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Synthesis of phosphodiester-type nicotinamide adenine dinucleotide analogs
Liu, Wujun1,2; Wu, Siguo1,2; Hou, Shuhua1,2; Zhao, Zongbao (Kent)1,3; Zhao ZB(赵宗保)
关键词Nicotinamide Adenine Dinucleotide Coupling Reaction Phosphodiesters Bioorganic Chemistry
刊名TETRAHEDRON
2009-10-03
DOI10.1016/j.tet.2009.08.007
65期:40页:8378-8383
收录类别SCI ; IC
文章类型Article
部门归属18
项目归属1816
产权排名1;1
WOS标题词Science & Technology ; Physical Sciences
类目[WOS]Chemistry, Organic
研究领域[WOS]Chemistry
关键词[WOS]CYCLIC ADP-RIBOSE ; MAMMALIAN-CELLS ; 1,4-NADH DERIVATIVES ; CHEMICAL-SYNTHESIS ; H-PHOSPHONATES ; NAD ; AGENTS ; CHEMISTRY ; PHOSPHATE ; STRATEGY
英文摘要Fourteen phosphodiester-type beta-nicotinamide adenine dinucleotide (NAD+) analogs were prepared starting from nicotinamide. The phosphodiester linkage was effectively assembled in 69-93% yields via condensation reaction between 2'.3'-di-O-acetyl nicotinamide mononucleotide and alcohols in the presence of 2,4,6-triisopropylbenzenesulfonyl chloride. The analog beta-nicotinamide ribose-5-(2-phenylethyl) phosphate showed beneficial effects on cell growth of model microorganisms. (C) 2009 Elsevier Ltd. All rights reserved.
语种英语
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WOS记录号WOS:000269995900010
引用统计
被引频次:3[WOS]   [WOS记录]     [WOS相关记录]
文献类型期刊论文
条目标识符http://cas-ir.dicp.ac.cn/handle/321008/102545
专题中国科学院大连化学物理研究所
通讯作者Zhao ZB(赵宗保)
作者单位1.Chinese Acad Sci, Dalian Inst Chem Phys, Dalian 116023, Peoples R China
2.Chinese Acad Sci, Grad Sch, Beijing 100039, Peoples R China
3.Dalian Natl Lab Clean Energy, Dalian 116023, Peoples R China
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GB/T 7714
Liu, Wujun,Wu, Siguo,Hou, Shuhua,et al. Synthesis of phosphodiester-type nicotinamide adenine dinucleotide analogs[J]. TETRAHEDRON,2009,65(40):8378-8383.
APA Liu, Wujun,Wu, Siguo,Hou, Shuhua,Zhao, Zongbao ,&赵宗保.(2009).Synthesis of phosphodiester-type nicotinamide adenine dinucleotide analogs.TETRAHEDRON,65(40),8378-8383.
MLA Liu, Wujun,et al."Synthesis of phosphodiester-type nicotinamide adenine dinucleotide analogs".TETRAHEDRON 65.40(2009):8378-8383.
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