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Metabonomics study of intestinal transplantation using ultrahigh-performance liquid chromatography time-of-flight mass spectrometry
Li, Qiurong1; Zhang, Qiang1; Xu, Guowang2; Yin, Peiyuan2; Li, Ning1; Li, Jieshou1; Li JS(黎介寿); Li JS(黎介寿)
关键词Metabonomics Intestinal Transplantation Ultrahigh-performance Liquid Chromatography Time-of-flight Mass Spectrometry Biomarker
刊名DIGESTION
2008
DOI10.1159/000123842
77期:2页:122-130
收录类别SCI
文章类型Article
部门归属18
项目归属1808
产权排名2;3
WOS标题词Science & Technology ; Life Sciences & Biomedicine
类目[WOS]Gastroenterology & Hepatology
研究领域[WOS]Gastroenterology & Hepatology
关键词[WOS]MAGNETIC-RESONANCE SPECTROSCOPY ; HUMAN LIVER-TRANSPLANTATION ; RENAL-TRANSPLANTATION ; NEPHRECTOMIZED MICE ; REPERFUSION INJURY ; METABOLITES ; REJECTION ; URINE ; RATS ; MS
英文摘要Background: Intestinal transplantation is a potential treatment for patients with irreversible intestinal failure. However, the long-term outcome is still unsatisfactory compared with transplantation of other solid organs because of transplantation rejection. Therefore, early detection and accurate diagnosis of rejection is essential. Recently, metabonomics has become a platform for monitoring of the process of organ transplantation. Methods: The metabolite profiling in the plasma was measured by ultrahigh-performance liquid chromatography time-of-flight mass spectrometry in a patient with intestinal transplantation and it was analyzed by principal component analysis and SIMCA-P. Results: The differences between the patient and controls were achieved in the principal component analysis score plot. The potential biomarkers of rejection, including lysophosphatidyl choline, phenylalanine and tryptophan, were identified in the transplantation patient. Conclusion: The analysis here may provide a fundamental and powerful approach to inspect the disease metabolic status and screening tool for marker candidates. Copyright (C) 2008 S. Karger AG, Basel.
语种英语
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WOS记录号WOS:000254893300009
引用统计
被引频次:8[WOS]   [WOS记录]     [WOS相关记录]
文献类型期刊论文
条目标识符http://cas-ir.dicp.ac.cn/handle/321008/100439
专题中国科学院大连化学物理研究所
通讯作者Li JS(黎介寿); Li JS(黎介寿)
作者单位1.Jinling Hosp, Inst Gen Surg, Nanjing 210002, Peoples R China
2.Chinese Acad Sci, Dalian Inst Chem Phys, Natl Chromatog Res & Anal Ctr, Dalian, Peoples R China
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GB/T 7714
Li, Qiurong,Zhang, Qiang,Xu, Guowang,et al. Metabonomics study of intestinal transplantation using ultrahigh-performance liquid chromatography time-of-flight mass spectrometry[J]. DIGESTION,2008,77(2):122-130.
APA Li, Qiurong.,Zhang, Qiang.,Xu, Guowang.,Yin, Peiyuan.,Li, Ning.,...&黎介寿.(2008).Metabonomics study of intestinal transplantation using ultrahigh-performance liquid chromatography time-of-flight mass spectrometry.DIGESTION,77(2),122-130.
MLA Li, Qiurong,et al."Metabonomics study of intestinal transplantation using ultrahigh-performance liquid chromatography time-of-flight mass spectrometry".DIGESTION 77.2(2008):122-130.
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