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题名: Determination of Tangeretin in Rat Plasma by LC-Electrospray-Ion Trap MS
作者: Zhou, Da-Yong1, 2;  Chen, De-Liang3;  Yang, Xian-Dong4;  Xu, Qing1;  Xue, Xing-Ya1;  Zhang, Fei-Fang1;  Liang, Xin-Miao1
通讯作者: 梁鑫淼
关键词: Column liquid chromatography-mass spectrometry ;  Solid phase extraction ;  Tangeretin in rat plasma
刊名: CHROMATOGRAPHIA
发表日期: 2009
DOI: 10.1365/s10337-008-0812-2
卷: 69, 期:1-2, 页:27-31
收录类别: SCI
文章类型: Article
部门归属: 18
项目归属: 1803
产权排名: 2;1
WOS标题词: Science & Technology ;  Life Sciences & Biomedicine ;  Physical Sciences
类目[WOS]: Biochemical Research Methods ;  Chemistry, Analytical
研究领域[WOS]: Biochemistry & Molecular Biology ;  Chemistry
英文摘要: A selective, sensitive, and accurate method has been developed and validated for the quantification of tangeretin in rat plasma. The application of LC-electrospray-ion trap mass spectrometry in full scan and multiple reactions monitoring modes were investigated. Following solid phase extraction using a hydrophilic-lipophilic balance cartridge, the analytes were separated on a C(18) column using an isocratic mobile phase composed of acetonitrile/water (50: 50, v/v) containing 0.3% formic acid. In full scan mode, the LOQ was 2 ng mL(-1). The standard calibration curve was linear (R(2) = 0.9999) over the concentration range 2 - 200 ng mL(-1). The precision over the concentration range was within 15% (RSD) and the accuracy was ranged from 86 to 115%. In multiple reaction monitoring mode, the LOQ was 1 ng mL(-1) and the standard calibration curve was linear (R(2) = 0.9976) over the concentration range 1-100 ng mL(-1) with a precision of 12% and accuracy rangeing from 91 to 113%.
关键词[WOS]: PRESSURE CHEMICAL-IONIZATION ;  CITRUS FLAVONE TANGERETIN ;  SQUAMOUS-CELL CARCINOMA ;  LIQUID-CHROMATOGRAPHY ;  MASS-SPECTROMETRY ;  BIOTRANSFORMATION
语种: 英语
原文出处: 查看原文
WOS记录号: WOS:000262967400004
Citation statistics: 
内容类型: 期刊论文
URI标识: http://cas-ir.dicp.ac.cn/handle/321008/101595
Appears in Collections:中国科学院大连化学物理研究所_期刊论文

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作者单位: 1.Chinese Acad Sci, Dalian Inst Chem Phys, Dalian 116023, Peoples R China
2.Dalian Polytech Univ, Coll Bio & Food Technol, Dalian 116024, Peoples R China
3.Wuhan Univ, ZhongNan Hosp, Dept Internal Med, Div Cardiol, Wuhan 430071, Peoples R China
4.Dalian Med Univ, Dalian 116027, Peoples R China

Recommended Citation:
Zhou, Da-Yong,Chen, De-Liang,Yang, Xian-Dong,et al. Determination of Tangeretin in Rat Plasma by LC-Electrospray-Ion Trap MS[J]. CHROMATOGRAPHIA,2009,69(1-2):27-31.
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