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Effects of chitosan oligosaccharides on neutrophils from glycogen-induced peritonitis mice model
Dou, Jiangli1,2; Xu, Qingsong1,2; Tan, Chengyu1; Wang, Wenxia1,2; Du, Yuguang1; Bai, Xuefang1; Ma, Xiaojun1; Du YG(杜昱光); Du YG(杜昱光)
关键词Chitosan Oligosaccharides Neutrophil Superoxide Apoptosis Inflammation
刊名CARBOHYDRATE POLYMERS
2009-01-05
ISSNISSN: 0144-8617
DOI10.1016/j.carbpol.2008.07.005
75期:1页:119-124
收录类别SCI
文章类型Article
部门归属18
项目归属1805,1802
产权排名1;1
WOS标题词Science & Technology ; Physical Sciences
类目[WOS]Chemistry, Applied ; Chemistry, Organic ; Polymer Science
研究领域[WOS]Chemistry ; Polymer Science
关键词[WOS]PHOSPHOLIPASE-D ; POLYMORPHONUCLEAR LEUKOCYTES ; PHOSPHATIDIC-ACID ; NITRIC-OXIDE ; APOPTOSIS ; RELEASE ; CHITIN ; CHITOOLIGOSACCHARIDES ; MYELOPEROXIDASE ; INVOLVEMENT
英文摘要To investigate the effects of chitosan oligosaccharides (COS) on the neutrophils from glycogen-induced peritonitis mice model, the production of superoxide and hydrogen peroxide, myeloperoxidase (MPO) release as well as apoptosis were measured. We found that 100 mu g/ml COS supplementation could induce the production of superoxide and hydrogen peroxide by neutrophils, meanwhile, COS promoted the apoptosis of peritoneal neutrophils, whereas the MPO release was decreased. Furthermore, superoxide dismutase (SOD) administration could abolish the pro-apoptotic effects mediated by COS. These results demonstrated that COS exerted pro-apoptotic effects on neutrophils, and superoxide played an important role in neutrophil apoptosis caused by COS. By the use of inhibitors of PLO and PI3K respectively, administration of 1-butanol and wortamannin decreased the generation of superoxide stimulated by COS. The production of superoxide caused by COS resulted from the activation of PLO and PI3K to some extent. (C) 2008 Elsevier Ltd. All rights reserved.
语种英语
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WOS记录号WOS:000260148600019
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被引频次:10[WOS]   [WOS记录]     [WOS相关记录]
文献类型期刊论文
条目标识符http://cas-ir.dicp.ac.cn/handle/321008/101049
专题中国科学院大连化学物理研究所
通讯作者Du YG(杜昱光); Du YG(杜昱光)
作者单位1.Chinese Acad Sci, Dalian Inst Chem Phys, Dalian 116023, Peoples R China
2.Chinese Acad Sci, Grad Univ, Beijing 100049, Peoples R China
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Dou, Jiangli,Xu, Qingsong,Tan, Chengyu,et al. Effects of chitosan oligosaccharides on neutrophils from glycogen-induced peritonitis mice model[J]. CARBOHYDRATE POLYMERS,2009,75(1):119-124.
APA Dou, Jiangli.,Xu, Qingsong.,Tan, Chengyu.,Wang, Wenxia.,Du, Yuguang.,...&杜昱光.(2009).Effects of chitosan oligosaccharides on neutrophils from glycogen-induced peritonitis mice model.CARBOHYDRATE POLYMERS,75(1),119-124.
MLA Dou, Jiangli,et al."Effects of chitosan oligosaccharides on neutrophils from glycogen-induced peritonitis mice model".CARBOHYDRATE POLYMERS 75.1(2009):119-124.
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