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题名: Study on the interaction of porphyrin with G-quadruplex DNAs
作者: Wei, Chunying1;  Han, Gaoyi1;  Jia, Guoqing2;  Zhou, Jun2;  Li, Can2
通讯作者: 李灿
关键词: G-quadruplexes ;  porphyrin ;  spectroscopy ;  interaction
刊名: BIOPHYSICAL CHEMISTRY
发表日期: 2008-09-01
DOI: 10.1016/j.bpc.2008.06.006
卷: 137, 期:1, 页:19-23
收录类别: SCI
文章类型: Article
部门归属: 5
项目归属: 503
产权排名: 2;3
WOS标题词: Science & Technology ;  Life Sciences & Biomedicine ;  Physical Sciences
类目[WOS]: Biochemistry & Molecular Biology ;  Biophysics ;  Chemistry, Physical
研究领域[WOS]: Biochemistry & Molecular Biology ;  Biophysics ;  Chemistry
英文摘要: Interactions of 5,10,15,20-Tetrakis(N-propylpyridinium-4-yl)-21H,23H-porphyrin (TPrPyP4) with dimer hairpin (G(4)T(4)G(4))2 and parallel four-stranded (TG(4)T)4 G-quadruplex DNAs in Na+-containing buffer were studied. The results show that two TPrPyP4 molecules bind to both G-quadruplexes by a noncooperative and nonequivalent binding mode, and there are one high affinity site and one low affinity site, the respective binding constants are 8.06 x 10(8) and 1.13 x 10(6) M-1 for (G(4)T(4)G(4))2-TPrPyP4, 8.04 x 10(7) and 9.08 X 10(5)M(-1) for (TG(4)T)4-TPrPyP4. TPrPyP4 presents two lifetimes of about 5.8 and 12.0 ns in the complexes cf G-quadruplexes-TPrPyP4. The primary results suggest that two TPrPyP4 molecules bind to both G-quadruplexes by terminal stacking and outside binding mode. (c) 2008 Elsevier B.V. All rights reserved.
关键词[WOS]: CATIONIC PORPHYRINS ;  STRUCTURAL BASIS ;  LIGAND-BINDING ;  TELOMERIC DNA ;  COMPLEXES ;  STABILIZATION ;  FLUORESCENCE ;  SELECTIVITY
语种: 英语
原文出处: 查看原文
WOS记录号: WOS:000258890800004
Citation statistics: 
内容类型: 期刊论文
URI标识: http://cas-ir.dicp.ac.cn/handle/321008/101279
Appears in Collections:中国科学院大连化学物理研究所_期刊论文

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作者单位: 1.Shanxi Univ, Inst Mol Sci, Key Lab Chem Biol & Mol Engn, Minist Educ, Taiyuan 030006, Peoples R China
2.Chinese Acad Sci, Dalian Inst Chem Phys, State Key Lab Catalysis, Dalian 116023, Peoples R China

Recommended Citation:
Wei, Chunying,Han, Gaoyi,Jia, Guoqing,et al. Study on the interaction of porphyrin with G-quadruplex DNAs[J]. BIOPHYSICAL CHEMISTRY,2008,137(1):19-23.
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