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Analytical strategies in lipidomics and applications in disease biomarker discovery
Hu, Chunxiu1,2; van der Heijden, Rob2; Wang, Mei3; van der Greef, Jan2,3; Hankemeier, Thomas2; Xua, Guowang1; Xu GW(许国旺)
关键词Lipidomics Lipid-associated Disorders Biomarkers Lipid Profiling
刊名JOURNAL OF CHROMATOGRAPHY B-ANALYTICAL TECHNOLOGIES IN THE BIOMEDICAL AND LIFE SCIENCES
2009-09-15
DOI10.1016/j.jchromb.2009.01.038
877期:26页:2836-2846
收录类别SCI
文章类型Review
部门归属18
项目归属1808
产权排名1;1
WOS标题词Science & Technology ; Life Sciences & Biomedicine ; Physical Sciences
类目[WOS]Biochemical Research Methods ; Chemistry, Analytical
研究领域[WOS]Biochemistry & Molecular Biology ; Chemistry
关键词[WOS]PERFORMANCE LIQUID-CHROMATOGRAPHY ; IONIZATION MASS-SPECTROMETRY ; ASSISTED LASER-DESORPTION ; MULTIVARIATE STATISTICAL-ANALYSIS ; MALDI-TOF MS ; SHOTGUN LIPIDOMICS ; CELLULAR LIPIDOMES ; BIOLOGICAL SAMPLES ; LIPOPROTEIN METABOLISM ; PHOSPHOLIPID PROFILES
英文摘要Lipidomics is a lipid-targeted metabolomics approach aiming at comprehensive analysis of lipids in biological systems. Recently, lipid profiling, or so-called lipidomics research, has captured increased attention due to the well-recognized roles of lipids in numerous human diseases to which lipid-associated disorders contribute, such as diabetes, obesity, atherosclerosis and Alzheimer's disease. Investigating lipid biochemistry using a lipidomics approach will not only provide insights into the specific roles of lipid molecular species in health and disease, but will also assist in identifying potential biomarkers for establishing preventive or therapeutic approaches for human health. Recent technological advancements in mass spectrometry and rapid improvements in chromatographic techniques have led to the rapid expansion of the lipidomics research held. In this review, emphasis is given to the recent advances in lipidomics technologies and their applications in disease biomarker discovery. (C) 2009 Elsevier B.V. All rights reserved.
语种英语
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WOS记录号WOS:000269224200017
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文献类型期刊论文
条目标识符http://cas-ir.dicp.ac.cn/handle/321008/102165
专题中国科学院大连化学物理研究所
通讯作者Xu GW(许国旺)
作者单位1.Chinese Acad Sci, Dalian Inst Chem Phys, Key Lab Separat Sci Analyt Chem, Dalian 116023, Peoples R China
2.Leiden Univ, Div Analyt Biosci, LACDR, NL-2300 RA Leiden, Netherlands
3.SU BioMed & TNO Qual Life, NL-3700 AJ Zeist, Netherlands
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Hu, Chunxiu,van der Heijden, Rob,Wang, Mei,et al. Analytical strategies in lipidomics and applications in disease biomarker discovery[J]. JOURNAL OF CHROMATOGRAPHY B-ANALYTICAL TECHNOLOGIES IN THE BIOMEDICAL AND LIFE SCIENCES,2009,877(26):2836-2846.
APA Hu, Chunxiu.,van der Heijden, Rob.,Wang, Mei.,van der Greef, Jan.,Hankemeier, Thomas.,...&许国旺.(2009).Analytical strategies in lipidomics and applications in disease biomarker discovery.JOURNAL OF CHROMATOGRAPHY B-ANALYTICAL TECHNOLOGIES IN THE BIOMEDICAL AND LIFE SCIENCES,877(26),2836-2846.
MLA Hu, Chunxiu,et al."Analytical strategies in lipidomics and applications in disease biomarker discovery".JOURNAL OF CHROMATOGRAPHY B-ANALYTICAL TECHNOLOGIES IN THE BIOMEDICAL AND LIFE SCIENCES 877.26(2009):2836-2846.
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