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Determination of Tangeretin in Rat Plasma by LC-Electrospray-Ion Trap MS
Zhou, Da-Yong1,2; Chen, De-Liang3; Yang, Xian-Dong4; Xu, Qing1; Xue, Xing-Ya1; Zhang, Fei-Fang1; Liang, Xin-Miao1; Liang XM(梁鑫淼)
关键词Column Liquid Chromatography-mass Spectrometry Solid Phase Extraction TangeretIn In Rat Plasma
刊名CHROMATOGRAPHIA
2009
DOI10.1365/s10337-008-0812-2
69期:1-2页:27-31
收录类别SCI
文章类型Article
部门归属18
项目归属1803
产权排名2;1
WOS标题词Science & Technology ; Life Sciences & Biomedicine ; Physical Sciences
类目[WOS]Biochemical Research Methods ; Chemistry, Analytical
研究领域[WOS]Biochemistry & Molecular Biology ; Chemistry
关键词[WOS]PRESSURE CHEMICAL-IONIZATION ; CITRUS FLAVONE TANGERETIN ; SQUAMOUS-CELL CARCINOMA ; LIQUID-CHROMATOGRAPHY ; MASS-SPECTROMETRY ; BIOTRANSFORMATION
英文摘要A selective, sensitive, and accurate method has been developed and validated for the quantification of tangeretin in rat plasma. The application of LC-electrospray-ion trap mass spectrometry in full scan and multiple reactions monitoring modes were investigated. Following solid phase extraction using a hydrophilic-lipophilic balance cartridge, the analytes were separated on a C(18) column using an isocratic mobile phase composed of acetonitrile/water (50: 50, v/v) containing 0.3% formic acid. In full scan mode, the LOQ was 2 ng mL(-1). The standard calibration curve was linear (R(2) = 0.9999) over the concentration range 2 - 200 ng mL(-1). The precision over the concentration range was within 15% (RSD) and the accuracy was ranged from 86 to 115%. In multiple reaction monitoring mode, the LOQ was 1 ng mL(-1) and the standard calibration curve was linear (R(2) = 0.9976) over the concentration range 1-100 ng mL(-1) with a precision of 12% and accuracy rangeing from 91 to 113%.
语种英语
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WOS记录号WOS:000262967400004
引用统计
文献类型期刊论文
条目标识符http://cas-ir.dicp.ac.cn/handle/321008/101595
专题中国科学院大连化学物理研究所
通讯作者Liang XM(梁鑫淼)
作者单位1.Chinese Acad Sci, Dalian Inst Chem Phys, Dalian 116023, Peoples R China
2.Dalian Polytech Univ, Coll Bio & Food Technol, Dalian 116024, Peoples R China
3.Wuhan Univ, ZhongNan Hosp, Dept Internal Med, Div Cardiol, Wuhan 430071, Peoples R China
4.Dalian Med Univ, Dalian 116027, Peoples R China
推荐引用方式
GB/T 7714
Zhou, Da-Yong,Chen, De-Liang,Yang, Xian-Dong,et al. Determination of Tangeretin in Rat Plasma by LC-Electrospray-Ion Trap MS[J]. CHROMATOGRAPHIA,2009,69(1-2):27-31.
APA Zhou, Da-Yong.,Chen, De-Liang.,Yang, Xian-Dong.,Xu, Qing.,Xue, Xing-Ya.,...&梁鑫淼.(2009).Determination of Tangeretin in Rat Plasma by LC-Electrospray-Ion Trap MS.CHROMATOGRAPHIA,69(1-2),27-31.
MLA Zhou, Da-Yong,et al."Determination of Tangeretin in Rat Plasma by LC-Electrospray-Ion Trap MS".CHROMATOGRAPHIA 69.1-2(2009):27-31.
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