DICP OpenIR
Integrated GC-MS and LC-MS plasma metabonomics analysis of ankylosing spondylitis
Gao, Peng2; Lu, Chen1; Zhang, Fengxia2,4; Sang, Ping2,3; Yang, Dawei2,3; Li, Xiang2; Kong, Hongwei2; Yin, Peiyuan2; Tian, Jing2,3; Lu, Xin2; Lu, Aiping1; Xu, Guowang2; Xu GW(许国旺); Xu GW(许国旺)
刊名ANALYST
2008-09-01
DOI10.1039/b807369d
133期:9页:1214-1220
收录类别SCI
文章类型Article
部门归属18
项目归属1808
产权排名1;1
WOS标题词Science & Technology ; Physical Sciences
类目[WOS]Chemistry, Analytical
研究领域[WOS]Chemistry
关键词[WOS]CHROMATOGRAPHY-MASS SPECTROMETRY ; RESEARCH-AND-DEVELOPMENT ; BONE-MINERAL DENSITY ; SYSTEMS BIOLOGY ; METABOLIC INTERACTIONS ; RHEUMATOID-ARTHRITIS ; BIOCHEMICAL MARKERS ; ENDOTHELIAL-CELLS ; GENE-EXPRESSION ; CULTURED HUMAN
英文摘要Ankylosing spondylitis (AS) is a chronic inflammatory arthritis that predominantly affects the axial skeleton in adolescent patients. The natural history of the disease remains poorly characterized. In this study, we combined GC-MS and LC-MS techniques to evaluate the major metabolic changes in the plasma of AS patients in view of metabonomics. Univariate and multivariate analysis were employed for altered metabolite comparison and pattern recognition. Application of supervised partial least-squares discrminant analysis to either GC-MS or LC-MS data allowed accurate discrimination of AS patients from normal controls, demonstrating its potential diagnostic utilization. In addition, AS patients presented elevated plasma concentrations of proline, glucose, phosphate, urea, glycerol, phenylalanine and homocysteine but reduced levels of phosphocholines, tryptophan and a bipeptide - phenylalanyl-phenylalanine. In the context of their involved metabolic pathways, the identified metabolites were discussed accordingly. This investigation primarily proved that integrated chromatography-mass spectrometry and integrated uni- and multi-variate statistical analysis facilitated metabonomics to be a more promising tool in disease research.
语种英语
原文出处查看原文
WOS记录号WOS:000259449400014
引用统计
被引频次:46[WOS]   [WOS记录]     [WOS相关记录]
文献类型期刊论文
条目标识符http://cas-ir.dicp.ac.cn/handle/321008/100453
专题中国科学院大连化学物理研究所
通讯作者Xu GW(许国旺); Xu GW(许国旺)
作者单位1.China Acad Chinese Med Sci, Inst Basic Res Clin Med, Beijing 100700, Peoples R China
2.Chinese Acad Sci, Dalian Inst Chem Phys, Natl Chromatog R&A Ctr, Dalian 116023, Peoples R China
3.Dalian Polytech Univ, Dept Modern Technol, Dalian 116034, Peoples R China
4.Shenyang Pharmaceut Univ, Shenyang 110016, Peoples R China
推荐引用方式
GB/T 7714
Gao, Peng,Lu, Chen,Zhang, Fengxia,et al. Integrated GC-MS and LC-MS plasma metabonomics analysis of ankylosing spondylitis[J]. ANALYST,2008,133(9):1214-1220.
APA Gao, Peng.,Lu, Chen.,Zhang, Fengxia.,Sang, Ping.,Yang, Dawei.,...&许国旺.(2008).Integrated GC-MS and LC-MS plasma metabonomics analysis of ankylosing spondylitis.ANALYST,133(9),1214-1220.
MLA Gao, Peng,et al."Integrated GC-MS and LC-MS plasma metabonomics analysis of ankylosing spondylitis".ANALYST 133.9(2008):1214-1220.
条目包含的文件
条目无相关文件。
个性服务
推荐该条目
保存到收藏夹
查看访问统计
导出为Endnote文件
谷歌学术
谷歌学术中相似的文章
[Gao, Peng]的文章
[Lu, Chen]的文章
[Zhang, Fengxia]的文章
百度学术
百度学术中相似的文章
[Gao, Peng]的文章
[Lu, Chen]的文章
[Zhang, Fengxia]的文章
必应学术
必应学术中相似的文章
[Gao, Peng]的文章
[Lu, Chen]的文章
[Zhang, Fengxia]的文章
相关权益政策
暂无数据
收藏/分享
所有评论 (0)
暂无评论
 

除非特别说明,本系统中所有内容都受版权保护,并保留所有权利。