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题名: Effects of chitosan oligosaccharides on neutrophils from glycogen-induced peritonitis mice model
作者: Dou, Jiangli1, 2;  Xu, Qingsong1, 2;  Tan, Chengyu1;  Wang, Wenxia1, 2;  Du, Yuguang1;  Bai, Xuefang1;  Ma, Xiaojun1
通讯作者: 杜昱光
关键词: Chitosan oligosaccharides ;  Neutrophil ;  Superoxide ;  Apoptosis ;  Inflammation
刊名: CARBOHYDRATE POLYMERS
发表日期: 2009-01-05
DOI: 10.1016/j.carbpol.2008.07.005
卷: 75, 期:1, 页:119-124
收录类别: SCI
文章类型: Article
部门归属: 18
项目归属: 1805,1802
产权排名: 1;1
WOS标题词: Science & Technology ;  Physical Sciences
类目[WOS]: Chemistry, Applied ;  Chemistry, Organic ;  Polymer Science
研究领域[WOS]: Chemistry ;  Polymer Science
英文摘要: To investigate the effects of chitosan oligosaccharides (COS) on the neutrophils from glycogen-induced peritonitis mice model, the production of superoxide and hydrogen peroxide, myeloperoxidase (MPO) release as well as apoptosis were measured. We found that 100 mu g/ml COS supplementation could induce the production of superoxide and hydrogen peroxide by neutrophils, meanwhile, COS promoted the apoptosis of peritoneal neutrophils, whereas the MPO release was decreased. Furthermore, superoxide dismutase (SOD) administration could abolish the pro-apoptotic effects mediated by COS. These results demonstrated that COS exerted pro-apoptotic effects on neutrophils, and superoxide played an important role in neutrophil apoptosis caused by COS. By the use of inhibitors of PLO and PI3K respectively, administration of 1-butanol and wortamannin decreased the generation of superoxide stimulated by COS. The production of superoxide caused by COS resulted from the activation of PLO and PI3K to some extent. (C) 2008 Elsevier Ltd. All rights reserved.
关键词[WOS]: PHOSPHOLIPASE-D ;  POLYMORPHONUCLEAR LEUKOCYTES ;  PHOSPHATIDIC-ACID ;  NITRIC-OXIDE ;  APOPTOSIS ;  RELEASE ;  CHITIN ;  CHITOOLIGOSACCHARIDES ;  MYELOPEROXIDASE ;  INVOLVEMENT
语种: 英语
原文出处: 查看原文
WOS记录号: WOS:000260148600019
Citation statistics: 
内容类型: 期刊论文
URI标识: http://cas-ir.dicp.ac.cn/handle/321008/101049
Appears in Collections:中国科学院大连化学物理研究所_期刊论文

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作者单位: 1.Chinese Acad Sci, Dalian Inst Chem Phys, Dalian 116023, Peoples R China
2.Chinese Acad Sci, Grad Univ, Beijing 100049, Peoples R China

Recommended Citation:
Dou, Jiangli,Xu, Qingsong,Tan, Chengyu,et al. Effects of chitosan oligosaccharides on neutrophils from glycogen-induced peritonitis mice model[J]. CARBOHYDRATE POLYMERS,2009,75(1):119-124.
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