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题名: CYP1A2 is the major isoform responsible for paeonol O-demethylation in human liver microsomes
作者: Liu, H. -X.1, 2;  Hu, Y.1;  Liu, Y.1;  He, Y. -Q.3;  Li, W.1, 2;  Yang, L.1
通讯作者: 杨凌
关键词: Paeonol ;  cytochrome P450 ;  O-demethylated metabolite
刊名: XENOBIOTICA
发表日期: 2009
DOI: 10.1080/00498250902998681
卷: 39, 期:9, 页:672-679
收录类别: SCI
文章类型: Article
部门归属: 18
项目归属: 1806
产权排名: 1;1
WOS标题词: Science & Technology ;  Life Sciences & Biomedicine
类目[WOS]: Pharmacology & Pharmacy ;  Toxicology
研究领域[WOS]: Pharmacology & Pharmacy ;  Toxicology
英文摘要: 1. Paeonol, the primary active component of a traditional Chinese medicine Moutan Cortex, has a wide range of pharmacological activities. In the present study, the metabolism of paeonol by cytochrome P450s (CYPs) was investigated in human liver microsomes.
关键词[WOS]: NF-KAPPA-B ;  CYTOCHROME-P450 ;  METABOLISM ;  EXPRESSION ;  INDUCTION ;  ENZYMES ;  POLYMORPHISM ;  VARIABILITY ;  INHIBITION ;  MECHANISM
语种: 英语
原文出处: 查看原文
WOS记录号: WOS:000270090800005
Citation statistics: 
内容类型: 期刊论文
URI标识: http://cas-ir.dicp.ac.cn/handle/321008/101787
Appears in Collections:中国科学院大连化学物理研究所_期刊论文

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作者单位: 1.Chinese Acad Sci, Dalian Inst Chem Phys, Lab Pharmaceut Resource Discovery, Dalian 116023, Peoples R China
2.Chinese Acad Sci, Grad Sch, Beijing, Peoples R China
3.Shanghai Univ Tradit Chinese Med, Shanghai, Peoples R China

Recommended Citation:
Liu, H. -X.,Hu, Y.,Liu, Y.,et al. CYP1A2 is the major isoform responsible for paeonol O-demethylation in human liver microsomes[J]. XENOBIOTICA,2009,39(9):672-679.
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