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Study on the interaction of porphyrin with G-quadruplex DNAs
Wei, Chunying1; Han, Gaoyi1; Jia, Guoqing2; Zhou, Jun2; Li, Can2; Li C(李灿)
KeywordG-quadruplexes Porphyrin Spectroscopy Interaction
Source PublicationBIOPHYSICAL CHEMISTRY
2008-09-01
DOI10.1016/j.bpc.2008.06.006
Volume137Issue:1Pages:19-23
Indexed BySCI
SubtypeArticle
Department5
Funding Project503
Contribution Rank2;3
WOS HeadingsScience & Technology ; Life Sciences & Biomedicine ; Physical Sciences
WOS SubjectBiochemistry & Molecular Biology ; Biophysics ; Chemistry, Physical
WOS Research AreaBiochemistry & Molecular Biology ; Biophysics ; Chemistry
WOS KeywordCATIONIC PORPHYRINS ; STRUCTURAL BASIS ; LIGAND-BINDING ; TELOMERIC DNA ; COMPLEXES ; STABILIZATION ; FLUORESCENCE ; SELECTIVITY
AbstractInteractions of 5,10,15,20-Tetrakis(N-propylpyridinium-4-yl)-21H,23H-porphyrin (TPrPyP4) with dimer hairpin (G(4)T(4)G(4))2 and parallel four-stranded (TG(4)T)4 G-quadruplex DNAs in Na+-containing buffer were studied. The results show that two TPrPyP4 molecules bind to both G-quadruplexes by a noncooperative and nonequivalent binding mode, and there are one high affinity site and one low affinity site, the respective binding constants are 8.06 x 10(8) and 1.13 x 10(6) M-1 for (G(4)T(4)G(4))2-TPrPyP4, 8.04 x 10(7) and 9.08 X 10(5)M(-1) for (TG(4)T)4-TPrPyP4. TPrPyP4 presents two lifetimes of about 5.8 and 12.0 ns in the complexes cf G-quadruplexes-TPrPyP4. The primary results suggest that two TPrPyP4 molecules bind to both G-quadruplexes by terminal stacking and outside binding mode. (c) 2008 Elsevier B.V. All rights reserved.
Language英语
URL查看原文
WOS IDWOS:000258890800004
Citation statistics
Cited Times:24[WOS]   [WOS Record]     [Related Records in WOS]
Document Type期刊论文
Identifierhttp://cas-ir.dicp.ac.cn/handle/321008/101279
Collection中国科学院大连化学物理研究所
Corresponding AuthorLi C(李灿)
Affiliation1.Shanxi Univ, Inst Mol Sci, Key Lab Chem Biol & Mol Engn, Minist Educ, Taiyuan 030006, Peoples R China
2.Chinese Acad Sci, Dalian Inst Chem Phys, State Key Lab Catalysis, Dalian 116023, Peoples R China
Recommended Citation
GB/T 7714
Wei, Chunying,Han, Gaoyi,Jia, Guoqing,et al. Study on the interaction of porphyrin with G-quadruplex DNAs[J]. BIOPHYSICAL CHEMISTRY,2008,137(1):19-23.
APA Wei, Chunying,Han, Gaoyi,Jia, Guoqing,Zhou, Jun,Li, Can,&李灿.(2008).Study on the interaction of porphyrin with G-quadruplex DNAs.BIOPHYSICAL CHEMISTRY,137(1),19-23.
MLA Wei, Chunying,et al."Study on the interaction of porphyrin with G-quadruplex DNAs".BIOPHYSICAL CHEMISTRY 137.1(2008):19-23.
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