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Recent advances in mass spectrometry-based peptidome analysis
Hu, Lianghai; Ye, Mingliang; Zou, Hanfa; Zou HF(邹汉法)
关键词Biomarker Endogenous Mass Spectrometry Multidimensional Separation Peptide Peptidomics Proteomics Selective Enrichment
刊名EXPERT REVIEW OF PROTEOMICS
2009-08-01
ISSN1478-9450
DOI10.1586/EPR.09.55
6期:4页:433-447
收录类别SCI
文章类型Review
部门归属18
项目归属1809
产权排名1;1
WOS标题词Science & Technology ; Life Sciences & Biomedicine
类目[WOS]Biochemical Research Methods
研究领域[WOS]Biochemistry & Molecular Biology
关键词[WOS]2-DIMENSIONAL LIQUID-CHROMATOGRAPHY ; MESOPOROUS SILICA PARTICLES ; CANCER BIOMARKER DISCOVERY ; MOLECULAR-WEIGHT PROTEINS ; MAGNETIC BEAD SEPARATION ; SELDI-TOF MS ; RP-RP-HPLC ; HUMAN PLASMA ; ENDOGENOUS PEPTIDES ; HUMAN SERUM
英文摘要The peptidome, which is the low-molecular-weight subset of the proteome, has attracted increasing attention in recent years. However, with the interference of high-abundance protein components in complex biological mixtures (e.g., serum), selective extraction of endogenous peptides is the first and most important step before analyzing the peptidome. A number of methods and technologies have now been developed for the selective enrichment, fractionation, quantitative analysis of the endogenous peptides and their application in the potential biomarker discovery. This review will cover the methods and technologies developed in recent years for the peptidome analysis on the selective extraction, multidimensional separation and quantitative analysis, as well as their application for clinical diagnosis and biomarker discovery. The future prospects of the peptidome are also discussed.
语种英语
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WOS记录号WOS:000270399200016
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被引频次:35[WOS]   [WOS记录]     [WOS相关记录]
文献类型期刊论文
条目标识符http://cas-ir.dicp.ac.cn/handle/321008/101785
专题中国科学院大连化学物理研究所
通讯作者Zou HF(邹汉法)
作者单位Chinese Acad Sci, Key Lab Separat Sci Analyt Chem, Natl Chromatog R&A Ctr, Dalian Inst Chem Phys, Dalian 116023, Peoples R China
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Hu, Lianghai,Ye, Mingliang,Zou, Hanfa,et al. Recent advances in mass spectrometry-based peptidome analysis[J]. EXPERT REVIEW OF PROTEOMICS,2009,6(4):433-447.
APA Hu, Lianghai,Ye, Mingliang,Zou, Hanfa,&邹汉法.(2009).Recent advances in mass spectrometry-based peptidome analysis.EXPERT REVIEW OF PROTEOMICS,6(4),433-447.
MLA Hu, Lianghai,et al."Recent advances in mass spectrometry-based peptidome analysis".EXPERT REVIEW OF PROTEOMICS 6.4(2009):433-447.
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