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Anti-angiogenic activities of chitooligosaccharides
Wu, Haige1,2,3; Yao, Ziang2; Bal, Xuefang1; Du, Yuguang1; Lin, Bingcheng1; Du YG(杜昱光); Du YG(杜昱光)
KeywordChitoologosaccharides Endothelial Cell Cam Angiogenesis
Source PublicationCARBOHYDRATE POLYMERS
2008-07-04
ISSNISSN: 0144-8617
DOI10.1016/j.carbpol.2007.11.011
Volume73Issue:1Pages:105-110
Indexed BySCI
SubtypeArticle
Department18
Funding Project1805,1807
Contribution Rank1;1
WOS HeadingsScience & Technology ; Physical Sciences
WOS SubjectChemistry, Applied ; Chemistry, Organic ; Polymer Science
WOS Research AreaChemistry ; Polymer Science
WOS KeywordCANCER ; METALLOPROTEINASES ; STRATEGIES ; CHITOSAN ; GROWTH ; CELLS
AbstractChitooligosaccharides (COS) was obtained from chitosan by depolymerization with enzyme and analyzed by HPLC and TOF-MS, and the results indicated that the polymerization degree of COS was 2-18. In order to explore the anti-angiogenic activities of COS, the effect of COS on chicken chorioallantoic membrane (CAM) angiogenesis and on proliferation, migration and tube formation of human umbilical vein endothelial cells (HUVECs) induced by human hepatoma carcinoma cells (HCC) culture fluid was measured. The results showed COS had no toxicity to normal HUVECs, but could inhibit the CAM angiogenesis and the proliferation, migration and tube formation of induced HUVECs. All of these results indicate that COS have potential anti-angiogenic activities and can counteract the stimulation of HCC-culture-fluid on endothelial cells at a certain level. (C) 2007 Elsevier Ltd. All rights reserved.
Language英语
URL查看原文
WOS IDWOS:000255450200013
Citation statistics
Cited Times:27[WOS]   [WOS Record]     [Related Records in WOS]
Document Type期刊论文
Identifierhttp://cas-ir.dicp.ac.cn/handle/321008/101043
Collection中国科学院大连化学物理研究所
Corresponding AuthorDu YG(杜昱光); Du YG(杜昱光)
Affiliation1.Chinese Acad Sci, Dalian Inst Chem Phys, Dalian 116023, Peoples R China
2.Dalian Univ, Bioengn Coll, Dalian 116622, Peoples R China
3.Chinese Acad Sci, Grad Sch, Beijing 100049, Peoples R China
Recommended Citation
GB/T 7714
Wu, Haige,Yao, Ziang,Bal, Xuefang,et al. Anti-angiogenic activities of chitooligosaccharides[J]. CARBOHYDRATE POLYMERS,2008,73(1):105-110.
APA Wu, Haige.,Yao, Ziang.,Bal, Xuefang.,Du, Yuguang.,Lin, Bingcheng.,...&杜昱光.(2008).Anti-angiogenic activities of chitooligosaccharides.CARBOHYDRATE POLYMERS,73(1),105-110.
MLA Wu, Haige,et al."Anti-angiogenic activities of chitooligosaccharides".CARBOHYDRATE POLYMERS 73.1(2008):105-110.
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