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Preparation of Core-shell Magnetic Molecularly Imprinted Polymer Nanoparticles for Recognition of Bovine Hemoglobin
Li, Lin1; He, Xiwen1; Chen, Langxing1; Zhang, Yukui1,2; Zhang YK(张玉奎)
关键词Adsorption Imprinting Magnetic Properties Nanoparticles Thin Films
刊名CHEMISTRY-AN ASIAN JOURNAL
2009
DOI10.1002/asia.200800300
4期:2页:286-293
收录类别SCI
文章类型Article
部门归属18
项目归属1810
产权排名2;4
WOS标题词Science & Technology ; Physical Sciences
类目[WOS]Chemistry, Multidisciplinary
研究领域[WOS]Chemistry
关键词[WOS]IRON-OXIDE NANOPARTICLES ; PROTEIN RECOGNITION ; SERUM-ALBUMIN ; THIN-FILMS ; SURFACE ; MICROSPHERES ; ADSORPTION ; BEADS
英文摘要In this work, the core-shell bovine hemoglobin (BHb) imprinted magnetic nanoparticles (MNPs) with a mean diameter of 210 nm were synthesized for the first time. In this protocol, the initial step involved co-precipitation of Fe(2+) and Fe(3+) in an ammonia solution. Silica was then coated on the Fe(3)O(4), nanoparticles using a sol-gel method to obtain silica shell magnetic nanoparticles. Subsequently, 3-amino-phenylboronic acid (APBA), which is the functional and cross-linking monomer, and poly(APBA) thin films were coated onto the silica-modified Fe(3)O(4) surface through oxidation with ammonium persulfate in an aqueous solution in the presence or absence of protein. The morphology, adsorption, and recognition properties of the magnetic molecularly imprinted nanomaterial were investigated by transmission electron microscopy (TEM), X-ray diffraction (XRD), thermogravimetric analysis (TGA), and vibrating sample magnetometer (VSM). Rebinding experiments were carried out to establish the equilibrium time and to determine the specific binding capacity and selective recognition. The protein adsorption results showed that poly(APBA) MIPs-coated magnetic nanoparticles have high adsorption capacity for template protein BHb and comparatively low non-specific adsorption. The imprinted magnetic nanoparticles could easily reach the adsorption equilibrium and magnetic separation under an external magnetic field, thus avoiding problems related to the bulk polymer. We believe that the imprinted polymercoated magnetic nanoparticles can be one of the most promising candidates for various applications, which include chemical and biochemical separation, cell sorting, recognition elements in biosensors, and drug delivery.
语种英语
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WOS记录号WOS:000263372700009
引用统计
被引频次:113[WOS]   [WOS记录]     [WOS相关记录]
文献类型期刊论文
条目标识符http://cas-ir.dicp.ac.cn/handle/321008/101673
专题中国科学院大连化学物理研究所
通讯作者Zhang YK(张玉奎)
作者单位1.Nankai Univ, Dept Chem, Tianjin 300071, Peoples R China
2.Chinese Acad Sci, Dalian Inst Chem Phys, Dalian 116011, Peoples R China
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GB/T 7714
Li, Lin,He, Xiwen,Chen, Langxing,et al. Preparation of Core-shell Magnetic Molecularly Imprinted Polymer Nanoparticles for Recognition of Bovine Hemoglobin[J]. CHEMISTRY-AN ASIAN JOURNAL,2009,4(2):286-293.
APA Li, Lin,He, Xiwen,Chen, Langxing,Zhang, Yukui,&张玉奎.(2009).Preparation of Core-shell Magnetic Molecularly Imprinted Polymer Nanoparticles for Recognition of Bovine Hemoglobin.CHEMISTRY-AN ASIAN JOURNAL,4(2),286-293.
MLA Li, Lin,et al."Preparation of Core-shell Magnetic Molecularly Imprinted Polymer Nanoparticles for Recognition of Bovine Hemoglobin".CHEMISTRY-AN ASIAN JOURNAL 4.2(2009):286-293.
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