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题名: Anti-angiogenic activities of chitooligosaccharides
作者: Wu, Haige1, 2, 3;  Yao, Ziang2;  Bal, Xuefang1;  Du, Yuguang1;  Lin, Bingcheng1
通讯作者: 杜昱光
关键词: chitoologosaccharides ;  endothelial cell ;  CAM ;  angiogenesis
刊名: CARBOHYDRATE POLYMERS
发表日期: 2008-07-04
DOI: 10.1016/j.carbpol.2007.11.011
卷: 73, 期:1, 页:105-110
收录类别: SCI
文章类型: Article
部门归属: 18
项目归属: 1805,1807
产权排名: 1;1
WOS标题词: Science & Technology ;  Physical Sciences
类目[WOS]: Chemistry, Applied ;  Chemistry, Organic ;  Polymer Science
研究领域[WOS]: Chemistry ;  Polymer Science
英文摘要: Chitooligosaccharides (COS) was obtained from chitosan by depolymerization with enzyme and analyzed by HPLC and TOF-MS, and the results indicated that the polymerization degree of COS was 2-18. In order to explore the anti-angiogenic activities of COS, the effect of COS on chicken chorioallantoic membrane (CAM) angiogenesis and on proliferation, migration and tube formation of human umbilical vein endothelial cells (HUVECs) induced by human hepatoma carcinoma cells (HCC) culture fluid was measured. The results showed COS had no toxicity to normal HUVECs, but could inhibit the CAM angiogenesis and the proliferation, migration and tube formation of induced HUVECs. All of these results indicate that COS have potential anti-angiogenic activities and can counteract the stimulation of HCC-culture-fluid on endothelial cells at a certain level. (C) 2007 Elsevier Ltd. All rights reserved.
关键词[WOS]: CANCER ;  METALLOPROTEINASES ;  STRATEGIES ;  CHITOSAN ;  GROWTH ;  CELLS
语种: 英语
原文出处: 查看原文
WOS记录号: WOS:000255450200013
Citation statistics: 
内容类型: 期刊论文
URI标识: http://cas-ir.dicp.ac.cn/handle/321008/101043
Appears in Collections:中国科学院大连化学物理研究所_期刊论文

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作者单位: 1.Chinese Acad Sci, Dalian Inst Chem Phys, Dalian 116023, Peoples R China
2.Dalian Univ, Bioengn Coll, Dalian 116622, Peoples R China
3.Chinese Acad Sci, Grad Sch, Beijing 100049, Peoples R China

Recommended Citation:
Wu, Haige,Yao, Ziang,Bal, Xuefang,et al. Anti-angiogenic activities of chitooligosaccharides[J]. CARBOHYDRATE POLYMERS,2008,73(1):105-110.
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