power-time curves through an ampoule method with a TAM Air Isothermal Microcalorimeter at 37 degrees C. The parameters such as the growth rate constant (k), inhibitory ratio (I), the maximum power output (P-m) and the time corresponding to the maximum power output (t(m)) were calculated. The change tendencies of k, with the increasing of concentration (C) of the two cephalosporins, are similar which show that cefazolin sodium and cefonicid sodium have the same inhibitory mechanism. The experimental results reveal that cefonicid sodium has a stronger antibacterial activity towards E. coli than that of cefazolin sodium and this was coincide with the clinical manifestations.
关键词[WOS]: ESCHERICHIA-COLI DH5-ALPHA ;  IN-VITRO ;  CEFAZOLIN SODIUM ;  DRUG-DELIVERY ;  GROWTH ;  ANTIBIOTICS ;  METABOLISM
语种: 英语
原文出处: 查看原文
WOS记录号: WOS:000258500000012
Citation statistics: 
内容类型: 期刊论文
URI标识: http://cas-ir.dicp.ac.cn/handle/321008/100353
Appears in Collections:中国科学院大连化学物理研究所_期刊论文

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作者单位: 1.Chinese Acad Sci, Dalian Inst Chem Phys, Mat & Thermochem Lab, Dalian 116023, Peoples R China
2.Chinese Acad Sci, Grad Sch, Beijing 100049, Peoples R China
3.Chinese Acad Sci, Dalian Inst Chem Phys, Div Biotechnol, Dalian 116023, Peoples R China
4.Dalian Inst Drug Detect, Dalian 116021, Peoples R China

Recommended Citation:
Yang, L. N.,Xu, F.,Sun, L. X.,et al. Microcalorimetric studies on the antimicrobial actions of different cephalosporins[J]. JOURNAL OF THERMAL ANALYSIS AND CALORIMETRY,2008,93(2):417-421.
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