中国科学院大连化学物理研究所机构知识库
Advanced  
DICP OpenIR  > 中国科学院大连化学物理研究所  > 期刊论文
题名: A metabonomic study of hepatitis B-induced liver cirrhosis and hepatocellular carcinoma by using RP-LC and HILIC coupled with mass spectrometry
作者: Yin, Peiyuan1;  Wan, Dafang2;  Zhao, Chunxia1;  Chen, Jing1;  Zhao, Xinjie1;  Wang, Wenzhao1;  Lu, Xin1;  Yang, Shengli1, 2, 3;  Gu, Jianren2;  Xu, Guowang1
通讯作者: 许国旺
刊名: MOLECULAR BIOSYSTEMS
发表日期: 2009
DOI: 10.1039/b820224a
卷: 5, 期:8, 页:868-876
收录类别: SCI
文章类型: Article
部门归属: 18
项目归属: 1808
产权排名: 1;1
WOS标题词: Science & Technology ;  Life Sciences & Biomedicine
类目[WOS]: Biochemistry & Molecular Biology
研究领域[WOS]: Biochemistry & Molecular Biology
英文摘要: Liver cirrhosis and hepatocellular carcinoma (HCC) are fatal sequelaes of chronic hepatitis B in China. The sera from HCC and cirrhosis were profiled by rapid resolution liquid chromatography coupled with quadrupole time-of-flight (Q-TOF) mass spectrometry. Reversed-phased (RP) liquid chromatography and hydrophilic interaction chromatography (HILIC) were used for the data acquisition. The normalized and combined data were handled by chemometric analysis, and the combination proved to be effective and reliable for the orthogonal projection to latent structures (OPLS) analysis. Metabonomic profiles and the potential biomarkers were found based on the OPLS models. Shared and unique structure (SUS) plots were used for the evaluation of the potential biomarkers. Glycocholic acid, glycochenodeoxycholic acid, taurocholic acid and taurochenodesoxycholic acid were found to be potential biomarkers related to liver cirrhosis, while dihydrosphingosine and phytosphingosine were potential diagnostic biomarkers of HCC. The other identified metabolites were considered as common potential biomarkers for the two liver diseases. Correlation networks based on these metabolites were also built for the systemic understanding of these diseases and the possible biological implications are discussed. This metabonomic approach may provide insight into discovery and identification of new diagnostic biomarkers for liver cancer and associated diseases.
关键词[WOS]: PERFORMANCE LIQUID-CHROMATOGRAPHY ;  HYDROPHILIC INTERACTION CHROMATOGRAPHY ;  MULTIVARIATE STATISTICAL-ANALYSIS ;  INSULIN-RESISTANT MICE ;  FARNESOID-X-RECEPTOR ;  SYSTEMS BIOLOGY ;  H-1-NMR SPECTROSCOPY ;  ACID-METABOLISM ;  RAT URINE ;  BILE-ACID
语种: 英语
原文出处: 查看原文
WOS记录号: WOS:000268033800013
Citation statistics: 
内容类型: 期刊论文
URI标识: http://cas-ir.dicp.ac.cn/handle/321008/102163
Appears in Collections:中国科学院大连化学物理研究所_期刊论文

Files in This Item:

There are no files associated with this item.


作者单位: 1.Chinese Acad Sci, Dalian Inst Chem Phys, CAS Key Lab Separat Sci Analyt Chem, Dalian 116023, Peoples R China
2.Shanghai Jiao Tong Univ, Sch Med, Shanghai Canc Inst, Natl Lab Oncogenes & Related Genes, Shanghai 200032, Peoples R China
3.Chinese Acad Sci, Shanghai Res Ctr Biotechnol, Shanghai 200032, Peoples R China

Recommended Citation:
Yin, Peiyuan,Wan, Dafang,Zhao, Chunxia,et al. A metabonomic study of hepatitis B-induced liver cirrhosis and hepatocellular carcinoma by using RP-LC and HILIC coupled with mass spectrometry[J]. MOLECULAR BIOSYSTEMS,2009,5(8):868-876.
Service
 Recommend this item
 Sava as my favorate item
 Show this item's statistics
 Export Endnote File
Google Scholar
 Similar articles in Google Scholar
 [Yin, Peiyuan]'s Articles
 [Wan, Dafang]'s Articles
 [Zhao, Chunxia]'s Articles
CSDL cross search
 Similar articles in CSDL Cross Search
 [Yin, Peiyuan]‘s Articles
 [Wan, Dafang]‘s Articles
 [Zhao, Chunxia]‘s Articles
Related Copyright Policies
Null
Social Bookmarking
  Add to CiteULike  Add to Connotea  Add to Del.icio.us  Add to Digg  Add to Reddit 
所有评论 (0)
暂无评论
 
评注功能仅针对注册用户开放,请您登录
您对该条目有什么异议,请填写以下表单,管理员会尽快联系您。
内 容:
Email:  *
单位:
验证码:   刷新
您在IR的使用过程中有什么好的想法或者建议可以反馈给我们。
标 题:
 *
内 容:
Email:  *
验证码:   刷新

Items in IR are protected by copyright, with all rights reserved, unless otherwise indicated.

 

 

Valid XHTML 1.0!
Powered by CSpace