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题名: Recent advances in mass spectrometry-based peptidome analysis
作者: Hu, Lianghai1;  Ye, Mingliang1;  Zou, Hanfa1
通讯作者: 邹汉法
关键词: biomarker ;  endogenous ;  mass spectrometry ;  multidimensional separation ;  peptide ;  peptidomics ;  proteomics ;  selective enrichment
刊名: EXPERT REVIEW OF PROTEOMICS
发表日期: 2009-08-01
DOI: 10.1586/EPR.09.55
卷: 6, 期:4, 页:433-447
收录类别: SCI
文章类型: Review
部门归属: 18
项目归属: 1809
产权排名: 1;1
WOS标题词: Science & Technology ;  Life Sciences & Biomedicine
类目[WOS]: Biochemical Research Methods
研究领域[WOS]: Biochemistry & Molecular Biology
英文摘要: The peptidome, which is the low-molecular-weight subset of the proteome, has attracted increasing attention in recent years. However, with the interference of high-abundance protein components in complex biological mixtures (e.g., serum), selective extraction of endogenous peptides is the first and most important step before analyzing the peptidome. A number of methods and technologies have now been developed for the selective enrichment, fractionation, quantitative analysis of the endogenous peptides and their application in the potential biomarker discovery. This review will cover the methods and technologies developed in recent years for the peptidome analysis on the selective extraction, multidimensional separation and quantitative analysis, as well as their application for clinical diagnosis and biomarker discovery. The future prospects of the peptidome are also discussed.
关键词[WOS]: 2-DIMENSIONAL LIQUID-CHROMATOGRAPHY ;  MESOPOROUS SILICA PARTICLES ;  CANCER BIOMARKER DISCOVERY ;  MOLECULAR-WEIGHT PROTEINS ;  MAGNETIC BEAD SEPARATION ;  SELDI-TOF MS ;  RP-RP-HPLC ;  HUMAN PLASMA ;  ENDOGENOUS PEPTIDES ;  HUMAN SERUM
语种: 英语
原文出处: 查看原文
WOS记录号: WOS:000270399200016
Citation statistics: 
内容类型: 期刊论文
URI标识: http://cas-ir.dicp.ac.cn/handle/321008/101785
Appears in Collections:中国科学院大连化学物理研究所_期刊论文

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作者单位: 1.Chinese Acad Sci, Key Lab Separat Sci Analyt Chem, Natl Chromatog R&A Ctr, Dalian Inst Chem Phys, Dalian 116023, Peoples R China

Recommended Citation:
Hu, Lianghai,Ye, Mingliang,Zou, Hanfa. Recent advances in mass spectrometry-based peptidome analysis[J]. EXPERT REVIEW OF PROTEOMICS,2009,6(4):433-447.
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