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题名: Metabolic fingerprinting investigation of Artemisia annua L. in different stages of development by gas chromatography and gas chromatography-mass spectrometry
作者: Ma, Chenfei1;  Wang, Huahong2;  Lu, Xin1;  Xu, Guowang1;  Liu, Benye2
通讯作者: 许国旺
关键词: Artemisia annua L. ;  metabolic fingerprinting ;  metabolomics ;  pattern recognition ;  developmental stage
刊名: JOURNAL OF CHROMATOGRAPHY A
发表日期: 2008-04-04
DOI: 10.1016/j.chroma.2007.09.023
卷: 1186, 期:1-2, 页:412-419
收录类别: SCI
文章类型: Article
部门归属: 18
项目归属: 1808
产权排名: 1;1
WOS标题词: Science & Technology ;  Life Sciences & Biomedicine ;  Physical Sciences
类目[WOS]: Biochemical Research Methods ;  Chemistry, Analytical
研究领域[WOS]: Biochemistry & Molecular Biology ;  Chemistry
英文摘要: Artemisia annua L. is an annual herb native of Asia and this plant has been famous for the discovery of the anti-malarial drug artemisinin since 1971. In this work, to investigate variety of whole metabolites, metabolic fingerprinting analysis of A. annua L. was carried out by GC and GC-MS coupled with trimethylsilyl derivatisation. Principal component analysis and partial least squares discriminant analysis were employed to classify GC data of A. annua L. samples at five developmental stages. The results indicated that there was no distinct difference of metabolites between control (001) and transgenic strain (F4) from the tender seedling stage to adult seedling stage, but clear differences were detected at pre-flower budding stage, flower budding stage and full flowering stage. Three precursors of artemisinin biosynthesis were studied at five developmental stages and found that a possible bottleneck exists in the conversion from artemisinic acid or dihydroartemisinic acid to artemisinin. (C) 2007 Elsevier B.V. All rights reserved.
关键词[WOS]: PERFORMANCE LIQUID-CHROMATOGRAPHY ;  DIHYDROARTEMISINIC ACID ;  BIOSYNTHETIC PRECURSORS ;  IDENTIFICATION ;  H-1-NMR ;  PLANTS
语种: 英语
原文出处: 查看原文
WOS记录号: WOS:000254884700036
Citation statistics: 
内容类型: 期刊论文
URI标识: http://cas-ir.dicp.ac.cn/handle/321008/100431
Appears in Collections:中国科学院大连化学物理研究所_期刊论文

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作者单位: 1.Chinese Acad Sci, Dalian Inst Chem Phys, Natl Chromatograph R&A Ctr, Dalian 116023, Peoples R China
2.Chinese Acad Sci, Inst Bot, Beijing 100093, Peoples R China

Recommended Citation:
Ma, Chenfei,Wang, Huahong,Lu, Xin,et al. Metabolic fingerprinting investigation of Artemisia annua L. in different stages of development by gas chromatography and gas chromatography-mass spectrometry[J]. JOURNAL OF CHROMATOGRAPHY A,2008,1186(1-2):412-419.
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