DICP OpenIR
Identification of Major Alkaloids in Rat Urine by HPLC/DAD/ESI-MS/MS Method Following Oral Administration of Cortex Phellodendri Decoction
Ma, Chun-Hui2; Li, Zhi-Xiong2; Wang, Long-Xing1; Tang, Yi-Hong2; Xiao, Hong-Bin1; Huang, Cheng-Gang2; Cheng-Gang Huang; Xiao HB(肖红斌)
刊名HELVETICA CHIMICA ACTA
2009
92期:2页:379-398
收录类别SCI
文章类型Article
部门归属18
项目归属1804
产权排名2;3
WOS标题词Science & Technology ; Physical Sciences
类目[WOS]Chemistry, Multidisciplinary
研究领域[WOS]Chemistry
关键词[WOS]TANDEM MASS-SPECTROMETRY ; HUMAN HEPATOMA-CELLS ; LC-MS/MS ; BERBERINE ; METABOLITES ; IONIZATION ; PALMATINE ; APOPTOSIS ; MS ; CONSTITUENTS
英文摘要A rapid, sensitive, and specific high-performance liquid chromatography (HPLC), diode-array detection, and mass-spectrometry techniques were developed for an identification of the constituents of Cortex Phellodendri and their metabolites in rat urine. The dose of 10 ml/kg of Cortex Phellodendri decoction was used for rats oral administration. 0-24-h Urine was purified using a C18 solid-phase extraction cartridge, and then analyzed by an on-line MS detector. A total of 13 characteristic HPLC peaks were detected in the urine samples. Nine of them, including five alkaloids and four of their metabolites, were tentatively elucidated as magnoflorine (1), the glucuronide conjugate of demethyleneberberine (2), menisperine (3), jatrorrhizine 3-O-glucuronide (4), berberubine 9-O-glucuronide (5), jatrorrhizine (6), the monomethyl and monohydroxy catabolite of berberubine (7), palmatine (8), and berberine (9). Identification and structural clucidation of the metabolites were performed by comparing their MS(n) spectra data with those reported.
语种英语
原文出处查看原文
WOS记录号WOS:000263865600017
引用统计
被引频次:20[WOS]   [WOS记录]     [WOS相关记录]
文献类型期刊论文
条目标识符http://cas-ir.dicp.ac.cn/handle/321008/101921
专题中国科学院大连化学物理研究所
通讯作者Cheng-Gang Huang; Xiao HB(肖红斌)
作者单位1.Chinese Acad Sci, Dalian Inst Chem Phys, Med Chem Lab, Dalian 116023, Peoples R China
2.Chinese Acad Sci, Shanghai Inst Biol Sci, Shanghai Inst Mat Med, Shanghai 201203, Peoples R China
推荐引用方式
GB/T 7714
Ma, Chun-Hui,Li, Zhi-Xiong,Wang, Long-Xing,et al. Identification of Major Alkaloids in Rat Urine by HPLC/DAD/ESI-MS/MS Method Following Oral Administration of Cortex Phellodendri Decoction[J]. HELVETICA CHIMICA ACTA,2009,92(2):379-398.
APA Ma, Chun-Hui.,Li, Zhi-Xiong.,Wang, Long-Xing.,Tang, Yi-Hong.,Xiao, Hong-Bin.,...&肖红斌.(2009).Identification of Major Alkaloids in Rat Urine by HPLC/DAD/ESI-MS/MS Method Following Oral Administration of Cortex Phellodendri Decoction.HELVETICA CHIMICA ACTA,92(2),379-398.
MLA Ma, Chun-Hui,et al."Identification of Major Alkaloids in Rat Urine by HPLC/DAD/ESI-MS/MS Method Following Oral Administration of Cortex Phellodendri Decoction".HELVETICA CHIMICA ACTA 92.2(2009):379-398.
条目包含的文件
条目无相关文件。
个性服务
推荐该条目
保存到收藏夹
查看访问统计
导出为Endnote文件
谷歌学术
谷歌学术中相似的文章
[Ma, Chun-Hui]的文章
[Li, Zhi-Xiong]的文章
[Wang, Long-Xing]的文章
百度学术
百度学术中相似的文章
[Ma, Chun-Hui]的文章
[Li, Zhi-Xiong]的文章
[Wang, Long-Xing]的文章
必应学术
必应学术中相似的文章
[Ma, Chun-Hui]的文章
[Li, Zhi-Xiong]的文章
[Wang, Long-Xing]的文章
相关权益政策
暂无数据
收藏/分享
所有评论 (0)
暂无评论
 

除非特别说明,本系统中所有内容都受版权保护,并保留所有权利。