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题名: Overexpression of hMSH2 and hMLH1 protein in certain gastric cancers and their surrounding mucosae
作者: Li, Mei1;  Liu, Lina2;  Wang, Zhaohui1;  Wang, Lihong1;  Liu, Zhimin1;  Xu, Guowang3;  Lu, Shen1
通讯作者: 吕申
关键词: hMSH2 ;  hMLH1 ;  PCNA ;  Ki67 ;  gastric cancer
刊名: ONCOLOGY REPORTS
发表日期: 2008-02-01
卷: 19, 期:2, 页:401-406
收录类别: SCI
文章类型: Article
部门归属: 18
项目归属: 1808
产权排名: 3;6
WOS标题词: Science & Technology ;  Life Sciences & Biomedicine
类目[WOS]: Oncology
研究领域[WOS]: Oncology
英文摘要: Mismatch repair (MMR) deficiency is closely related to oncogenesis, which is usually accompanied with the loss of expression of hMSH2 and/or hMLH1. These two proteins are detected in many gastric cancers (GCs), and even their overexpression have been reported in certain other cancers. We studied the protein expression levels of MMR (hMSH2 and hMLH1), PCNA and Ki67 in the cancers and surrounding mucosae (SMs) collected from the patients with GC and gastric mucosa samples from non-cancer patients (NCMs), using immunohistochemistry. Our results demonstrated that the positive MMR protein expression levels were 69.1% (132/191), 33.1% (44/133) and 7.1% (3/42) in GCs, SMs and NCMs, respectively (P<0.001); the positive PCNA protein expression levels were 92.1% (176/191), 75.9% (101/133) and 23.8% (10/42), respectively (P<0.001); the positive Ki67 protein expression levels were 79.1% (68/86), 29.2% (21/72) and 45.2% (19/42), respectively (P<0.001). In addition, the MMR protein expression significantly correlated to the level of PCNA protein expression (r(s)=0.170, P=0.019), but not to the level of Ki67 protein expression in GCs. Notably, the overexpression of MMR protein was not correlated to either PCNA or Ki67 protein expression in SMs and NCMs. These results support the evidence that MMR protein expression may increase prior to gastric cancer occurrence, and in a view of early diagnosis, the detection of MMR protein by IHC may be helpful as a marker in early prediction of gastric cancer.
关键词[WOS]: DNA MISMATCH REPAIR ;  NONPOLYPOSIS COLORECTAL-CANCER ;  MICROSATELLITE INSTABILITY ;  GENE HMSH2 ;  EXPRESSION ;  CARCINOMA ;  PROMOTER ;  DEFECTS ;  CYCLE
语种: 英语
原文出处: 查看原文
WOS记录号: WOS:000252648600013
Citation statistics: 
内容类型: 期刊论文
URI标识: http://cas-ir.dicp.ac.cn/handle/321008/100481
Appears in Collections:中国科学院大连化学物理研究所_期刊论文

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作者单位: 1.Dalian Med Univ, Affiliated Hosp 2, Lab Ctr, Dalian 116027, Liaoning Prov, Peoples R China
2.Dalian Med Univ, First Hosp, Dept Gastroenterol, Dalian 116011, Peoples R China
3.Chinese Acad Sci, Dalian Inst Chem Phys, Natl Chromatog Res & Applicat Ctr, Dalian 116027, Liaoning Prov, Peoples R China

Recommended Citation:
Li, Mei,Liu, Lina,Wang, Zhaohui,et al. Overexpression of hMSH2 and hMLH1 protein in certain gastric cancers and their surrounding mucosae[J]. ONCOLOGY REPORTS,2008,19(2):401-406.
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