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题名: Selective growth inhibition of human leukemia and human lymphoblastoid cells by resveratrol via cell cycle arrest and apoptosis induction
作者: Lee, Sau K.1;  Zhang, Wei1, 2;  Sanderson, Barbara J. S.1
通讯作者: SAU K.LEE
关键词: resveratrol ;  chemopreventive ;  cell cycle ;  apoptosis ;  reversible
刊名: JOURNAL OF AGRICULTURAL AND FOOD CHEMISTRY
发表日期: 2008-08-27
DOI: 10.1021/jf801014p
卷: 56, 期:16, 页:7572-7577
收录类别: SCI
文章类型: Article
部门归属: 18
项目归属: 1812
产权排名: 2;2
WOS标题词: Science & Technology ;  Life Sciences & Biomedicine ;  Physical Sciences
类目[WOS]: Agriculture, Multidisciplinary ;  Chemistry, Applied ;  Food Science & Technology
研究领域[WOS]: Agriculture ;  Chemistry ;  Food Science & Technology
英文摘要: There is great interest in the potential chemopreventive activity of resveratrol against human cancers. However, there are conflicting results on its growth inhibitory effect on normal cells. This project examined the differential effect of resveratrol at physiologically relevant concentrations on nonmalignant (WIL2-NS) and malignant (HL-60) cell lines and compared the underlying mechanisms via cell cycle modulation, apoptosis induction, and genotoxicity potential. Twenty-four hours of exposure to resveratrol was toxic to WIL2-NS and HL-60 cells in a dose-dependent manner. WIL2-NS cells regrew 5 times more than HL-60 cells by 120 h after the removal of 100 mu M resveratrol (p < 0.05). Furthermore, significant alterations in cell cycle kinetics were induced by resveratrol in HL-60 cells, but were to a lesser extent for WIL2-NS cells. The proportion of apoptosis was also 3 times higher in HL-60 cells as compared to WIL2-NS cells for 100 mu M resveratrol (p < 0.05). In conclusion, resveratrol preferentially inhibited the growth of HL-60 cells via cell cycle modulation and apoptosis induction and subsequently directed the cells to irreversible cell death, whereas the effect on WIL2-NS cells was largely reversible.
关键词[WOS]: SMOOTH-MUSCLE-CELLS ;  S-PHASE ;  ASSAY ;  MECHANISMS ;  CULTURES ;  GRAPES ;  AGENT ;  BLOCK
语种: 英语
原文出处: 查看原文
WOS记录号: WOS:000258633700115
Citation statistics: 
内容类型: 期刊论文
URI标识: http://cas-ir.dicp.ac.cn/handle/321008/100807
Appears in Collections:中国科学院大连化学物理研究所_期刊论文

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作者单位: 1.Flinders Univ S Australia, Sch Med, Dept Med Biotechnol, Adelaide, SA 5001, Australia
2.Chinese Acad Sci, Dalian Inst Chem Phys, Marine Bioprod Engn Grp, Dalian 116023, Peoples R China

Recommended Citation:
Lee, Sau K.,Zhang, Wei,Sanderson, Barbara J. S.. Selective growth inhibition of human leukemia and human lymphoblastoid cells by resveratrol via cell cycle arrest and apoptosis induction[J]. JOURNAL OF AGRICULTURAL AND FOOD CHEMISTRY,2008,56(16):7572-7577.
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