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题名: Identification of Major Alkaloids in Rat Urine by HPLC/DAD/ESI-MS/MS Method Following Oral Administration of Cortex Phellodendri Decoction
作者: Ma, Chun-Hui2;  Li, Zhi-Xiong2;  Wang, Long-Xing1;  Tang, Yi-Hong2;  Xiao, Hong-Bin1;  Huang, Cheng-Gang2
通讯作者: Cheng-Gang Huang ;  肖红斌
刊名: HELVETICA CHIMICA ACTA
发表日期: 2009
卷: 92, 期:2, 页:379-398
收录类别: SCI
文章类型: Article
部门归属: 18
项目归属: 1804
产权排名: 2;3
WOS标题词: Science & Technology ;  Physical Sciences
类目[WOS]: Chemistry, Multidisciplinary
研究领域[WOS]: Chemistry
英文摘要: A rapid, sensitive, and specific high-performance liquid chromatography (HPLC), diode-array detection, and mass-spectrometry techniques were developed for an identification of the constituents of Cortex Phellodendri and their metabolites in rat urine. The dose of 10 ml/kg of Cortex Phellodendri decoction was used for rats oral administration. 0-24-h Urine was purified using a C18 solid-phase extraction cartridge, and then analyzed by an on-line MS detector. A total of 13 characteristic HPLC peaks were detected in the urine samples. Nine of them, including five alkaloids and four of their metabolites, were tentatively elucidated as magnoflorine (1), the glucuronide conjugate of demethyleneberberine (2), menisperine (3), jatrorrhizine 3-O-glucuronide (4), berberubine 9-O-glucuronide (5), jatrorrhizine (6), the monomethyl and monohydroxy catabolite of berberubine (7), palmatine (8), and berberine (9). Identification and structural clucidation of the metabolites were performed by comparing their MS(n) spectra data with those reported.
关键词[WOS]: TANDEM MASS-SPECTROMETRY ;  HUMAN HEPATOMA-CELLS ;  LC-MS/MS ;  BERBERINE ;  METABOLITES ;  IONIZATION ;  PALMATINE ;  APOPTOSIS ;  MS ;  CONSTITUENTS
语种: 英语
原文出处: 查看原文
WOS记录号: WOS:000263865600017
Citation statistics: 
内容类型: 期刊论文
URI标识: http://cas-ir.dicp.ac.cn/handle/321008/101921
Appears in Collections:中国科学院大连化学物理研究所_期刊论文

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作者单位: 1.Chinese Acad Sci, Dalian Inst Chem Phys, Med Chem Lab, Dalian 116023, Peoples R China
2.Chinese Acad Sci, Shanghai Inst Biol Sci, Shanghai Inst Mat Med, Shanghai 201203, Peoples R China

Recommended Citation:
Ma, Chun-Hui,Li, Zhi-Xiong,Wang, Long-Xing,et al. Identification of Major Alkaloids in Rat Urine by HPLC/DAD/ESI-MS/MS Method Following Oral Administration of Cortex Phellodendri Decoction[J]. HELVETICA CHIMICA ACTA,2009,92(2):379-398.
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