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题名: Integrated GC-MS and LC-MS plasma metabonomics analysis of ankylosing spondylitis
作者: Gao, Peng2;  Lu, Chen1;  Zhang, Fengxia2, 4;  Sang, Ping2, 3;  Yang, Dawei2, 3;  Li, Xiang2;  Kong, Hongwei2;  Yin, Peiyuan2;  Tian, Jing2, 3;  Lu, Xin2;  Lu, Aiping1;  Xu, Guowang2
通讯作者: 许国旺
刊名: ANALYST
发表日期: 2008-09-01
DOI: 10.1039/b807369d
卷: 133, 期:9, 页:1214-1220
收录类别: SCI
文章类型: Article
部门归属: 18
项目归属: 1808
产权排名: 1;1
WOS标题词: Science & Technology ;  Physical Sciences
类目[WOS]: Chemistry, Analytical
研究领域[WOS]: Chemistry
英文摘要: Ankylosing spondylitis (AS) is a chronic inflammatory arthritis that predominantly affects the axial skeleton in adolescent patients. The natural history of the disease remains poorly characterized. In this study, we combined GC-MS and LC-MS techniques to evaluate the major metabolic changes in the plasma of AS patients in view of metabonomics. Univariate and multivariate analysis were employed for altered metabolite comparison and pattern recognition. Application of supervised partial least-squares discrminant analysis to either GC-MS or LC-MS data allowed accurate discrimination of AS patients from normal controls, demonstrating its potential diagnostic utilization. In addition, AS patients presented elevated plasma concentrations of proline, glucose, phosphate, urea, glycerol, phenylalanine and homocysteine but reduced levels of phosphocholines, tryptophan and a bipeptide - phenylalanyl-phenylalanine. In the context of their involved metabolic pathways, the identified metabolites were discussed accordingly. This investigation primarily proved that integrated chromatography-mass spectrometry and integrated uni- and multi-variate statistical analysis facilitated metabonomics to be a more promising tool in disease research.
关键词[WOS]: CHROMATOGRAPHY-MASS SPECTROMETRY ;  RESEARCH-AND-DEVELOPMENT ;  BONE-MINERAL DENSITY ;  SYSTEMS BIOLOGY ;  METABOLIC INTERACTIONS ;  RHEUMATOID-ARTHRITIS ;  BIOCHEMICAL MARKERS ;  ENDOTHELIAL-CELLS ;  GENE-EXPRESSION ;  CULTURED HUMAN
语种: 英语
原文出处: 查看原文
WOS记录号: WOS:000259449400014
Citation statistics: 
内容类型: 期刊论文
URI标识: http://cas-ir.dicp.ac.cn/handle/321008/100453
Appears in Collections:中国科学院大连化学物理研究所_期刊论文

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作者单位: 1.China Acad Chinese Med Sci, Inst Basic Res Clin Med, Beijing 100700, Peoples R China
2.Chinese Acad Sci, Dalian Inst Chem Phys, Natl Chromatog R&A Ctr, Dalian 116023, Peoples R China
3.Dalian Polytech Univ, Dept Modern Technol, Dalian 116034, Peoples R China
4.Shenyang Pharmaceut Univ, Shenyang 110016, Peoples R China

Recommended Citation:
Gao, Peng,Lu, Chen,Zhang, Fengxia,et al. Integrated GC-MS and LC-MS plasma metabonomics analysis of ankylosing spondylitis[J]. ANALYST,2008,133(9):1214-1220.
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