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题名: Hydroxylation of tanshinone IIa in human liver microsomes is specifically catalysed by cytochrome P4502A6
作者: Liu, H. -X.1, 2;  Hu, Y.1, 2;  Liu, Y.1;  He, Y. -Q.3;  Li, W.1, 2;  Yang, L.1
通讯作者: 杨凌
关键词: Tanshinone IIa ;  cytochrome P450 ;  mono-hydroxylated metabolite
刊名: XENOBIOTICA
发表日期: 2009
DOI: 10.1080/00498250902818335
卷: 39, 期:5, 页:382-390
收录类别: SCI
文章类型: Article
部门归属: 18
项目归属: 1806
产权排名: 1;1
WOS标题词: Science & Technology ;  Life Sciences & Biomedicine
类目[WOS]: Pharmacology & Pharmacy ;  Toxicology
研究领域[WOS]: Pharmacology & Pharmacy ;  Toxicology
英文摘要: Tanshinone IIa, the primary active component of a traditional Chinese medicine Salvia miltiorrhiza (Danshen), has a wide range of pharmacological activities. In the present study, the metabolism of tanshinone IIa (5 M) by cytochrome P450s (CYPs) was investigated in human liver microsomes. One mono-hydroxylated metabolite was detected in a reaction catalysed by human liver microsomes, and was identified as tanshinone IIb by comparing the tandem mass spectra and the chromatographic retention time with that of the standard compound. The study with a chemical selective inhibitor, cDNA-expressed human cytochrome P450s, correlation assay, and kinetics study demonstrated that CYP2A6 was the specific isozyme responsible for the hydroxyl metabolism of tanshinone IIa (5 M) in human liver microsomes.
关键词[WOS]: HERB SALVIA-MILTIORRHIZA ;  INDUCTION ;  EXTRACT ;  DISPOSITION ;  METABOLISM ;  NICOTINE ;  CYP2A6
语种: 英语
原文出处: 查看原文
WOS记录号: WOS:000265416400004
Citation statistics: 
内容类型: 期刊论文
URI标识: http://cas-ir.dicp.ac.cn/handle/321008/101641
Appears in Collections:中国科学院大连化学物理研究所_期刊论文

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作者单位: 1.Chinese Acad Sci, Dalian Inst Chem Phys, Lab Pharmaceut Resource Discovery, Dalian, Peoples R China
2.Chinese Acad Sci, Grad Sch, Beijing 100049, Peoples R China
3.Shanghai Univ Tradit Chinese Med, Shanghai, Peoples R China

Recommended Citation:
Liu, H. -X.,Hu, Y.,Liu, Y.,et al. Hydroxylation of tanshinone IIa in human liver microsomes is specifically catalysed by cytochrome P4502A6[J]. XENOBIOTICA,2009,39(5):382-390.
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