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题名: The Application of Chromatography-Mass Spectrometry: Methods to Metabonomics
作者: Wu, Zeming1;  Huang, Zhiqiang2;  Lehmann, Rainer3;  Zhao, Chunxia1;  Xu, Guowang1
通讯作者: 许国旺
关键词: Column liquid chromatography ;  Gas chromatography ;  Mass spectrometry ;  Metabonomics ;  Metabolomics ;  Metabolic profiling analysis
刊名: CHROMATOGRAPHIA
发表日期: 2009
DOI: 10.1365/s10337-009-0956-8
卷: 69, 页:S23-S32
收录类别: SCI
文章类型: Review
部门归属: 18
项目归属: 1808
产权排名: 1;1
WOS标题词: Science & Technology ;  Life Sciences & Biomedicine ;  Physical Sciences
类目[WOS]: Biochemical Research Methods ;  Chemistry, Analytical
研究领域[WOS]: Biochemistry & Molecular Biology ;  Chemistry
英文摘要: The widespread availability, suitability, and high sensitivity of chromatogrophy-mass spectrometry for chemical profiling analysis of multi-component biosamples are demonstrated by the comprehensive analysis of metabolites in all kind of biofluids or tissue and cell extracts. This review provides an overview of current chromatographic-mass spectrometric metabonomic methods and applications. The focus is on the description of global metabolic profiling techniques as well as on additional important aspects of metabonomics research such as sample pretreatment and information mining methods including strategies for the identification of potential biomarkers.
关键词[WOS]: PERFORMANCE LIQUID-CHROMATOGRAPHY ;  2-DIMENSIONAL GAS-CHROMATOGRAPHY ;  HYDROPHILIC INTERACTION CHROMATOGRAPHY ;  MULTIVARIATE STATISTICAL-ANALYSIS ;  ZUCKER RAT URINE ;  LC-MS ;  CAPILLARY-ELECTROPHORESIS ;  TOF-MS ;  GC-MS ;  ESCHERICHIA-COLI
语种: 英语
原文出处: 查看原文
WOS记录号: WOS:000266557100005
Citation statistics: 
内容类型: 期刊论文
URI标识: http://cas-ir.dicp.ac.cn/handle/321008/102155
Appears in Collections:中国科学院大连化学物理研究所_期刊论文

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作者单位: 1.Chinese Acad Sci, Dalian Inst Chem Phys, Key Lab Separat Sci Analyt Chem, Dalian 116023, Peoples R China
2.Hunan Entry Exit Inspect Quarantine Bur Peoples R, Ctr Technol, Changsha 410004, Hunan, Peoples R China
3.Univ Tubingen Hosp, Cent Lab, Div Clin Chem & Pathobiochem, D-72076 Tubingen, Germany

Recommended Citation:
Wu, Zeming,Huang, Zhiqiang,Lehmann, Rainer,et al. The Application of Chromatography-Mass Spectrometry: Methods to Metabonomics[J]. CHROMATOGRAPHIA,2009,69:S23-S32.
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