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Analysis of highly polar metabolites in human plasma by ultra-performance hydrophilic interaction liquid chromatography coupled with quadrupole-time of flight mass spectrometry
Cai, Xiaoming1; Zou, Lijuan1,2; Dong, Jun1; Zhao, Lili2; Wang, Yuanyuan2; Xu, Qing1; Xue, Xingya1; Zhang, Xiuli1; Liang, Xinmiao1; Liang XM(梁鑫淼)
关键词Hydrophilic Interaction Liquid Chromatography Plasma Metabonomics Highly Polar Metabolites
刊名ANALYTICA CHIMICA ACTA
2009-09-14
DOI10.1016/j.aca.2009.01.054
650期:1页:10-15
收录类别SCI
文章类型Article
部门归属18
项目归属1803
产权排名1;1
WOS标题词Science & Technology ; Physical Sciences
类目[WOS]Chemistry, Analytical
研究领域[WOS]Chemistry
关键词[WOS]MULTIVARIATE STATISTICAL-ANALYSIS ; PROTEIN PRECIPITATION ; RAT URINE ; METABONOMICS ; SEPARATION ; MS ; SPECTROSCOPY ; AGE
英文摘要Highly polar metabolites are abundant in human plasma. Analysis of these compounds by standard reverse-phase chromatography is difficult. Highly polar metabolites were extracted by a two-step method. They were analyzed by ultra-performance hydrophilic interaction chromatography (HILIC) coupled to quadrupole-time of flight mass spectrometer detection technology. The middle and low polar fraction were also analyzed using a standard C18 column. Data were extracted by Markerlynx, and analyzed by multivariate statistical methods to discriminate human plasma samples by sex and age. The results not only showed good classification of samples by sex and age, but also revealed new potential biomarkers not revealed by standard RPLC/MS analysis. This study showed that HILIC is an effective technique to analyze highly polar metabolites for metabonomic studies. (C) 2009 Elsevier B.V. All rights reserved.
语种英语
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WOS记录号WOS:000270003800003
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被引频次:49[WOS]   [WOS记录]     [WOS相关记录]
文献类型期刊论文
条目标识符http://cas-ir.dicp.ac.cn/handle/321008/102583
专题中国科学院大连化学物理研究所
通讯作者Liang XM(梁鑫淼)
作者单位1.Chinese Acad Sci, Dalian Inst Chem Phys, Grad Sch, Dalian 116023, Peoples R China
2.Dalian Med Univ, Hosp 2, Dalian 116023, Peoples R China
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GB/T 7714
Cai, Xiaoming,Zou, Lijuan,Dong, Jun,et al. Analysis of highly polar metabolites in human plasma by ultra-performance hydrophilic interaction liquid chromatography coupled with quadrupole-time of flight mass spectrometry[J]. ANALYTICA CHIMICA ACTA,2009,650(1):10-15.
APA Cai, Xiaoming.,Zou, Lijuan.,Dong, Jun.,Zhao, Lili.,Wang, Yuanyuan.,...&梁鑫淼.(2009).Analysis of highly polar metabolites in human plasma by ultra-performance hydrophilic interaction liquid chromatography coupled with quadrupole-time of flight mass spectrometry.ANALYTICA CHIMICA ACTA,650(1),10-15.
MLA Cai, Xiaoming,et al."Analysis of highly polar metabolites in human plasma by ultra-performance hydrophilic interaction liquid chromatography coupled with quadrupole-time of flight mass spectrometry".ANALYTICA CHIMICA ACTA 650.1(2009):10-15.
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