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Anti-angiogenic activities of chitooligosaccharides
Wu, Haige1,2,3; Yao, Ziang2; Bal, Xuefang1; Du, Yuguang1; Lin, Bingcheng1; Du YG(杜昱光); Du YG(杜昱光)
关键词Chitoologosaccharides Endothelial Cell Cam Angiogenesis
刊名CARBOHYDRATE POLYMERS
2008-07-04
ISSNISSN: 0144-8617
DOI10.1016/j.carbpol.2007.11.011
73期:1页:105-110
收录类别SCI
文章类型Article
部门归属18
项目归属1805,1807
产权排名1;1
WOS标题词Science & Technology ; Physical Sciences
类目[WOS]Chemistry, Applied ; Chemistry, Organic ; Polymer Science
研究领域[WOS]Chemistry ; Polymer Science
关键词[WOS]CANCER ; METALLOPROTEINASES ; STRATEGIES ; CHITOSAN ; GROWTH ; CELLS
英文摘要Chitooligosaccharides (COS) was obtained from chitosan by depolymerization with enzyme and analyzed by HPLC and TOF-MS, and the results indicated that the polymerization degree of COS was 2-18. In order to explore the anti-angiogenic activities of COS, the effect of COS on chicken chorioallantoic membrane (CAM) angiogenesis and on proliferation, migration and tube formation of human umbilical vein endothelial cells (HUVECs) induced by human hepatoma carcinoma cells (HCC) culture fluid was measured. The results showed COS had no toxicity to normal HUVECs, but could inhibit the CAM angiogenesis and the proliferation, migration and tube formation of induced HUVECs. All of these results indicate that COS have potential anti-angiogenic activities and can counteract the stimulation of HCC-culture-fluid on endothelial cells at a certain level. (C) 2007 Elsevier Ltd. All rights reserved.
语种英语
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WOS记录号WOS:000255450200013
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被引频次:26[WOS]   [WOS记录]     [WOS相关记录]
文献类型期刊论文
条目标识符http://cas-ir.dicp.ac.cn/handle/321008/101043
专题中国科学院大连化学物理研究所
通讯作者Du YG(杜昱光); Du YG(杜昱光)
作者单位1.Chinese Acad Sci, Dalian Inst Chem Phys, Dalian 116023, Peoples R China
2.Dalian Univ, Bioengn Coll, Dalian 116622, Peoples R China
3.Chinese Acad Sci, Grad Sch, Beijing 100049, Peoples R China
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GB/T 7714
Wu, Haige,Yao, Ziang,Bal, Xuefang,et al. Anti-angiogenic activities of chitooligosaccharides[J]. CARBOHYDRATE POLYMERS,2008,73(1):105-110.
APA Wu, Haige.,Yao, Ziang.,Bal, Xuefang.,Du, Yuguang.,Lin, Bingcheng.,...&杜昱光.(2008).Anti-angiogenic activities of chitooligosaccharides.CARBOHYDRATE POLYMERS,73(1),105-110.
MLA Wu, Haige,et al."Anti-angiogenic activities of chitooligosaccharides".CARBOHYDRATE POLYMERS 73.1(2008):105-110.
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