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题名: Synthesis of phosphodiester-type nicotinamide adenine dinucleotide analogs
作者: Liu, Wujun1, 2;  Wu, Siguo1, 2;  Hou, Shuhua1, 2;  Zhao, Zongbao (Kent)1, 3
通讯作者: 赵宗保
关键词: Nicotinamide adenine dinucleotide ;  Coupling reaction ;  Phosphodiesters ;  Bioorganic chemistry
刊名: TETRAHEDRON
发表日期: 2009-10-03
DOI: 10.1016/j.tet.2009.08.007
卷: 65, 期:40, 页:8378-8383
收录类别: SCI ;  IC
文章类型: Article
部门归属: 18
项目归属: 1816
产权排名: 1;1
WOS标题词: Science & Technology ;  Physical Sciences
类目[WOS]: Chemistry, Organic
研究领域[WOS]: Chemistry
英文摘要: Fourteen phosphodiester-type beta-nicotinamide adenine dinucleotide (NAD+) analogs were prepared starting from nicotinamide. The phosphodiester linkage was effectively assembled in 69-93% yields via condensation reaction between 2'.3'-di-O-acetyl nicotinamide mononucleotide and alcohols in the presence of 2,4,6-triisopropylbenzenesulfonyl chloride. The analog beta-nicotinamide ribose-5-(2-phenylethyl) phosphate showed beneficial effects on cell growth of model microorganisms. (C) 2009 Elsevier Ltd. All rights reserved.
关键词[WOS]: CYCLIC ADP-RIBOSE ;  MAMMALIAN-CELLS ;  1,4-NADH DERIVATIVES ;  CHEMICAL-SYNTHESIS ;  H-PHOSPHONATES ;  NAD ;  AGENTS ;  CHEMISTRY ;  PHOSPHATE ;  STRATEGY
语种: 英语
原文出处: 查看原文
WOS记录号: WOS:000269995900010
Citation statistics: 
内容类型: 期刊论文
URI标识: http://cas-ir.dicp.ac.cn/handle/321008/102545
Appears in Collections:中国科学院大连化学物理研究所_期刊论文

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作者单位: 1.Chinese Acad Sci, Dalian Inst Chem Phys, Dalian 116023, Peoples R China
2.Chinese Acad Sci, Grad Sch, Beijing 100039, Peoples R China
3.Dalian Natl Lab Clean Energy, Dalian 116023, Peoples R China

Recommended Citation:
Liu, Wujun,Wu, Siguo,Hou, Shuhua,et al. Synthesis of phosphodiester-type nicotinamide adenine dinucleotide analogs[J]. TETRAHEDRON,2009,65(40):8378-8383.
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