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Microfluidic droplet trapping array as nanoliter reactors for gas-liquid chemical reaction
Zhang, Qingquan1,2; Zeng, Shaojiang1,2; Qin, Jianhua1; Lin, Bingcheng1; Qin JH(秦建华); Lin BC(林炳承)
KeywordDroplets Gas-liquid Chemical Reaction Microfluidic Nanoliter Reactor
Source PublicationELECTROPHORESIS
2009-09-01
DOI10.1002/elps.200900331
Volume30Issue:18Pages:3181-3188
Indexed BySCI
SubtypeArticle
Department18
Funding Project1807
Contribution Rank1;1
WOS HeadingsScience & Technology ; Life Sciences & Biomedicine ; Physical Sciences
WOS SubjectBiochemical Research Methods ; Chemistry, Analytical
WOS Research AreaBiochemistry & Molecular Biology ; Chemistry
WOS KeywordSYSTEM ; DEVICE ; ENCAPSULATION ; SURFACTANTS ; TIME
AbstractThis article presents a simple method for trapping arrays of droplets relying on the designed microstructures of the microfluidic device, and this has been successfully used for parallel gas-liquid chemical reaction. In this approach, the trapping structure is composed of main channel, lateral channel and trapping region. Under a negative pressure, array droplets can be generated and trapped in the microstructure simultaneously, without the use of surfactant and the precise control of the flow velocity. By using a multi-layer microdevice containing the microstructures, single (pH gradient) and multiple gas-liquid reactions (metal ion-NH(3) complex reaction) can be performed in array droplets through the transmembrane diffusion of the gas. The droplets with quantitative concentration gradient can be formed by only replacing the specific membrane. The established method is simple, robust and easy to operate, demonstrating the potential of this device for droplet-based high-throughput screening.
Language英语
URL查看原文
WOS IDWOS:000270446200010
Citation statistics
Cited Times:20[WOS]   [WOS Record]     [Related Records in WOS]
Document Type期刊论文
Identifierhttp://cas-ir.dicp.ac.cn/handle/321008/102073
Collection中国科学院大连化学物理研究所
Corresponding AuthorQin JH(秦建华); Lin BC(林炳承)
Affiliation1.Chinese Acad Sci, Dalian Inst Chem Phys, Dalian, Peoples R China
2.Chinese Acad Sci, Grad Sch, Beijing, Peoples R China
Recommended Citation
GB/T 7714
Zhang, Qingquan,Zeng, Shaojiang,Qin, Jianhua,et al. Microfluidic droplet trapping array as nanoliter reactors for gas-liquid chemical reaction[J]. ELECTROPHORESIS,2009,30(18):3181-3188.
APA Zhang, Qingquan,Zeng, Shaojiang,Qin, Jianhua,Lin, Bingcheng,秦建华,&林炳承.(2009).Microfluidic droplet trapping array as nanoliter reactors for gas-liquid chemical reaction.ELECTROPHORESIS,30(18),3181-3188.
MLA Zhang, Qingquan,et al."Microfluidic droplet trapping array as nanoliter reactors for gas-liquid chemical reaction".ELECTROPHORESIS 30.18(2009):3181-3188.
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