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题名: Identification of major xanthones and steroidal saponins in rat urine by liquid chromatography-atmospheric pressure chemical ionization mass spectrometry technology following oral administration of Rhizoma Anemarrhenae decoction
作者: Ma, Chunhui1;  Wang, Longxing2;  Tang, Yihong1;  Fan, Mingsong1;  Xia, Hongbin2;  Huang, Chenggang1
通讯作者: Chenggang Huang
关键词: Rhizoma Anemarrhenae ;  Anemarrhena asphodeloides ;  xanthone ;  steroidal saponin ;  urine
刊名: BIOMEDICAL CHROMATOGRAPHY
发表日期: 2008-10-01
DOI: 10.1002/bmc.1026
卷: 22, 期:10, 页:1066-1083
收录类别: SCI
文章类型: Article
部门归属: 18
项目归属: 1804
产权排名: 2;2
WOS标题词: Science & Technology ;  Life Sciences & Biomedicine ;  Physical Sciences
类目[WOS]: Biochemical Research Methods ;  Biochemistry & Molecular Biology ;  Chemistry, Analytical ;  Pharmacology & Pharmacy
研究领域[WOS]: Biochemistry & Molecular Biology ;  Chemistry ;  Pharmacology & Pharmacy
英文摘要: Rhizoma Anemarrhenae (Zhimu in Chinese), the dried rhizome of Anemarrhena asphodeloides Bge. (Fam. Liliaceae), is a well-known traditional Chinese medicinal herb and has been used clinically in China for centuries to cure various diseases. However, like other traditional Chinese medicines, the effective constituents of this medicine, especially the assimilation and metabolites in vivo, which are very important to show their effects, have not been systematically studied. In this paper, solid-phase extraction and liquid chromatography-atmospheric pressure chemical ionization mass spectrometry technologies were used to study the constituents absorbed into rat urine and their metabolites after oral administration of Rhizoma Anemarrhenae decoction. A total of 11 compounds, including two xanthones, three of their metabolites and six steroidal saponins, were identified in rat urine sample. They were neomangiferin (1), glucuronide and monomethyl conjugate of mangiferin (2), mangiferin (3), monomethyl conjugate of mangiferin (4), dimethyl conjugate of mangiferin (5), timosaponin N or timosaponin E1 (6), timosaponin 1311 (7), timosaponin BIII (8), anemarrhenasaponin I or anemarrhenasaponin II (9), timosaponin AII (10) and timosaponin AIII (11). The results would efficaciously narrow the potentially active compounds range in Rhizoma Anemarrhenae decoction, and pave a helpful way for follow-up mechanism of action research. Copyright (C) 2008 John Wiley & Sons, Ltd.
关键词[WOS]: ASPHODELOIDES BUNGE LILIACEAE ;  SUPEROXIDE GENERATION ;  LC-MS/MS ;  PLATELET-AGGREGATION ;  HUMAN NEUTROPHILS ;  HUMAN BLOOD ;  METABOLITES ;  MANGIFERIN ;  EXTRACT ;  MS
语种: 英语
原文出处: 查看原文
WOS记录号: WOS:000260522400004
Citation statistics: 
内容类型: 期刊论文
URI标识: http://cas-ir.dicp.ac.cn/handle/321008/100801
Appears in Collections:中国科学院大连化学物理研究所_期刊论文

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作者单位: 1.Chinese Acad Sci, Shanghai Inst Biol Sci, Shanghai Inst Mat Med, Shanghai 201203, Peoples R China
2.Chinese Acad Sci, Dalian Inst Chem Phys, Med Chem Lab, Dalian 116023, Peoples R China

Recommended Citation:
Ma, Chunhui,Wang, Longxing,Tang, Yihong,et al. Identification of major xanthones and steroidal saponins in rat urine by liquid chromatography-atmospheric pressure chemical ionization mass spectrometry technology following oral administration of Rhizoma Anemarrhenae decoction[J]. BIOMEDICAL CHROMATOGRAPHY,2008,22(10):1066-1083.
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