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题名: Microfluidic droplet trapping array as nanoliter reactors for gas-liquid chemical reaction
作者: Zhang, Qingquan1, 2;  Zeng, Shaojiang1, 2;  Qin, Jianhua1;  Lin, Bingcheng1
通讯作者: 秦建华 ;  林炳承
关键词: Droplets ;  Gas-liquid chemical reaction ;  Microfluidic ;  Nanoliter reactor
刊名: ELECTROPHORESIS
发表日期: 2009-09-01
DOI: 10.1002/elps.200900331
卷: 30, 期:18, 页:3181-3188
收录类别: SCI
文章类型: Article
部门归属: 18
项目归属: 1807
产权排名: 1;1
WOS标题词: Science & Technology ;  Life Sciences & Biomedicine ;  Physical Sciences
类目[WOS]: Biochemical Research Methods ;  Chemistry, Analytical
研究领域[WOS]: Biochemistry & Molecular Biology ;  Chemistry
英文摘要: This article presents a simple method for trapping arrays of droplets relying on the designed microstructures of the microfluidic device, and this has been successfully used for parallel gas-liquid chemical reaction. In this approach, the trapping structure is composed of main channel, lateral channel and trapping region. Under a negative pressure, array droplets can be generated and trapped in the microstructure simultaneously, without the use of surfactant and the precise control of the flow velocity. By using a multi-layer microdevice containing the microstructures, single (pH gradient) and multiple gas-liquid reactions (metal ion-NH(3) complex reaction) can be performed in array droplets through the transmembrane diffusion of the gas. The droplets with quantitative concentration gradient can be formed by only replacing the specific membrane. The established method is simple, robust and easy to operate, demonstrating the potential of this device for droplet-based high-throughput screening.
关键词[WOS]: SYSTEM ;  DEVICE ;  ENCAPSULATION ;  SURFACTANTS ;  TIME
语种: 英语
原文出处: 查看原文
WOS记录号: WOS:000270446200010
Citation statistics: 
内容类型: 期刊论文
URI标识: http://cas-ir.dicp.ac.cn/handle/321008/102073
Appears in Collections:中国科学院大连化学物理研究所_期刊论文

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作者单位: 1.Chinese Acad Sci, Dalian Inst Chem Phys, Dalian, Peoples R China
2.Chinese Acad Sci, Grad Sch, Beijing, Peoples R China

Recommended Citation:
Zhang, Qingquan,Zeng, Shaojiang,Qin, Jianhua,et al. Microfluidic droplet trapping array as nanoliter reactors for gas-liquid chemical reaction[J]. ELECTROPHORESIS,2009,30(18):3181-3188.
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