DICP OpenIR
The structural transition and compaction of human telomeric G-quadruplex induced by excluded volume effect under cation-deficient conditions
Zhou, Jun1,2; Wei, Chunying1; Jia, Guoqing1,2; Wang, Xiuli1,2; Tang, Qian3; Feng, Zhaochi1; Li, Can1; Li C(李灿)
KeywordHuman Telomeric G-quadruplex Molecular Crowding Excluded Volume Effect Structural Transition Compaction
Source PublicationBIOPHYSICAL CHEMISTRY
2008-08-01
DOI10.1016/j.bpc.2008.05.005
Volume136Issue:2-3Pages:124-127
Indexed BySCI
SubtypeArticle
Department5
Funding Project503
Contribution Rank1;1
WOS HeadingsScience & Technology ; Life Sciences & Biomedicine ; Physical Sciences
WOS SubjectBiochemistry & Molecular Biology ; Biophysics ; Chemistry, Physical
WOS Research AreaBiochemistry & Molecular Biology ; Biophysics ; Chemistry
WOS KeywordMOLECULAR CROWDING CONDITIONS ; INTRAMOLECULAR G-QUADRUPLEX ; QUARTET STRUCTURES ; DNA ; SEQUENCE ; STABILITY ; TARGETS ; MEDIA ; FORMS ; ACID
AbstractThe structure polymorphism of human telomeric G-cluadruplex (ht-quadruplex) is currently an important topic but remains controversy. Here, we present study of the ht-cluadruplex under the cation-deficient but molecular crowding conditions by circular dichroism (CD), microchip electrophoresis (MCE) and UV-melting experiments. Our results show that with concentration increasing of poly(ethylene glycol) (PEG), the structural transition of ht-quadruplex occurs accompanied by structural compaction and enhanced stabilization, which may be caused by excluded volume effect. This work also demonstrates that htquadruplex can be well assembled without cations and the structure of ht-quadruplex is actually very complex in vivo. (c) 2008 Elsevier B.V. All rights reserved.
Language英语
URL查看原文
WOS IDWOS:000257821400008
Citation statistics
Cited Times:31[WOS]   [WOS Record]     [Related Records in WOS]
Document Type期刊论文
Identifierhttp://cas-ir.dicp.ac.cn/handle/321008/101281
Collection中国科学院大连化学物理研究所
Corresponding AuthorLi C(李灿)
Affiliation1.Chinese Acad Sci, Dalian Inst Chem Phys, State Key Lab Catalysis, Dalian 116023, Peoples R China
2.Chinese Acad Sci, Grad Sch, Beijing 100039, Peoples R China
3.Dalian Univ Technol, Bioengn Coll, Dalian 116622, Peoples R China
Recommended Citation
GB/T 7714
Zhou, Jun,Wei, Chunying,Jia, Guoqing,et al. The structural transition and compaction of human telomeric G-quadruplex induced by excluded volume effect under cation-deficient conditions[J]. BIOPHYSICAL CHEMISTRY,2008,136(2-3):124-127.
APA Zhou, Jun.,Wei, Chunying.,Jia, Guoqing.,Wang, Xiuli.,Tang, Qian.,...&李灿.(2008).The structural transition and compaction of human telomeric G-quadruplex induced by excluded volume effect under cation-deficient conditions.BIOPHYSICAL CHEMISTRY,136(2-3),124-127.
MLA Zhou, Jun,et al."The structural transition and compaction of human telomeric G-quadruplex induced by excluded volume effect under cation-deficient conditions".BIOPHYSICAL CHEMISTRY 136.2-3(2008):124-127.
Files in This Item:
There are no files associated with this item.
Related Services
Recommend this item
Bookmark
Usage statistics
Export to Endnote
Google Scholar
Similar articles in Google Scholar
[Zhou, Jun]'s Articles
[Wei, Chunying]'s Articles
[Jia, Guoqing]'s Articles
Baidu academic
Similar articles in Baidu academic
[Zhou, Jun]'s Articles
[Wei, Chunying]'s Articles
[Jia, Guoqing]'s Articles
Bing Scholar
Similar articles in Bing Scholar
[Zhou, Jun]'s Articles
[Wei, Chunying]'s Articles
[Jia, Guoqing]'s Articles
Terms of Use
No data!
Social Bookmark/Share
All comments (0)
No comment.
 

Items in the repository are protected by copyright, with all rights reserved, unless otherwise indicated.