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Simultaneous separation of hydrophilic and hydrophobic compounds by using an online HILIC-RPLC system with two detectors
Wang, Yuan; Lu, Xin; Xu, Guowang; Xu GW(许国旺); Xu GW(许国旺)
关键词Hilic Orthogonality Traditional Chinese Medicine Two-dimensional Liquid Chromatography
刊名JOURNAL OF SEPARATION SCIENCE
2008-05-01
DOI10.1002/jssc.200700663
31期:9页:1564-1572
收录类别SCI
文章类型Article
部门归属18
项目归属1808
产权排名1;1
WOS标题词Science & Technology ; Physical Sciences
类目[WOS]Chemistry, Analytical
研究领域[WOS]Chemistry
关键词[WOS]INTERACTION LIQUID-CHROMATOGRAPHY ; TANDEM MASS-SPECTROMETRY ; LIGHT-SCATTERING DETECTION ; HUMAN PLASMA ; PEPTIDE SEPARATION ; STATIONARY-PHASE ; POLAR COMPOUNDS ; COLUMNS ; GLUTATHIONE ; ACID
英文摘要In the present study, we developed a novel online hydrophilic interaction chromatography (HILIC)-RPLC separation system for simultaneous separation of both hydrophilic and hydrophobic solutes in a complex sample with one injection. A HILIC Si column and a C18 column were hyphenated with an interface including two electronic 2-position valves, a solvent pump, and a solute transfer column. By using column-switching technique, the nonretained hydrophobic solutes were eluted out of the HILIC column and transferred into the C18 column to perform further separation. The hydrophilic solutes were separated on the HILIC column at the same time. One detector was equipped for each column to record the individual chromatograms. By separating a standard mixture and a traditional Chinese medicine (TCM) extract, the developed HILIC-RPLC system demonstrates its potential for "entire-components" separation of complex samples with improved peak capacity and throughput compared with the common single-column LC.
语种英语
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WOS记录号WOS:000256535800014
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被引频次:56[WOS]   [WOS记录]     [WOS相关记录]
文献类型期刊论文
条目标识符http://cas-ir.dicp.ac.cn/handle/321008/100441
专题中国科学院大连化学物理研究所
通讯作者Xu GW(许国旺); Xu GW(许国旺)
作者单位Chinese Acad Sci, Dalian Inst Chem Phys, Natl Chromatog R&A Ctr, Dalian 116023, Peoples R China
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GB/T 7714
Wang, Yuan,Lu, Xin,Xu, Guowang,et al. Simultaneous separation of hydrophilic and hydrophobic compounds by using an online HILIC-RPLC system with two detectors[J]. JOURNAL OF SEPARATION SCIENCE,2008,31(9):1564-1572.
APA Wang, Yuan,Lu, Xin,Xu, Guowang,许国旺,&许国旺.(2008).Simultaneous separation of hydrophilic and hydrophobic compounds by using an online HILIC-RPLC system with two detectors.JOURNAL OF SEPARATION SCIENCE,31(9),1564-1572.
MLA Wang, Yuan,et al."Simultaneous separation of hydrophilic and hydrophobic compounds by using an online HILIC-RPLC system with two detectors".JOURNAL OF SEPARATION SCIENCE 31.9(2008):1564-1572.
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