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Fingerprint analysis of Ligusticum chuanxiong using hydrophilic interaction chromatography and reversed-phase liquid chromatography
Jin, Yu1; Liang, Tu1; Fu, Qing1; Xiao, Yuan-Sheng1; Feng, Jia-Tao1; Ke, Yan-Xiong2; Liang, Xin-Miao1,2; Liang XM(梁鑫淼)
KeywordFingerprint Analysis Quality Control Ligusticum Chuanxiong Hydrophilic Interaction Chromatography (Hilic) Reversed-phase Liquid Chromatography (Rplc) Polar Compounds
Source PublicationJOURNAL OF CHROMATOGRAPHY A
2009-03-13
DOI10.1016/j.chroma.2008.04.010
Volume1216Issue:11Pages:2136-2141
Indexed BySCI
SubtypeArticle
Department18
Funding Project1803
Contribution Rank1;1
WOS HeadingsScience & Technology ; Life Sciences & Biomedicine ; Physical Sciences
WOS SubjectBiochemical Research Methods ; Chemistry, Analytical
WOS Research AreaBiochemistry & Molecular Biology ; Chemistry
WOS KeywordELECTROSPRAY MASS-SPECTROMETRY ; DIODE-ARRAY DETECTION ; QUALITY-CONTROL ; POLAR COMPOUNDS ; MEDICINAL-PLANTS ; HERBAL MEDICINES ; HPLC ; RHIZOMA ; DAD ; IDENTIFICATION
AbstractFingerprint analysis is considered one of the most powerful approaches to quality control in traditional Chinese medicines (TCMs). In this study, a binary chromatographic fingerprint analysis was developed using hydrophilic interaction chromatography (HILIC) and reversed-phase liquid chromatography (RPLC) to gain more chemical information about polar compounds and weakly polar compounds. This method was used to construct a chromatographic fingerprint of Ligusticum chuanxiong. The two chromatographic methods demonstrated good precision, reproducibility, and stability, with relative standard deviations of <2% for retention time and 7% for peak area for both HILIC and RPLC separations. Data from the analysis of 14 samples by HILIC and RPLC were processed with similarity analysis, with correlation coefficients and congruence coefficients. This binary fingerprint analysis, using two chromatographic modes, is a powerful tool for characterizing the quality of samples, and can be used for the comprehensive quality control of TCMs. (C) 2008 Elsevier B.V. All rights reserved.
Language英语
URL查看原文
WOS IDWOS:000264226500021
Citation statistics
Cited Times:53[WOS]   [WOS Record]     [Related Records in WOS]
Document Type期刊论文
Identifierhttp://cas-ir.dicp.ac.cn/handle/321008/102577
Collection中国科学院大连化学物理研究所
Corresponding AuthorLiang XM(梁鑫淼)
Affiliation1.Chinese Acad Sci, Dalian Inst Chem Phys, Grad Sch, Dalian 116023, Peoples R China
2.E China Univ Sci & Technol, Sch Pharm, Shanghai 200237, Peoples R China
Recommended Citation
GB/T 7714
Jin, Yu,Liang, Tu,Fu, Qing,et al. Fingerprint analysis of Ligusticum chuanxiong using hydrophilic interaction chromatography and reversed-phase liquid chromatography[J]. JOURNAL OF CHROMATOGRAPHY A,2009,1216(11):2136-2141.
APA Jin, Yu.,Liang, Tu.,Fu, Qing.,Xiao, Yuan-Sheng.,Feng, Jia-Tao.,...&梁鑫淼.(2009).Fingerprint analysis of Ligusticum chuanxiong using hydrophilic interaction chromatography and reversed-phase liquid chromatography.JOURNAL OF CHROMATOGRAPHY A,1216(11),2136-2141.
MLA Jin, Yu,et al."Fingerprint analysis of Ligusticum chuanxiong using hydrophilic interaction chromatography and reversed-phase liquid chromatography".JOURNAL OF CHROMATOGRAPHY A 1216.11(2009):2136-2141.
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