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题名: Analytical strategies in lipidomics and applications in disease biomarker discovery
作者: Hu, Chunxiu1, 2;  van der Heijden, Rob2;  Wang, Mei3;  van der Greef, Jan2, 3;  Hankemeier, Thomas2;  Xua, Guowang1
通讯作者: 许国旺
关键词: Lipidomics ;  Lipid-associated disorders ;  Biomarkers ;  Lipid profiling
刊名: JOURNAL OF CHROMATOGRAPHY B-ANALYTICAL TECHNOLOGIES IN THE BIOMEDICAL AND LIFE SCIENCES
发表日期: 2009-09-15
DOI: 10.1016/j.jchromb.2009.01.038
卷: 877, 期:26, 页:2836-2846
收录类别: SCI
文章类型: Review
部门归属: 18
项目归属: 1808
产权排名: 1;1
WOS标题词: Science & Technology ;  Life Sciences & Biomedicine ;  Physical Sciences
类目[WOS]: Biochemical Research Methods ;  Chemistry, Analytical
研究领域[WOS]: Biochemistry & Molecular Biology ;  Chemistry
英文摘要: Lipidomics is a lipid-targeted metabolomics approach aiming at comprehensive analysis of lipids in biological systems. Recently, lipid profiling, or so-called lipidomics research, has captured increased attention due to the well-recognized roles of lipids in numerous human diseases to which lipid-associated disorders contribute, such as diabetes, obesity, atherosclerosis and Alzheimer's disease. Investigating lipid biochemistry using a lipidomics approach will not only provide insights into the specific roles of lipid molecular species in health and disease, but will also assist in identifying potential biomarkers for establishing preventive or therapeutic approaches for human health. Recent technological advancements in mass spectrometry and rapid improvements in chromatographic techniques have led to the rapid expansion of the lipidomics research held. In this review, emphasis is given to the recent advances in lipidomics technologies and their applications in disease biomarker discovery. (C) 2009 Elsevier B.V. All rights reserved.
关键词[WOS]: PERFORMANCE LIQUID-CHROMATOGRAPHY ;  IONIZATION MASS-SPECTROMETRY ;  ASSISTED LASER-DESORPTION ;  MULTIVARIATE STATISTICAL-ANALYSIS ;  MALDI-TOF MS ;  SHOTGUN LIPIDOMICS ;  CELLULAR LIPIDOMES ;  BIOLOGICAL SAMPLES ;  LIPOPROTEIN METABOLISM ;  PHOSPHOLIPID PROFILES
语种: 英语
原文出处: 查看原文
WOS记录号: WOS:000269224200017
Citation statistics: 
内容类型: 期刊论文
URI标识: http://cas-ir.dicp.ac.cn/handle/321008/102165
Appears in Collections:中国科学院大连化学物理研究所_期刊论文

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作者单位: 1.Chinese Acad Sci, Dalian Inst Chem Phys, Key Lab Separat Sci Analyt Chem, Dalian 116023, Peoples R China
2.Leiden Univ, Div Analyt Biosci, LACDR, NL-2300 RA Leiden, Netherlands
3.SU BioMed & TNO Qual Life, NL-3700 AJ Zeist, Netherlands

Recommended Citation:
Hu, Chunxiu,van der Heijden, Rob,Wang, Mei,et al. Analytical strategies in lipidomics and applications in disease biomarker discovery[J]. JOURNAL OF CHROMATOGRAPHY B-ANALYTICAL TECHNOLOGIES IN THE BIOMEDICAL AND LIFE SCIENCES,2009,877(26):2836-2846.
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