DICP OpenIR
CYP1A2 is the major isoform responsible for paeonol O-demethylation in human liver microsomes
Liu, H. -X.1,2; Hu, Y.1; Liu, Y.1; He, Y. -Q.3; Li, W.1,2; Yang, L.1; Yang L(杨凌)
KeywordPaeonol Cytochrome P450 O-demethylated Metabolite
Source PublicationXENOBIOTICA
2009
DOI10.1080/00498250902998681
Volume39Issue:9Pages:672-679
Indexed BySCI
SubtypeArticle
Department18
Funding Project1806
Contribution Rank1;1
WOS HeadingsScience & Technology ; Life Sciences & Biomedicine
WOS SubjectPharmacology & Pharmacy ; Toxicology
WOS Research AreaPharmacology & Pharmacy ; Toxicology
WOS KeywordNF-KAPPA-B ; CYTOCHROME-P450 ; METABOLISM ; EXPRESSION ; INDUCTION ; ENZYMES ; POLYMORPHISM ; VARIABILITY ; INHIBITION ; MECHANISM
Abstract1. Paeonol, the primary active component of a traditional Chinese medicine Moutan Cortex, has a wide range of pharmacological activities. In the present study, the metabolism of paeonol by cytochrome P450s (CYPs) was investigated in human liver microsomes.
Language英语
URL查看原文
WOS IDWOS:000270090800005
Citation statistics
Cited Times:10[WOS]   [WOS Record]     [Related Records in WOS]
Document Type期刊论文
Identifierhttp://cas-ir.dicp.ac.cn/handle/321008/101787
Collection中国科学院大连化学物理研究所
Corresponding AuthorYang L(杨凌)
Affiliation1.Chinese Acad Sci, Dalian Inst Chem Phys, Lab Pharmaceut Resource Discovery, Dalian 116023, Peoples R China
2.Chinese Acad Sci, Grad Sch, Beijing, Peoples R China
3.Shanghai Univ Tradit Chinese Med, Shanghai, Peoples R China
Recommended Citation
GB/T 7714
Liu, H. -X.,Hu, Y.,Liu, Y.,et al. CYP1A2 is the major isoform responsible for paeonol O-demethylation in human liver microsomes[J]. XENOBIOTICA,2009,39(9):672-679.
APA Liu, H. -X..,Hu, Y..,Liu, Y..,He, Y. -Q..,Li, W..,...&杨凌.(2009).CYP1A2 is the major isoform responsible for paeonol O-demethylation in human liver microsomes.XENOBIOTICA,39(9),672-679.
MLA Liu, H. -X.,et al."CYP1A2 is the major isoform responsible for paeonol O-demethylation in human liver microsomes".XENOBIOTICA 39.9(2009):672-679.
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