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A metabonomic study of hepatitis B-induced liver cirrhosis and hepatocellular carcinoma by using RP-LC and HILIC coupled with mass spectrometry
Yin, Peiyuan1; Wan, Dafang2; Zhao, Chunxia1; Chen, Jing1; Zhao, Xinjie1; Wang, Wenzhao1; Lu, Xin1; Yang, Shengli1,2,3; Gu, Jianren2; Xu, Guowang1; Xu GW(许国旺)
刊名MOLECULAR BIOSYSTEMS
2009
DOI10.1039/b820224a
5期:8页:868-876
收录类别SCI
文章类型Article
部门归属18
项目归属1808
产权排名1;1
WOS标题词Science & Technology ; Life Sciences & Biomedicine
类目[WOS]Biochemistry & Molecular Biology
研究领域[WOS]Biochemistry & Molecular Biology
关键词[WOS]PERFORMANCE LIQUID-CHROMATOGRAPHY ; HYDROPHILIC INTERACTION CHROMATOGRAPHY ; MULTIVARIATE STATISTICAL-ANALYSIS ; INSULIN-RESISTANT MICE ; FARNESOID-X-RECEPTOR ; SYSTEMS BIOLOGY ; H-1-NMR SPECTROSCOPY ; ACID-METABOLISM ; RAT URINE ; BILE-ACID
英文摘要Liver cirrhosis and hepatocellular carcinoma (HCC) are fatal sequelaes of chronic hepatitis B in China. The sera from HCC and cirrhosis were profiled by rapid resolution liquid chromatography coupled with quadrupole time-of-flight (Q-TOF) mass spectrometry. Reversed-phased (RP) liquid chromatography and hydrophilic interaction chromatography (HILIC) were used for the data acquisition. The normalized and combined data were handled by chemometric analysis, and the combination proved to be effective and reliable for the orthogonal projection to latent structures (OPLS) analysis. Metabonomic profiles and the potential biomarkers were found based on the OPLS models. Shared and unique structure (SUS) plots were used for the evaluation of the potential biomarkers. Glycocholic acid, glycochenodeoxycholic acid, taurocholic acid and taurochenodesoxycholic acid were found to be potential biomarkers related to liver cirrhosis, while dihydrosphingosine and phytosphingosine were potential diagnostic biomarkers of HCC. The other identified metabolites were considered as common potential biomarkers for the two liver diseases. Correlation networks based on these metabolites were also built for the systemic understanding of these diseases and the possible biological implications are discussed. This metabonomic approach may provide insight into discovery and identification of new diagnostic biomarkers for liver cancer and associated diseases.
语种英语
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WOS记录号WOS:000268033800013
引用统计
文献类型期刊论文
条目标识符http://cas-ir.dicp.ac.cn/handle/321008/102163
专题中国科学院大连化学物理研究所
通讯作者Xu GW(许国旺)
作者单位1.Chinese Acad Sci, Dalian Inst Chem Phys, CAS Key Lab Separat Sci Analyt Chem, Dalian 116023, Peoples R China
2.Shanghai Jiao Tong Univ, Sch Med, Shanghai Canc Inst, Natl Lab Oncogenes & Related Genes, Shanghai 200032, Peoples R China
3.Chinese Acad Sci, Shanghai Res Ctr Biotechnol, Shanghai 200032, Peoples R China
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Yin, Peiyuan,Wan, Dafang,Zhao, Chunxia,et al. A metabonomic study of hepatitis B-induced liver cirrhosis and hepatocellular carcinoma by using RP-LC and HILIC coupled with mass spectrometry[J]. MOLECULAR BIOSYSTEMS,2009,5(8):868-876.
APA Yin, Peiyuan.,Wan, Dafang.,Zhao, Chunxia.,Chen, Jing.,Zhao, Xinjie.,...&许国旺.(2009).A metabonomic study of hepatitis B-induced liver cirrhosis and hepatocellular carcinoma by using RP-LC and HILIC coupled with mass spectrometry.MOLECULAR BIOSYSTEMS,5(8),868-876.
MLA Yin, Peiyuan,et al."A metabonomic study of hepatitis B-induced liver cirrhosis and hepatocellular carcinoma by using RP-LC and HILIC coupled with mass spectrometry".MOLECULAR BIOSYSTEMS 5.8(2009):868-876.
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