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题名: In vivo Inhibition of S180 Tumors by the Synergistic Effect of the Chinese Medicinal Herbs Coptis chinensis and Evodia rutaecarpa
作者: Wang, Xiao-na2;  Xu, Li-na2;  Peng, Jin-yong1, 2;  Liu, Ke-xin2;  Zhang, Li-hua1;  Zhang, Yu-kui1
通讯作者: 彭金咏 ;  张丽华
关键词: Coptis chinensis Franch ;  Evodia rutaecarpa (Juss.) Benth ;  Zuojinwan ;  synergy ;  Ranunculaceae ;  Rutaceae
刊名: PLANTA MEDICA
发表日期: 2009-09-01
DOI: 10.1055/s-0029-1185538
卷: 75, 期:11, 页:1215-1220
收录类别: SCI
文章类型: Article
部门归属: 18
项目归属: 1810
产权排名: 2;3
WOS标题词: Science & Technology ;  Life Sciences & Biomedicine
类目[WOS]: Plant Sciences ;  Chemistry, Medicinal ;  Pharmacology & Pharmacy
研究领域[WOS]: Plant Sciences ;  Pharmacology & Pharmacy
英文摘要: The aim of the present paper was to investigate the synergistic effect and mechanism of anticancer activity of Zuojinwan (ZJW) comprising Coptis chinensis Franch (HL) and Evodia rutaecarpa (Juss.) Benth (WZY) at a ratio of 6: 1 (w/w). In vivo anticancer activity testing was carried out by inhibiting the growth of S180 tumor. Tumor growth inhibition, spleen index, lymphocyte proliferation, apoptosis, tumor necrosis factor-alpha (TNF-alpha) level, activities of serum tumor markers (TMs), increase in life span (ILS), histopathology and gene expression were tested. The results indicated that ZJW could significantly induce apoptosis of cancer cells. The inhibition ratio, ILS and TNF-alpha levels of mice treated with ZJW were 50.54%, 64.91% and 1.04 ng/mL, respectively, much higher than HL and WZY when singly used. Furthermore, the activities of acid phosphatase and alkaline phosphatase were significantly increased and the activities of creatine kinase, aldolase and lactate dehydrogenase were reduced in serum, and the expressions of Bax and wild-type p53 proteins were much higher for the mice treated by ZJW compared with HL and WZY single-treatment groups. A clear synergistic effect on the anticancer activity was observed with ZJW, and the mechanism of antitumor growth may be due to an effect on gene expression and activities of tumor markers in serum.
关键词[WOS]: MULTIDRUG-RESISTANCE ;  CANCER-CELLS ;  MECHANISMS ;  BERBERINE ;  APOPTOSIS ;  EXTRACT ;  GROWTH ;  GENES ;  RATS ;  P53
语种: 英语
原文出处: 查看原文
WOS记录号: WOS:000270401600006
Citation statistics: 
内容类型: 期刊论文
URI标识: http://cas-ir.dicp.ac.cn/handle/321008/102205
Appears in Collections:中国科学院大连化学物理研究所_期刊论文

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作者单位: 1.Chinese Acad Sci, Dalian Inst Chem Phys, Natl Chromatog Res & Anal Ctr, Dalian 116023, Peoples R China
2.Dalian Med Univ, Coll Pharm, Dalian, Peoples R China

Recommended Citation:
Wang, Xiao-na,Xu, Li-na,Peng, Jin-yong,et al. In vivo Inhibition of S180 Tumors by the Synergistic Effect of the Chinese Medicinal Herbs Coptis chinensis and Evodia rutaecarpa[J]. PLANTA MEDICA,2009,75(11):1215-1220.
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