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题名: Serum metabonomics study of chronic renal failure by ultra performance liquid chromatography coupled with Q-TOF mass spectrometry
作者: Jia, Lewen1, 2;  Chen, Jing1;  Yin, Peiyuan1;  Lu, Xin1;  Xu, Guowang1
通讯作者: 许国旺
关键词: metabonomics ;  UPLC ;  Q TOF MS ;  chronic renal failure ;  biomarker
刊名: METABOLOMICS
发表日期: 2008-06-01
DOI: 10.1007/s11306-008-0110-x
卷: 4, 期:2, 页:183-189
收录类别: SCI
文章类型: Article
部门归属: 18
项目归属: 1808
产权排名: 1;1
WOS标题词: Science & Technology ;  Life Sciences & Biomedicine
类目[WOS]: Endocrinology & Metabolism
研究领域[WOS]: Endocrinology & Metabolism
英文摘要: A metabonomics technique based on ultra-performance liquid chromatography (UPLC) coupled with Q-TOF mass spectrometry was employed to investigate the sera from 32 patients with chronic renal failure (CRF) without renal replacement therapy and 30 healthy volunteers in order to find potential disease biomarkers and reveal its pathophysiological changes. After data acquisition Waters MarkerLynx software was used to report retention time and m/z pairs for each metabolite peak, these data were exported to an excel table, then handled by using multivariate analysis and the statistical analysis in the SIMCA-P and the SPSS softwares to obtain potential biomarkers which were further identified by MS/MS. Seven potential biomarkers, creatinine, tryptophan, phenylalanine, kynurenine and three lysophosphatidylcholines, were identified. The results suggest that CRF can lead to the increase of reservation of creatinine in the body, and the abnormal metabolism of the two essential amino acids and lysophosphatidylcholines. It has indicated that metabonomics will be a powerful tool in the clinic research.
关键词[WOS]: CHRONIC KIDNEY-DISEASE ;  NMR-SPECTROSCOPY ;  INBORN-ERRORS ;  METABOLISM ;  PREVALENCE ;  KYNURENINE ;  BIOMARKERS ;  PATHWAY ;  PLASMA ;  BLOOD
语种: 英语
原文出处: 查看原文
WOS记录号: WOS:000255680200009
Citation statistics: 
内容类型: 期刊论文
URI标识: http://cas-ir.dicp.ac.cn/handle/321008/100443
Appears in Collections:中国科学院大连化学物理研究所_期刊论文

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作者单位: 1.Chinese Acad Sci, Dalian Inst Chem Phys, Natl Chromatog R&A Ctr, Dalian 116023, Peoples R China
2.Dalian Univ Med, Affiliated Hosp 1, Dept Nephrol, Dalian 116011, Peoples R China

Recommended Citation:
Jia, Lewen,Chen, Jing,Yin, Peiyuan,et al. Serum metabonomics study of chronic renal failure by ultra performance liquid chromatography coupled with Q-TOF mass spectrometry[J]. METABOLOMICS,2008,4(2):183-189.
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