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Selective growth inhibition of human leukemia and human lymphoblastoid cells by resveratrol via cell cycle arrest and apoptosis induction
Lee, Sau K.1; Zhang, Wei1,2; Sanderson, Barbara J. S.1; SAU K.LEE; SAU K.LEE
KeywordResveratrol Chemopreventive Cell Cycle Apoptosis Reversible
Source PublicationJOURNAL OF AGRICULTURAL AND FOOD CHEMISTRY
2008-08-27
DOI10.1021/jf801014p
Volume56Issue:16Pages:7572-7577
Indexed BySCI
SubtypeArticle
Department18
Funding Project1812
Contribution Rank2;2
WOS HeadingsScience & Technology ; Life Sciences & Biomedicine ; Physical Sciences
WOS SubjectAgriculture, Multidisciplinary ; Chemistry, Applied ; Food Science & Technology
WOS Research AreaAgriculture ; Chemistry ; Food Science & Technology
WOS KeywordSMOOTH-MUSCLE-CELLS ; S-PHASE ; ASSAY ; MECHANISMS ; CULTURES ; GRAPES ; AGENT ; BLOCK
AbstractThere is great interest in the potential chemopreventive activity of resveratrol against human cancers. However, there are conflicting results on its growth inhibitory effect on normal cells. This project examined the differential effect of resveratrol at physiologically relevant concentrations on nonmalignant (WIL2-NS) and malignant (HL-60) cell lines and compared the underlying mechanisms via cell cycle modulation, apoptosis induction, and genotoxicity potential. Twenty-four hours of exposure to resveratrol was toxic to WIL2-NS and HL-60 cells in a dose-dependent manner. WIL2-NS cells regrew 5 times more than HL-60 cells by 120 h after the removal of 100 mu M resveratrol (p < 0.05). Furthermore, significant alterations in cell cycle kinetics were induced by resveratrol in HL-60 cells, but were to a lesser extent for WIL2-NS cells. The proportion of apoptosis was also 3 times higher in HL-60 cells as compared to WIL2-NS cells for 100 mu M resveratrol (p < 0.05). In conclusion, resveratrol preferentially inhibited the growth of HL-60 cells via cell cycle modulation and apoptosis induction and subsequently directed the cells to irreversible cell death, whereas the effect on WIL2-NS cells was largely reversible.
Language英语
URL查看原文
WOS IDWOS:000258633700115
Citation statistics
Cited Times:36[WOS]   [WOS Record]     [Related Records in WOS]
Document Type期刊论文
Identifierhttp://cas-ir.dicp.ac.cn/handle/321008/100807
Collection中国科学院大连化学物理研究所
Corresponding AuthorSAU K.LEE; SAU K.LEE
Affiliation1.Flinders Univ S Australia, Sch Med, Dept Med Biotechnol, Adelaide, SA 5001, Australia
2.Chinese Acad Sci, Dalian Inst Chem Phys, Marine Bioprod Engn Grp, Dalian 116023, Peoples R China
Recommended Citation
GB/T 7714
Lee, Sau K.,Zhang, Wei,Sanderson, Barbara J. S.,et al. Selective growth inhibition of human leukemia and human lymphoblastoid cells by resveratrol via cell cycle arrest and apoptosis induction[J]. JOURNAL OF AGRICULTURAL AND FOOD CHEMISTRY,2008,56(16):7572-7577.
APA Lee, Sau K.,Zhang, Wei,Sanderson, Barbara J. S.,SAU K.LEE,&SAU K.LEE.(2008).Selective growth inhibition of human leukemia and human lymphoblastoid cells by resveratrol via cell cycle arrest and apoptosis induction.JOURNAL OF AGRICULTURAL AND FOOD CHEMISTRY,56(16),7572-7577.
MLA Lee, Sau K.,et al."Selective growth inhibition of human leukemia and human lymphoblastoid cells by resveratrol via cell cycle arrest and apoptosis induction".JOURNAL OF AGRICULTURAL AND FOOD CHEMISTRY 56.16(2008):7572-7577.
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