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Selective growth inhibition of human leukemia and human lymphoblastoid cells by resveratrol via cell cycle arrest and apoptosis induction
Lee, Sau K.1; Zhang, Wei1,2; Sanderson, Barbara J. S.1; SAU K.LEE; SAU K.LEE
关键词Resveratrol Chemopreventive Cell Cycle Apoptosis Reversible
刊名JOURNAL OF AGRICULTURAL AND FOOD CHEMISTRY
2008-08-27
DOI10.1021/jf801014p
56期:16页:7572-7577
收录类别SCI
文章类型Article
部门归属18
项目归属1812
产权排名2;2
WOS标题词Science & Technology ; Life Sciences & Biomedicine ; Physical Sciences
类目[WOS]Agriculture, Multidisciplinary ; Chemistry, Applied ; Food Science & Technology
研究领域[WOS]Agriculture ; Chemistry ; Food Science & Technology
关键词[WOS]SMOOTH-MUSCLE-CELLS ; S-PHASE ; ASSAY ; MECHANISMS ; CULTURES ; GRAPES ; AGENT ; BLOCK
英文摘要There is great interest in the potential chemopreventive activity of resveratrol against human cancers. However, there are conflicting results on its growth inhibitory effect on normal cells. This project examined the differential effect of resveratrol at physiologically relevant concentrations on nonmalignant (WIL2-NS) and malignant (HL-60) cell lines and compared the underlying mechanisms via cell cycle modulation, apoptosis induction, and genotoxicity potential. Twenty-four hours of exposure to resveratrol was toxic to WIL2-NS and HL-60 cells in a dose-dependent manner. WIL2-NS cells regrew 5 times more than HL-60 cells by 120 h after the removal of 100 mu M resveratrol (p < 0.05). Furthermore, significant alterations in cell cycle kinetics were induced by resveratrol in HL-60 cells, but were to a lesser extent for WIL2-NS cells. The proportion of apoptosis was also 3 times higher in HL-60 cells as compared to WIL2-NS cells for 100 mu M resveratrol (p < 0.05). In conclusion, resveratrol preferentially inhibited the growth of HL-60 cells via cell cycle modulation and apoptosis induction and subsequently directed the cells to irreversible cell death, whereas the effect on WIL2-NS cells was largely reversible.
语种英语
原文出处查看原文
WOS记录号WOS:000258633700115
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被引频次:35[WOS]   [WOS记录]     [WOS相关记录]
文献类型期刊论文
条目标识符http://cas-ir.dicp.ac.cn/handle/321008/100807
专题中国科学院大连化学物理研究所
通讯作者SAU K.LEE; SAU K.LEE
作者单位1.Flinders Univ S Australia, Sch Med, Dept Med Biotechnol, Adelaide, SA 5001, Australia
2.Chinese Acad Sci, Dalian Inst Chem Phys, Marine Bioprod Engn Grp, Dalian 116023, Peoples R China
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GB/T 7714
Lee, Sau K.,Zhang, Wei,Sanderson, Barbara J. S.,et al. Selective growth inhibition of human leukemia and human lymphoblastoid cells by resveratrol via cell cycle arrest and apoptosis induction[J]. JOURNAL OF AGRICULTURAL AND FOOD CHEMISTRY,2008,56(16):7572-7577.
APA Lee, Sau K.,Zhang, Wei,Sanderson, Barbara J. S.,SAU K.LEE,&SAU K.LEE.(2008).Selective growth inhibition of human leukemia and human lymphoblastoid cells by resveratrol via cell cycle arrest and apoptosis induction.JOURNAL OF AGRICULTURAL AND FOOD CHEMISTRY,56(16),7572-7577.
MLA Lee, Sau K.,et al."Selective growth inhibition of human leukemia and human lymphoblastoid cells by resveratrol via cell cycle arrest and apoptosis induction".JOURNAL OF AGRICULTURAL AND FOOD CHEMISTRY 56.16(2008):7572-7577.
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