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题名: Fingerprint analysis of Ligusticum chuanxiong using hydrophilic interaction chromatography and reversed-phase liquid chromatography
作者: Jin, Yu1;  Liang, Tu1;  Fu, Qing1;  Xiao, Yuan-Sheng1;  Feng, Jia-Tao1;  Ke, Yan-Xiong2;  Liang, Xin-Miao1, 2
通讯作者: 梁鑫淼
关键词: Fingerprint analysis ;  Quality control ;  Ligusticum chuanxiong ;  Hydrophilic interaction chromatography ;  (HILIC) ;  Reversed-phase liquid chromatography ;  (RPLC) ;  Polar compounds
刊名: JOURNAL OF CHROMATOGRAPHY A
发表日期: 2009-03-13
DOI: 10.1016/j.chroma.2008.04.010
卷: 1216, 期:11, 页:2136-2141
收录类别: SCI
文章类型: Article
部门归属: 18
项目归属: 1803
产权排名: 1;1
WOS标题词: Science & Technology ;  Life Sciences & Biomedicine ;  Physical Sciences
类目[WOS]: Biochemical Research Methods ;  Chemistry, Analytical
研究领域[WOS]: Biochemistry & Molecular Biology ;  Chemistry
英文摘要: Fingerprint analysis is considered one of the most powerful approaches to quality control in traditional Chinese medicines (TCMs). In this study, a binary chromatographic fingerprint analysis was developed using hydrophilic interaction chromatography (HILIC) and reversed-phase liquid chromatography (RPLC) to gain more chemical information about polar compounds and weakly polar compounds. This method was used to construct a chromatographic fingerprint of Ligusticum chuanxiong. The two chromatographic methods demonstrated good precision, reproducibility, and stability, with relative standard deviations of <2% for retention time and 7% for peak area for both HILIC and RPLC separations. Data from the analysis of 14 samples by HILIC and RPLC were processed with similarity analysis, with correlation coefficients and congruence coefficients. This binary fingerprint analysis, using two chromatographic modes, is a powerful tool for characterizing the quality of samples, and can be used for the comprehensive quality control of TCMs. (C) 2008 Elsevier B.V. All rights reserved.
关键词[WOS]: ELECTROSPRAY MASS-SPECTROMETRY ;  DIODE-ARRAY DETECTION ;  QUALITY-CONTROL ;  POLAR COMPOUNDS ;  MEDICINAL-PLANTS ;  HERBAL MEDICINES ;  HPLC ;  RHIZOMA ;  DAD ;  IDENTIFICATION
语种: 英语
原文出处: 查看原文
WOS记录号: WOS:000264226500021
Citation statistics: 
内容类型: 期刊论文
URI标识: http://cas-ir.dicp.ac.cn/handle/321008/102577
Appears in Collections:中国科学院大连化学物理研究所_期刊论文

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作者单位: 1.Chinese Acad Sci, Dalian Inst Chem Phys, Grad Sch, Dalian 116023, Peoples R China
2.E China Univ Sci & Technol, Sch Pharm, Shanghai 200237, Peoples R China

Recommended Citation:
Jin, Yu,Liang, Tu,Fu, Qing,et al. Fingerprint analysis of Ligusticum chuanxiong using hydrophilic interaction chromatography and reversed-phase liquid chromatography[J]. JOURNAL OF CHROMATOGRAPHY A,2009,1216(11):2136-2141.
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