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Analytical strategies in lipidomics and applications in disease biomarker discovery
Hu, Chunxiu1,2; van der Heijden, Rob2; Wang, Mei3; van der Greef, Jan2,3; Hankemeier, Thomas2; Xua, Guowang1; Xu GW(许国旺)
KeywordLipidomics Lipid-associated Disorders Biomarkers Lipid Profiling
Source PublicationJOURNAL OF CHROMATOGRAPHY B-ANALYTICAL TECHNOLOGIES IN THE BIOMEDICAL AND LIFE SCIENCES
2009-09-15
DOI10.1016/j.jchromb.2009.01.038
Volume877Issue:26Pages:2836-2846
Indexed BySCI
SubtypeReview
Department18
Funding Project1808
Contribution Rank1;1
WOS HeadingsScience & Technology ; Life Sciences & Biomedicine ; Physical Sciences
WOS SubjectBiochemical Research Methods ; Chemistry, Analytical
WOS Research AreaBiochemistry & Molecular Biology ; Chemistry
WOS KeywordPERFORMANCE LIQUID-CHROMATOGRAPHY ; IONIZATION MASS-SPECTROMETRY ; ASSISTED LASER-DESORPTION ; MULTIVARIATE STATISTICAL-ANALYSIS ; MALDI-TOF MS ; SHOTGUN LIPIDOMICS ; CELLULAR LIPIDOMES ; BIOLOGICAL SAMPLES ; LIPOPROTEIN METABOLISM ; PHOSPHOLIPID PROFILES
AbstractLipidomics is a lipid-targeted metabolomics approach aiming at comprehensive analysis of lipids in biological systems. Recently, lipid profiling, or so-called lipidomics research, has captured increased attention due to the well-recognized roles of lipids in numerous human diseases to which lipid-associated disorders contribute, such as diabetes, obesity, atherosclerosis and Alzheimer's disease. Investigating lipid biochemistry using a lipidomics approach will not only provide insights into the specific roles of lipid molecular species in health and disease, but will also assist in identifying potential biomarkers for establishing preventive or therapeutic approaches for human health. Recent technological advancements in mass spectrometry and rapid improvements in chromatographic techniques have led to the rapid expansion of the lipidomics research held. In this review, emphasis is given to the recent advances in lipidomics technologies and their applications in disease biomarker discovery. (C) 2009 Elsevier B.V. All rights reserved.
Language英语
URL查看原文
WOS IDWOS:000269224200017
Citation statistics
Cited Times:124[WOS]   [WOS Record]     [Related Records in WOS]
Document Type期刊论文
Identifierhttp://cas-ir.dicp.ac.cn/handle/321008/102165
Collection中国科学院大连化学物理研究所
Corresponding AuthorXu GW(许国旺)
Affiliation1.Chinese Acad Sci, Dalian Inst Chem Phys, Key Lab Separat Sci Analyt Chem, Dalian 116023, Peoples R China
2.Leiden Univ, Div Analyt Biosci, LACDR, NL-2300 RA Leiden, Netherlands
3.SU BioMed & TNO Qual Life, NL-3700 AJ Zeist, Netherlands
Recommended Citation
GB/T 7714
Hu, Chunxiu,van der Heijden, Rob,Wang, Mei,et al. Analytical strategies in lipidomics and applications in disease biomarker discovery[J]. JOURNAL OF CHROMATOGRAPHY B-ANALYTICAL TECHNOLOGIES IN THE BIOMEDICAL AND LIFE SCIENCES,2009,877(26):2836-2846.
APA Hu, Chunxiu.,van der Heijden, Rob.,Wang, Mei.,van der Greef, Jan.,Hankemeier, Thomas.,...&许国旺.(2009).Analytical strategies in lipidomics and applications in disease biomarker discovery.JOURNAL OF CHROMATOGRAPHY B-ANALYTICAL TECHNOLOGIES IN THE BIOMEDICAL AND LIFE SCIENCES,877(26),2836-2846.
MLA Hu, Chunxiu,et al."Analytical strategies in lipidomics and applications in disease biomarker discovery".JOURNAL OF CHROMATOGRAPHY B-ANALYTICAL TECHNOLOGIES IN THE BIOMEDICAL AND LIFE SCIENCES 877.26(2009):2836-2846.
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