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题名: UPLC/Q-TOFMS/MS as a powerful technique for rapid identification of polymethoxylated flavones in Fructus aurantii
作者: Zhou, Da-Yong2;  Zhang, Xiu-Li1;  Xu, Qing1;  Xue, Xing-Ya1;  Zhang, Fei-Fang1;  Liang, Xin-Miao1
通讯作者: 张秀莉
关键词: UPLC ;  Q-TOFMS/MS ;  PMFs ;  Fructus aurantii ;  Rapid identification ;  Mass spectrometric fingerprint
刊名: JOURNAL OF PHARMACEUTICAL AND BIOMEDICAL ANALYSIS
发表日期: 2009-08-15
DOI: 10.1016/j.jpba.2009.03.010
卷: 50, 期:1, 页:2-8
收录类别: SCI
文章类型: Article
部门归属: 18
项目归属: 1803
产权排名: 2;2
WOS标题词: Science & Technology ;  Physical Sciences ;  Life Sciences & Biomedicine
类目[WOS]: Chemistry, Analytical ;  Pharmacology & Pharmacy
研究领域[WOS]: Chemistry ;  Pharmacology & Pharmacy
英文摘要: Polymethoxylated flavones (PMFs), as potential cancer chemopreventive agents, are widely distributed in Citrus genus. In this study, a selected ion monitoring-tandem mass (SIM-MS/MS) method for the rapid identification of PMFs in Fructus aurantii (E aurantii) with ultra-performance liquid chromatography (UPLC) coupled to quadrupole, hybrid orthogonal acceleration time-of-flight tandem mass spectrometer (Q-TOFMS/MS) was proposed. The MS data for candidates, containing accurate mass and isotopic patterns for both precursors and their fragment ions, were acquired selectively. Based on the MS data, the mass spectrometric fingerprint (MSFP) for candidates, consisting of chemical formula and dissociation pattern, was determined. Comparing the MSFPs of the observed compounds with the diagnostic MSFP of the species, 44 PMFs were tentatively identified. The method was validated by tangeretin and sinensetin, two representative compounds of PMFs, and was considered to be suitable for the rapid screening of PMFs in crude and partially purified samples. (C) 2009 Elsevier B.V. All rights reserved.
关键词[WOS]: SQUAMOUS-CELL CARCINOMA ;  LIQUID-CHROMATOGRAPHY ;  MASS-SPECTROMETRY
语种: 英语
原文出处: 查看原文
WOS记录号: WOS:000266683700001
Citation statistics: 
内容类型: 期刊论文
URI标识: http://cas-ir.dicp.ac.cn/handle/321008/102617
Appears in Collections:中国科学院大连化学物理研究所_期刊论文

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作者单位: 1.Chinese Acad Sci, Dalian Inst Chem Phys, Dalian 116023, Peoples R China
2.Dalian Polytech Univ, Coll Biol & Food Technol, Dalian 116034, Peoples R China

Recommended Citation:
Zhou, Da-Yong,Zhang, Xiu-Li,Xu, Qing,et al. UPLC/Q-TOFMS/MS as a powerful technique for rapid identification of polymethoxylated flavones in Fructus aurantii[J]. JOURNAL OF PHARMACEUTICAL AND BIOMEDICAL ANALYSIS,2009,50(1):2-8.
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