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Metabolic fingerprinting investigation of Artemisia annua L. in different stages of development by gas chromatography and gas chromatography-mass spectrometry
Ma, Chenfei1; Wang, Huahong2; Lu, Xin1; Xu, Guowang1; Liu, Benye2; Xu GW(许国旺)
KeywordArtemisia Annua L. Metabolic Fingerprinting Metabolomics Pattern Recognition Developmental Stage
Source PublicationJOURNAL OF CHROMATOGRAPHY A
2008-04-04
DOI10.1016/j.chroma.2007.09.023
Volume1186Issue:1-2Pages:412-419
Indexed BySCI
SubtypeArticle
Department18
Funding Project1808
Contribution Rank1;1
WOS HeadingsScience & Technology ; Life Sciences & Biomedicine ; Physical Sciences
WOS SubjectBiochemical Research Methods ; Chemistry, Analytical
WOS Research AreaBiochemistry & Molecular Biology ; Chemistry
WOS KeywordPERFORMANCE LIQUID-CHROMATOGRAPHY ; DIHYDROARTEMISINIC ACID ; BIOSYNTHETIC PRECURSORS ; IDENTIFICATION ; H-1-NMR ; PLANTS
AbstractArtemisia annua L. is an annual herb native of Asia and this plant has been famous for the discovery of the anti-malarial drug artemisinin since 1971. In this work, to investigate variety of whole metabolites, metabolic fingerprinting analysis of A. annua L. was carried out by GC and GC-MS coupled with trimethylsilyl derivatisation. Principal component analysis and partial least squares discriminant analysis were employed to classify GC data of A. annua L. samples at five developmental stages. The results indicated that there was no distinct difference of metabolites between control (001) and transgenic strain (F4) from the tender seedling stage to adult seedling stage, but clear differences were detected at pre-flower budding stage, flower budding stage and full flowering stage. Three precursors of artemisinin biosynthesis were studied at five developmental stages and found that a possible bottleneck exists in the conversion from artemisinic acid or dihydroartemisinic acid to artemisinin. (C) 2007 Elsevier B.V. All rights reserved.
Language英语
URL查看原文
WOS IDWOS:000254884700036
Citation statistics
Cited Times:68[WOS]   [WOS Record]     [Related Records in WOS]
Document Type期刊论文
Identifierhttp://cas-ir.dicp.ac.cn/handle/321008/100431
Collection中国科学院大连化学物理研究所
Corresponding AuthorXu GW(许国旺)
Affiliation1.Chinese Acad Sci, Dalian Inst Chem Phys, Natl Chromatograph R&A Ctr, Dalian 116023, Peoples R China
2.Chinese Acad Sci, Inst Bot, Beijing 100093, Peoples R China
Recommended Citation
GB/T 7714
Ma, Chenfei,Wang, Huahong,Lu, Xin,et al. Metabolic fingerprinting investigation of Artemisia annua L. in different stages of development by gas chromatography and gas chromatography-mass spectrometry[J]. JOURNAL OF CHROMATOGRAPHY A,2008,1186(1-2):412-419.
APA Ma, Chenfei,Wang, Huahong,Lu, Xin,Xu, Guowang,Liu, Benye,&许国旺.(2008).Metabolic fingerprinting investigation of Artemisia annua L. in different stages of development by gas chromatography and gas chromatography-mass spectrometry.JOURNAL OF CHROMATOGRAPHY A,1186(1-2),412-419.
MLA Ma, Chenfei,et al."Metabolic fingerprinting investigation of Artemisia annua L. in different stages of development by gas chromatography and gas chromatography-mass spectrometry".JOURNAL OF CHROMATOGRAPHY A 1186.1-2(2008):412-419.
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