DICP OpenIR
Metabonomics study of intestinal transplantation using ultrahigh-performance liquid chromatography time-of-flight mass spectrometry
Li, Qiurong1; Zhang, Qiang1; Xu, Guowang2; Yin, Peiyuan2; Li, Ning1; Li, Jieshou1; Li JS(黎介寿); Li JS(黎介寿)
KeywordMetabonomics Intestinal Transplantation Ultrahigh-performance Liquid Chromatography Time-of-flight Mass Spectrometry Biomarker
Source PublicationDIGESTION
2008
DOI10.1159/000123842
Volume77Issue:2Pages:122-130
Indexed BySCI
SubtypeArticle
Department18
Funding Project1808
Contribution Rank2;3
WOS HeadingsScience & Technology ; Life Sciences & Biomedicine
WOS SubjectGastroenterology & Hepatology
WOS Research AreaGastroenterology & Hepatology
WOS KeywordMAGNETIC-RESONANCE SPECTROSCOPY ; HUMAN LIVER-TRANSPLANTATION ; RENAL-TRANSPLANTATION ; NEPHRECTOMIZED MICE ; REPERFUSION INJURY ; METABOLITES ; REJECTION ; URINE ; RATS ; MS
AbstractBackground: Intestinal transplantation is a potential treatment for patients with irreversible intestinal failure. However, the long-term outcome is still unsatisfactory compared with transplantation of other solid organs because of transplantation rejection. Therefore, early detection and accurate diagnosis of rejection is essential. Recently, metabonomics has become a platform for monitoring of the process of organ transplantation. Methods: The metabolite profiling in the plasma was measured by ultrahigh-performance liquid chromatography time-of-flight mass spectrometry in a patient with intestinal transplantation and it was analyzed by principal component analysis and SIMCA-P. Results: The differences between the patient and controls were achieved in the principal component analysis score plot. The potential biomarkers of rejection, including lysophosphatidyl choline, phenylalanine and tryptophan, were identified in the transplantation patient. Conclusion: The analysis here may provide a fundamental and powerful approach to inspect the disease metabolic status and screening tool for marker candidates. Copyright (C) 2008 S. Karger AG, Basel.
Language英语
URL查看原文
WOS IDWOS:000254893300009
Citation statistics
Cited Times:8[WOS]   [WOS Record]     [Related Records in WOS]
Document Type期刊论文
Identifierhttp://cas-ir.dicp.ac.cn/handle/321008/100439
Collection中国科学院大连化学物理研究所
Corresponding AuthorLi JS(黎介寿); Li JS(黎介寿)
Affiliation1.Jinling Hosp, Inst Gen Surg, Nanjing 210002, Peoples R China
2.Chinese Acad Sci, Dalian Inst Chem Phys, Natl Chromatog Res & Anal Ctr, Dalian, Peoples R China
Recommended Citation
GB/T 7714
Li, Qiurong,Zhang, Qiang,Xu, Guowang,et al. Metabonomics study of intestinal transplantation using ultrahigh-performance liquid chromatography time-of-flight mass spectrometry[J]. DIGESTION,2008,77(2):122-130.
APA Li, Qiurong.,Zhang, Qiang.,Xu, Guowang.,Yin, Peiyuan.,Li, Ning.,...&黎介寿.(2008).Metabonomics study of intestinal transplantation using ultrahigh-performance liquid chromatography time-of-flight mass spectrometry.DIGESTION,77(2),122-130.
MLA Li, Qiurong,et al."Metabonomics study of intestinal transplantation using ultrahigh-performance liquid chromatography time-of-flight mass spectrometry".DIGESTION 77.2(2008):122-130.
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