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Unexpected reversal of the regioselectivity in Thermomyces lanuginosus lipase-catalyzed acylation of floxuridine
Li, Ning1,2; Zong, Min-Hua1; Ma, Ding2; Minhua Zong; Ma D(马丁)
关键词Enzymatic Acylation Floxuridine Nucleoside Reversal Of Regioselectivity Thermomyces Lanuginosus Lipase
刊名BIOTECHNOLOGY LETTERS
2009-08-01
DOI10.1007/s10529-009-0001-x
31期:8页:1241-1244
收录类别SCI
文章类型Article
部门归属5
项目归属502
产权排名2;1
WOS标题词Science & Technology ; Life Sciences & Biomedicine
类目[WOS]Biotechnology & Applied Microbiology
研究领域[WOS]Biotechnology & Applied Microbiology
关键词[WOS]NUCLEOSIDES ; SOLVENT ; ANALOGS
英文摘要Unexpected inversion of the 3':5'-regioselectivity was observed in the enzymatic methacryloylation, crotonylation and cinnamoylation of floxuridine (1.5:1, 2.3:1 and 4.4:1, respectively), where Thermomyces lanuginosus lipase preferentially catalyzed the acylation of 3'-hydroxyl rather than that of 5'-hydroxyl group. The possible reason might be the presence of a remote interaction between the unsaturated bond in the acyl group and the aromatic ring of amino acid residue Trp89 in the lid of the lipase.
语种英语
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WOS记录号WOS:000268002100018
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文献类型期刊论文
条目标识符http://cas-ir.dicp.ac.cn/handle/321008/102335
专题中国科学院大连化学物理研究所
通讯作者Minhua Zong; Ma D(马丁)
作者单位1.S China Univ Technol, Coll Light Ind & Food Sci, Lab Appl Biocatalysis, Guangzhou 510640, Peoples R China
2.Chinese Acad Sci, Dalian Inst Chem Phys, State Key Lab Catalysis, Dalian 116023, Peoples R China
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Li, Ning,Zong, Min-Hua,Ma, Ding,et al. Unexpected reversal of the regioselectivity in Thermomyces lanuginosus lipase-catalyzed acylation of floxuridine[J]. BIOTECHNOLOGY LETTERS,2009,31(8):1241-1244.
APA Li, Ning,Zong, Min-Hua,Ma, Ding,Minhua Zong,&马丁.(2009).Unexpected reversal of the regioselectivity in Thermomyces lanuginosus lipase-catalyzed acylation of floxuridine.BIOTECHNOLOGY LETTERS,31(8),1241-1244.
MLA Li, Ning,et al."Unexpected reversal of the regioselectivity in Thermomyces lanuginosus lipase-catalyzed acylation of floxuridine".BIOTECHNOLOGY LETTERS 31.8(2009):1241-1244.
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