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The structural transition and compaction of human telomeric G-quadruplex induced by excluded volume effect under cation-deficient conditions
Zhou, Jun1,2; Wei, Chunying1; Jia, Guoqing1,2; Wang, Xiuli1,2; Tang, Qian3; Feng, Zhaochi1; Li, Can1; Li C(李灿)
关键词Human Telomeric G-quadruplex Molecular Crowding Excluded Volume Effect Structural Transition Compaction
刊名BIOPHYSICAL CHEMISTRY
2008-08-01
DOI10.1016/j.bpc.2008.05.005
136期:2-3页:124-127
收录类别SCI
文章类型Article
部门归属5
项目归属503
产权排名1;1
WOS标题词Science & Technology ; Life Sciences & Biomedicine ; Physical Sciences
类目[WOS]Biochemistry & Molecular Biology ; Biophysics ; Chemistry, Physical
研究领域[WOS]Biochemistry & Molecular Biology ; Biophysics ; Chemistry
关键词[WOS]MOLECULAR CROWDING CONDITIONS ; INTRAMOLECULAR G-QUADRUPLEX ; QUARTET STRUCTURES ; DNA ; SEQUENCE ; STABILITY ; TARGETS ; MEDIA ; FORMS ; ACID
英文摘要The structure polymorphism of human telomeric G-cluadruplex (ht-quadruplex) is currently an important topic but remains controversy. Here, we present study of the ht-cluadruplex under the cation-deficient but molecular crowding conditions by circular dichroism (CD), microchip electrophoresis (MCE) and UV-melting experiments. Our results show that with concentration increasing of poly(ethylene glycol) (PEG), the structural transition of ht-quadruplex occurs accompanied by structural compaction and enhanced stabilization, which may be caused by excluded volume effect. This work also demonstrates that htquadruplex can be well assembled without cations and the structure of ht-quadruplex is actually very complex in vivo. (c) 2008 Elsevier B.V. All rights reserved.
语种英语
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WOS记录号WOS:000257821400008
引用统计
被引频次:31[WOS]   [WOS记录]     [WOS相关记录]
文献类型期刊论文
条目标识符http://cas-ir.dicp.ac.cn/handle/321008/101281
专题中国科学院大连化学物理研究所
通讯作者Li C(李灿)
作者单位1.Chinese Acad Sci, Dalian Inst Chem Phys, State Key Lab Catalysis, Dalian 116023, Peoples R China
2.Chinese Acad Sci, Grad Sch, Beijing 100039, Peoples R China
3.Dalian Univ Technol, Bioengn Coll, Dalian 116622, Peoples R China
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GB/T 7714
Zhou, Jun,Wei, Chunying,Jia, Guoqing,et al. The structural transition and compaction of human telomeric G-quadruplex induced by excluded volume effect under cation-deficient conditions[J]. BIOPHYSICAL CHEMISTRY,2008,136(2-3):124-127.
APA Zhou, Jun.,Wei, Chunying.,Jia, Guoqing.,Wang, Xiuli.,Tang, Qian.,...&李灿.(2008).The structural transition and compaction of human telomeric G-quadruplex induced by excluded volume effect under cation-deficient conditions.BIOPHYSICAL CHEMISTRY,136(2-3),124-127.
MLA Zhou, Jun,et al."The structural transition and compaction of human telomeric G-quadruplex induced by excluded volume effect under cation-deficient conditions".BIOPHYSICAL CHEMISTRY 136.2-3(2008):124-127.
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