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题名: Comprehensive two-dimensional high-performance liquid chromatography system with immobilized liposome chromatography column and reversed-phase column for separation of complex traditional Chinese medicine Longdan Xiegan Decoction
作者: Wang, Yun1, 2, 3;  Kong, Liang4;  Lei, Xiaoyuan1;  Hu, Lianghai1;  Zou, Hanfa1;  Welbeck, Ed5;  Bligh, S. W. Annie5;  Wang, Zhengtao2, 3
通讯作者: 邹汉法 ;  Zhengtao Wang
关键词: Comprehensive two-dimensional chromatography ;  ILC column ;  Biological finger printing analysis ;  Longdan Xiegan Decoction ;  Traditional Chinese medicine
刊名: JOURNAL OF CHROMATOGRAPHY A
发表日期: 2009-03-13
DOI: 10.1016/j.chroma.2008.05.074
卷: 1216, 期:11, 页:2185-2191
收录类别: SCI
文章类型: Article
部门归属: 18
项目归属: 1809
产权排名: 2;1
WOS标题词: Science & Technology ;  Life Sciences & Biomedicine ;  Physical Sciences
类目[WOS]: Biochemical Research Methods ;  Chemistry, Analytical
研究领域[WOS]: Biochemistry & Molecular Biology ;  Chemistry
英文摘要: A comprehensive two-dimensional HPLC system with an immobilized liposome chromatography (ILC) column in conjunction with all RP column (in tandem) was developed for the screening and analysis of the membrane-permeable Compounds in a traditional Chinese medicine prescription Longdan Xiegan Decoction (LXD). More than 50 components in LXD were resolved using the developed separation system. Eight flavonoids and two iridoids were identified interacting with the ILC column: a system that mimics biomembranes. The results show that the developed comprehensive two-dimensional chromatography system can be used for identifying membrane permeable natural products in complex matrixes such as extracts of traditional Chinese medicine prescriptions. (C) 2008 Published by Elsevier B.V.
关键词[WOS]: TANDEM MASS-SPECTROMETRY ;  PROTEIN ;  IDENTIFICATION ;  MEMBRANE ;  HPLC ;  PRESCRIPTION ;  DIGESTION
语种: 英语
原文出处: 查看原文
WOS记录号: WOS:000264226500028
Citation statistics: 
内容类型: 期刊论文
URI标识: http://cas-ir.dicp.ac.cn/handle/321008/101569
Appears in Collections:中国科学院大连化学物理研究所_期刊论文

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作者单位: 1.Chinese Acad Sci, Dalian Inst Chem Phys, Natl Chromatog R&A Ctr, Dalian 116023, Peoples R China
2.Shanghai Univ Tradit Chinese Med, Minist Educat, Key Lab Standuidizat Chinese Med, Shanghai 201210, Peoples R China
3.China Pharmaceut Univ, Dept Pharmacognosy, Nanjing 210038, Peoples R China
4.Dalian Fisheries Univ, Coll Marine Environm Engn, Dalian 116023, Peoples R China
5.London Metropolitan Univ, Inst Hlth Res & Policy, London N7 8D8, England

Recommended Citation:
Wang, Yun,Kong, Liang,Lei, Xiaoyuan,et al. Comprehensive two-dimensional high-performance liquid chromatography system with immobilized liposome chromatography column and reversed-phase column for separation of complex traditional Chinese medicine Longdan Xiegan Decoction[J]. JOURNAL OF CHROMATOGRAPHY A,2009,1216(11):2185-2191.
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