中国科学院大连化学物理研究所机构知识库
Advanced  
DICP OpenIR  > 中国科学院大连化学物理研究所  > 期刊论文
题名: The structural transition and compaction of human telomeric G-quadruplex induced by excluded volume effect under cation-deficient conditions
作者: Zhou, Jun1, 2;  Wei, Chunying1;  Jia, Guoqing1, 2;  Wang, Xiuli1, 2;  Tang, Qian3;  Feng, Zhaochi1;  Li, Can1
通讯作者: 李灿
关键词: human telomeric G-quadruplex ;  molecular crowding ;  excluded volume effect ;  structural transition ;  compaction
刊名: BIOPHYSICAL CHEMISTRY
发表日期: 2008-08-01
DOI: 10.1016/j.bpc.2008.05.005
卷: 136, 期:2-3, 页:124-127
收录类别: SCI
文章类型: Article
部门归属: 5
项目归属: 503
产权排名: 1;1
WOS标题词: Science & Technology ;  Life Sciences & Biomedicine ;  Physical Sciences
类目[WOS]: Biochemistry & Molecular Biology ;  Biophysics ;  Chemistry, Physical
研究领域[WOS]: Biochemistry & Molecular Biology ;  Biophysics ;  Chemistry
英文摘要: The structure polymorphism of human telomeric G-cluadruplex (ht-quadruplex) is currently an important topic but remains controversy. Here, we present study of the ht-cluadruplex under the cation-deficient but molecular crowding conditions by circular dichroism (CD), microchip electrophoresis (MCE) and UV-melting experiments. Our results show that with concentration increasing of poly(ethylene glycol) (PEG), the structural transition of ht-quadruplex occurs accompanied by structural compaction and enhanced stabilization, which may be caused by excluded volume effect. This work also demonstrates that htquadruplex can be well assembled without cations and the structure of ht-quadruplex is actually very complex in vivo. (c) 2008 Elsevier B.V. All rights reserved.
关键词[WOS]: MOLECULAR CROWDING CONDITIONS ;  INTRAMOLECULAR G-QUADRUPLEX ;  QUARTET STRUCTURES ;  DNA ;  SEQUENCE ;  STABILITY ;  TARGETS ;  MEDIA ;  FORMS ;  ACID
语种: 英语
原文出处: 查看原文
WOS记录号: WOS:000257821400008
Citation statistics: 
内容类型: 期刊论文
URI标识: http://cas-ir.dicp.ac.cn/handle/321008/101281
Appears in Collections:中国科学院大连化学物理研究所_期刊论文

Files in This Item:

There are no files associated with this item.


作者单位: 1.Chinese Acad Sci, Dalian Inst Chem Phys, State Key Lab Catalysis, Dalian 116023, Peoples R China
2.Chinese Acad Sci, Grad Sch, Beijing 100039, Peoples R China
3.Dalian Univ Technol, Bioengn Coll, Dalian 116622, Peoples R China

Recommended Citation:
Zhou, Jun,Wei, Chunying,Jia, Guoqing,et al. The structural transition and compaction of human telomeric G-quadruplex induced by excluded volume effect under cation-deficient conditions[J]. BIOPHYSICAL CHEMISTRY,2008,136(2-3):124-127.
Service
 Recommend this item
 Sava as my favorate item
 Show this item's statistics
 Export Endnote File
Google Scholar
 Similar articles in Google Scholar
 [Zhou, Jun]'s Articles
 [Wei, Chunying]'s Articles
 [Jia, Guoqing]'s Articles
CSDL cross search
 Similar articles in CSDL Cross Search
 [Zhou, Jun]‘s Articles
 [Wei, Chunying]‘s Articles
 [Jia, Guoqing]‘s Articles
Related Copyright Policies
Null
Social Bookmarking
  Add to CiteULike  Add to Connotea  Add to Del.icio.us  Add to Digg  Add to Reddit 
所有评论 (0)
暂无评论
 
评注功能仅针对注册用户开放,请您登录
您对该条目有什么异议,请填写以下表单,管理员会尽快联系您。
内 容:
Email:  *
单位:
验证码:   刷新
您在IR的使用过程中有什么好的想法或者建议可以反馈给我们。
标 题:
 *
内 容:
Email:  *
验证码:   刷新

Items in IR are protected by copyright, with all rights reserved, unless otherwise indicated.

 

 

Valid XHTML 1.0!
Powered by CSpace