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题名: Secondary Metabolic Profiling and Artemisinin Biosynthesis of Two Genotypes of Artemisia annua
作者: Wang, Huahong1;  Ma, Chenfei2;  Ma, Lanqing1;  Du, Zhigao1;  Wang, Hong1;  Ye, Hechun1;  Li, Guofeng1;  Liu, Benye1;  Xu, Guowang2
通讯作者: 许国旺
关键词: Artemisia annua L. ;  Compositae ;  atemisinin ;  genotype ;  GC-MS ;  metabolic profile ;  terpenoids
刊名: PLANTA MEDICA
发表日期: 2009-12-01
DOI: 10.1055/s-0029-1185814
卷: 75, 期:15, 页:1625-1633
收录类别: SCI
文章类型: Article
部门归属: 18
项目归属: 1808
产权排名: 2;1
WOS标题词: Science & Technology ;  Life Sciences & Biomedicine
类目[WOS]: Plant Sciences ;  Chemistry, Medicinal ;  Pharmacology & Pharmacy
研究领域[WOS]: Plant Sciences ;  Pharmacology & Pharmacy
英文摘要: Artemisinin has been proven to be an effective antimalarial compound, especially for chloroquine-resistant and cerebral malaria. However, its biosynthesis pathway is still not completely clear. In order to get new clues about artemisinin biosynthesis, metabolic profiling by gas chromatography (GC) and gas chromatography-mass spectrometry (GC-MS) was applied to compare the secondary metabolites of two Artemisia annua L., genotype SP18 and 001, for some phenotypic and agricultural trait differences, including artemisinin content, existed between the two genotypes. Samples at 7 time points of three growth stages were studied. The data of profiles were subjected to multivariate analysis with partial least squares discriminant analysis (PLS-DA). The results indicated that there were clear differences in terpenoids and artemisinin metabolism between different growth stages and genotypes. Twenty-one compounds, including artemisinin and its related precursors, were selected as the market compounds of the PLS-DA between the two genotypes. Among them, artemisinic acid, arteannuin 13, borneol, beta-farnesene and an unidentified sesquiterpenoid (peak 48) were abundant in 001, while camphor, methyl artemisinic acid and lanceol accumulated mainly in SP18. The relationship between these differences and artemisinin biosynthesis in the two genotypes of A. annua were discussed.
关键词[WOS]: FARNESYL DIPHOSPHATE SYNTHASE ;  MASS-SPECTROMETRY ;  GAS-CHROMATOGRAPHY ;  ANTIMALARIAL-DRUG ;  VOLATILE OIL ;  ARTEANNUIN-B ;  ACID ;  L. ;  PLANTS ;  METABONOMICS
语种: 英语
原文出处: 查看原文
WOS记录号: WOS:000273178400013
Citation statistics: 
内容类型: 期刊论文
URI标识: http://cas-ir.dicp.ac.cn/handle/321008/102159
Appears in Collections:中国科学院大连化学物理研究所_期刊论文

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作者单位: 1.Chinese Acad Sci, Key Lab Photosynth & Environm Mol Physiol, Inst Bot, Beijing 100093, Peoples R China
2.Chinese Acad Sci, Natl Chromatog R&A Ctr, Dalian Inst Chem Phys, Dalian, Peoples R China

Recommended Citation:
Wang, Huahong,Ma, Chenfei,Ma, Lanqing,et al. Secondary Metabolic Profiling and Artemisinin Biosynthesis of Two Genotypes of Artemisia annua[J]. PLANTA MEDICA,2009,75(15):1625-1633.
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