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题名: Characterization of polymethoxylated flavones in Fructus aurantii by off-line two-dimensional liquid chromatography/electrospray ionization-ion trap mass spectrometry
作者: Zhou, Da-Yong2;  Xu, Qing1;  Xue, Xing-Ya1;  Zhang, Fei-Fang1;  Liang, Xin-Miao1
通讯作者: 梁鑫淼
关键词: 2D-LC ;  ESI-ITMS ;  Fructus aurantii ;  Matrix effects ;  Polymethoxylated flavones
刊名: JOURNAL OF PHARMACEUTICAL AND BIOMEDICAL ANALYSIS
发表日期: 2009-02-20
DOI: 10.1016/j.jpba.2008.10.044
卷: 49, 期:2, 页:207-213
收录类别: SCI
文章类型: Article
部门归属: 18
项目归属: 1803
产权排名: 2;2
WOS标题词: Science & Technology ;  Physical Sciences ;  Life Sciences & Biomedicine
类目[WOS]: Chemistry, Analytical ;  Pharmacology & Pharmacy
研究领域[WOS]: Chemistry ;  Pharmacology & Pharmacy
英文摘要: Off-line two-dimensional reversed-phase liquid chromatography (2D-RPLC) coupled to electrospray ionization-ion trap mass spectrometry (ESI-ITMS) was operated in positive mode (PI) to characterize polymethoxylated flavonoids (PMFs) in botanical sample. The fragments of [M+H-nx15](+) produced by loss of one or more methyl group from the protonated molecules, as well as [M+H-14](+), [M+H-29](+), [M+H-33](+), [M+H-43](+), [M+H-46](+) and [M+H-61](+) fragments formed the Multiple MS (MS(n)) "fingerprint" of PMFs. 42 target compounds were tentatively identified from the extract of Fructus aurantii (F. aurontii) based on this "fingerprint". Experimental outcomes indicated that the application of 2D separation method can reduce the matrix suppression of analytes caused by the coelution with interferential components and the column overloading of interferential components. 42 versus 23 target compounds were detected through 2D versus 1 D method, which confirm the superiority of 2D coupled to MS in elimination of matrix effects. (c) 2008 Elsevier B.V. All rights reserved.
关键词[WOS]: TRADITIONAL CHINESE MEDICINES ;  SEPARATION ;  PERFORMANCE ;  LC ;  IDENTIFICATION ;  INTEGRATION ;  MS
语种: 英语
原文出处: 查看原文
WOS记录号: WOS:000263434900005
Citation statistics: 
内容类型: 期刊论文
URI标识: http://cas-ir.dicp.ac.cn/handle/321008/102679
Appears in Collections:中国科学院大连化学物理研究所_期刊论文

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作者单位: 1.Chinese Acad Sci, Dalian Inst Chem Phys, Dalian 116023, Peoples R China
2.Dalian Polytech Univ, Coll Bio & Food Technol, Dalian 116034, Peoples R China

Recommended Citation:
Zhou, Da-Yong,Xu, Qing,Xue, Xing-Ya,et al. Characterization of polymethoxylated flavones in Fructus aurantii by off-line two-dimensional liquid chromatography/electrospray ionization-ion trap mass spectrometry[J]. JOURNAL OF PHARMACEUTICAL AND BIOMEDICAL ANALYSIS,2009,49(2):207-213.
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