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题名: Anti-androgen-independent prostate cancer effects of ginsenoside metabolites In Vitro: Mechanism and possible structure-activity relationship investigation
作者: Li, Wei2;  Liu, Yong1;  Zhang, Jiang-Wei1;  Ai, Chun-Zhi2;  Xiang, Nan3;  Liu, Hui-Xin2;  Yang, Ling1
通讯作者: 杨凌
关键词: Ginsenosides ;  Structure-activity relationship ;  Anti-androgen-independent prostate cancer ;  In vitro ;  Intestinal bacterial metabolites
刊名: ARCHIVES OF PHARMACAL RESEARCH
发表日期: 2009
DOI: 10.1007/s12272-009-1117-1
卷: 32, 期:1, 页:49-57
收录类别: SCI
文章类型: Article
部门归属: 18
项目归属: 1806
产权排名: 1;1
WOS标题词: Science & Technology ;  Life Sciences & Biomedicine
类目[WOS]: Chemistry, Medicinal ;  Pharmacology & Pharmacy
研究领域[WOS]: Pharmacology & Pharmacy
英文摘要: Treatment of androgen-independent prostate cancer (AIPC) remains unsatisfactory. In our present experiment, natural occurring ginsenosides (NOGs) and intestinal bacterial metabolites (IBMs) were employed to investigate their anti-AIPC cell growth activity using PC-3 cells. Our results showed that the IBMs exerted more portent anti-AIPC activity than NOGs, by decreasing survival rate, inhibiting proliferation, inducing apoptosis, and leading to cell cycle arrest in AIPC PC-3 cells. The increase of LogP and decrease of C-6 steric hindrance, which were caused by deglycosylation by intestinal bacteria, may be the reason for the higher anti-AIPC activity of IBMs.
关键词[WOS]: INTESTINAL BACTERIAL METABOLITE ;  HUMAN CYTOCHROME-P450 ENZYMES ;  PLANT GLYCOSIDES ;  PANAX-GINSENG ;  CELL-LINE ;  APOPTOSIS ;  PROLIFERATION ;  MITOCHONDRIA ;  ACTIVATION ;  SAPONINS
语种: 英语
原文出处: 查看原文
WOS记录号: WOS:000262851700007
Citation statistics: 
内容类型: 期刊论文
URI标识: http://cas-ir.dicp.ac.cn/handle/321008/101529
Appears in Collections:中国科学院大连化学物理研究所_期刊论文

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作者单位: 1.Chinese Acad Sci, Dalian Inst Chem Phys, Lab Pharmaceut Resource Discovery, Dalian 116023, Peoples R China
2.Chinese Acad Sci, Grad Univ, Beijing, Peoples R China
3.Dalian Med Univ, Dalian 116027, Peoples R China

Recommended Citation:
Li, Wei,Liu, Yong,Zhang, Jiang-Wei,et al. Anti-androgen-independent prostate cancer effects of ginsenoside metabolites In Vitro: Mechanism and possible structure-activity relationship investigation[J]. ARCHIVES OF PHARMACAL RESEARCH,2009,32(1):49-57.
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