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题名: Effect of a traditional Chinese medicine preparation Xindi soft capsule on rat model of acute blood stasis: A urinary metabonomics study based on liquid chromatography-mass spectrometry
作者: Zhao, Xinjie;  Zhang, Yi2;  Meng, Xianli2;  Yin, Peiyuan;  Deng, Chong2;  Chen, Jing;  Wang, Zhang2;  Xu, Guowang1
通讯作者: 许国旺
关键词: Sea buckthorn ;  Metabonomics ;  Urine ;  UPLC Q-TOF MS ;  Biomarker ;  Acute blood stasis
刊名: JOURNAL OF CHROMATOGRAPHY B-ANALYTICAL TECHNOLOGIES IN THE BIOMEDICAL AND LIFE SCIENCES
发表日期: 2008-10-01
DOI: 10.1016/j.jchromb.2008.08.010
卷: 873, 期:2, 页:151-158
收录类别: SCI
文章类型: Article
部门归属: 18
项目归属: 1808
产权排名: 1;1
WOS标题词: Science & Technology ;  Life Sciences & Biomedicine ;  Physical Sciences
类目[WOS]: Biochemical Research Methods ;  Chemistry, Analytical
研究领域[WOS]: Biochemistry & Molecular Biology ;  Chemistry
英文摘要: Xindi soft capsule is a traditional Chinese medicine preparation which consists of sea buckthorn flavonoids and sea buckthorn berry oil. In this Study, a urinary metabonomics method based on the ultra-performance liquid chromatography combined with quadrupole time-of-flight tandem mass spectrometry (UPLC Q-TOF MS) was used to evaluate the efficacy and study the mechanism of traditional Chinese medicine preparation to blood stasis. With pattern recognition analysis (principal component analysis and partial least squares-discriminate analysis) Of urinary metabolites, a clear separation of acute blood stasis model group and healthy control group was achieved, the dose groups were located between acute blood stasis model group and healthy control group showing a tendency of recovering to healthy control group, high dose and middle dose were more effective than low dose. Some significantly changed metabolites like cholic acid. phenylalanine and kynurenic acid have been found and identified and used to explain the mechanism. The work shows that the metabonomics method is a valuable tool in the research mechanism of traditional Chinese medicine. (C) 2008 Elsevier B.V. All rights reserved.
关键词[WOS]: MULTIVARIATE STATISTICAL-ANALYSIS ;  HIPPOPHAE-RHAMNOIDES-L ;  UPLC-MS ;  CARDIOVASCULAR-DISEASE ;  PLATELET-AGGREGATION ;  KYNURENINE PATHWAY ;  DISCOVERY ;  METABOLISM ;  DISORDERS ;  RISK
语种: 英语
原文出处: 查看原文
WOS记录号: WOS:000260196000004
Citation statistics: 
内容类型: 期刊论文
URI标识: http://cas-ir.dicp.ac.cn/handle/321008/100461
Appears in Collections:中国科学院大连化学物理研究所_期刊论文

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作者单位: 1.Chinese Acad Sci, Dalian Inst Chem Phys, Natl Chromatog R&A Ctr, Key Lab Separat Sci Analyt Chem, Dalian 116023, Peoples R China
2.Chengdu Univ Tradit Chinese Med, Chengdu 610031, Peoples R China

Recommended Citation:
Zhao, Xinjie,Zhang, Yi,Meng, Xianli,et al. Effect of a traditional Chinese medicine preparation Xindi soft capsule on rat model of acute blood stasis: A urinary metabonomics study based on liquid chromatography-mass spectrometry[J]. JOURNAL OF CHROMATOGRAPHY B-ANALYTICAL TECHNOLOGIES IN THE BIOMEDICAL AND LIFE SCIENCES,2008,873(2):151-158.
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