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题名: Chitooligosaccharides induce apoptosis of human hepatocellular carcinoma cells via up-regulation of Bax
作者: Xu, Qingsong1, 3;  Dou, Hangli1, 3;  Wei, Peng1, 3;  Tan, Chengyu1;  Yun, Xiaojing2;  Wu, Yihong2;  Bal, Xuefang1;  Ma, Xiaojun1;  Du, Yuguang1
通讯作者: 杜昱光
关键词: chitooligosaccharides ;  hepatoma ;  apoptosis ;  Bax
刊名: CARBOHYDRATE POLYMERS
发表日期: 2008-03-07
DOI: 10.1016/j.carbpol.2007.06.022
卷: 71, 期:4, 页:509-514
收录类别: SCI
文章类型: Article
部门归属: 18
项目归属: 1805,1802
产权排名: 1;1
WOS标题词: Science & Technology ;  Physical Sciences
类目[WOS]: Chemistry, Applied ;  Chemistry, Organic ;  Polymer Science
研究领域[WOS]: Chemistry ;  Polymer Science
英文摘要: Chitooligosaccharides (COS) have been shown to regulate various cellular and biological functions. However, the effect of COS on apoptosis of hepatocellular carcinoma cells remains unclear. In this study, the activity and mechanism of COS against human hepatocellular carcinoma cells (SMMC-7721 cells) were investigated in vitro. The experiments showed that COS notably induced the apoptosis of SMMC-7721 cells and increased the cleavage of poly(ADP-ribose) polymerase. It presented a dose-dependent manner, and the apoptotic rate amounted to about 38% after treatment with 0.8 mg/ml COS for 72 h. The mRNA and protein levels of Bax were up-regulated by COS. These results demonstrated that COS induced apoptosis of SMMC-7721 cells. The possible mechanism is that COS up-regulate pro-apoptotic protein Bax, and trigger the cells a start-up of the apoptosis program. (c) 2007 Elsevier Ltd. All rights reserved.
关键词[WOS]: WATER-SOLUBLE CHITOSAN ;  MOLECULAR-WEIGHT CHITOSANS ;  N-ACETYLCHITOHEXAOSE ;  OLIGOCHITOSAN ;  EXPRESSION ;  PROTEIN ;  GROWTH ;  MICE ;  LINK
语种: 英语
原文出处: 查看原文
WOS记录号: WOS:000253115600002
Citation statistics: 
内容类型: 期刊论文
URI标识: http://cas-ir.dicp.ac.cn/handle/321008/101053
Appears in Collections:中国科学院大连化学物理研究所_期刊论文

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作者单位: 1.Chinese Acad Sci, Dalian Inst Chem Phys, Dalian 116023, Peoples R China
2.Fudan Univ, Shanghai Med Coll, Ctr Gene Res, Shanghai 200032, Peoples R China
3.Chinese Acad Sci, Grad Sch, Beijing 100049, Peoples R China

Recommended Citation:
Xu, Qingsong,Dou, Hangli,Wei, Peng,et al. Chitooligosaccharides induce apoptosis of human hepatocellular carcinoma cells via up-regulation of Bax[J]. CARBOHYDRATE POLYMERS,2008,71(4):509-514.
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