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题名: N-3 polyunsaturated fatty acids prevent disruption of epithelial barrier function induced by proinflammatory cytokines
作者: Li, Qiurong1;  Zhang, Qiang1;  Wang, Meng1, 3;  Zhao, Sumin2;  Xu, Guowang2;  Li, Jieshou1
通讯作者: 黎介寿
关键词: n-3 PUFAs ;  lipid composition ;  phospholipids ;  tight junction ;  tight junction proteins
刊名: MOLECULAR IMMUNOLOGY
发表日期: 2008-03-01
DOI: 10.1016/j.molimm.2007.09.003
卷: 45, 期:5, 页:1356-1365
收录类别: SCI
文章类型: Article
部门归属: 18
项目归属: 1808
产权排名: 2;4
WOS标题词: Science & Technology ;  Life Sciences & Biomedicine
类目[WOS]: Biochemistry & Molecular Biology ;  Immunology
研究领域[WOS]: Biochemistry & Molecular Biology ;  Immunology
英文摘要: Defects in tight junction barrier have been considered as an important etiologic factor of Crohn's disease. n-3 polyunsaturated fatty acids (PUFAs) exert beneficial effects on inflammatory bowel disorders. However, the mechanisms remain unknown. We found that docosahexaenoic acid (DHA, 22:6 n-3) and eicosapentaenoic acid (EPA, 20:5 n-3) changed lipid environment in membrane microdomains of tight junction in vitro. n-3 PUFAs treatment effectively prevented the redistribution of occludin and ZO-1 and distortion of TJ morphology, reduced transepithelial electrical resistance induced by IFN-gamma and TNF-alpha. We also observed dramatic reorganization of TJ proteins in epithelial lateral membrane following treatment with these cytokines. Our findings for first time indicate that n-3 PUFAs play an important role in proinflammatory cytokines-induced permeability defects and epithelial barrier dysfunction by modifying lipid environment in membrane microdomains of tight junction. (c) 2007 Elsevier Ltd. All rights reserved.
关键词[WOS]: TIGHT JUNCTION PERMEABILITY ;  INFLAMMATORY-BOWEL-DISEASE ;  TUMOR-NECROSIS-FACTOR ;  CROHNS-DISEASE ;  INTESTINAL PERMEABILITY ;  LIPID-COMPOSITION ;  INTERFERON-GAMMA ;  MEMBRANE RAFTS ;  PROTEINS ;  MECHANISMS
语种: 英语
原文出处: 查看原文
WOS记录号: WOS:000253030000017
Citation statistics: 
内容类型: 期刊论文
URI标识: http://cas-ir.dicp.ac.cn/handle/321008/100425
Appears in Collections:中国科学院大连化学物理研究所_期刊论文

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作者单位: 1.Jinling Hosp, Inst Gen Surg, Nanjing 210002, Peoples R China
2.Chinese Acad Sci, Inst Chem Phys, Natl Chromatog Res & Anal Ctr, Dalian 116011, Peoples R China
3.Nanjing Univ, Sch Med, Nanjing 210093, Peoples R China

Recommended Citation:
Li, Qiurong,Zhang, Qiang,Wang, Meng,et al. N-3 polyunsaturated fatty acids prevent disruption of epithelial barrier function induced by proinflammatory cytokines[J]. MOLECULAR IMMUNOLOGY,2008,45(5):1356-1365.
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