DICP OpenIR
Quality and safety of Chinese herbal medicines guided by a systems biology perspective
Wang, Jiangshan3,4,7; van der Heijden, Rob4; Spruit, Shannon1,2; Hankermeier, Thomas4; Chan, Kelvin5,6; van der Greef, Jan1,2,4,7; Xu, Guowang3,7; Wang, Mei1,2,7; Xu GW(许国旺)
KeywordChinese Materia Medica Systems Biology Systems Toxicology Metabolomics Aconitum Roots
Source PublicationJOURNAL OF ETHNOPHARMACOLOGY
2009-10-29
DOI10.1016/j.jep.2009.07.040
Volume126Issue:1Pages:31-41
Indexed BySCI
SubtypeReview
Department18
Funding Project1808
Contribution Rank1;1
WOS HeadingsScience & Technology ; Life Sciences & Biomedicine
WOS SubjectPlant Sciences ; Chemistry, Medicinal ; Integrative & Complementary Medicine ; Pharmacology & Pharmacy
WOS Research AreaPlant Sciences ; Pharmacology & Pharmacy ; Integrative & Complementary Medicine
WOS KeywordSEVERE MYOCLONIC EPILEPSY ; MASS-SPECTROMETRY ; DRUG SAFETY ; ARISTOLOCHIC ACID ; FIELD-DESORPTION ; ACONITUM ; TOXICITY ; ALKALOIDS ; PHARMACOLOGY ; MUTATIONS
AbstractChinese herbal medicines, often referred as Chinese materia medica (CMM), are comprised of a complex multicomponent nature. The activities are aimed at the system level via interactions with a Multitude of targets in the human body. This review aims at the toxicity aspects of CMM and its preparations at the different steps of production; harvesting, processing and the final formulation. The historic perspective and today's issues of the safety of CMM are introduced briefly, followed by the descriptions of the toxic CMM in the Current Chinese Pharmacopoeia (2005). subsequently, several aspects of safety are illustrated using a typical example of a toxic CMM, Aconitum roots, and some recent findings of our Own research are included to illustrate that proper processing and multi-herbs formulation can reduce the level of toxic components. This also explains that in CMM, some herbs, Such as Aconitum, Ephedra species are never used as single herb for intervention and that aconite is only used when it is processed and in combination with specific matched other herbs. The formulation principle of multi-herbs intervention strategy is a systems approach for the treatment and prevention of disease. In this light, the role of systems toxicology in the safety and quality of Chinese herbal medicine is proposed as a promising method. Moreover the principles of practiced-based and evidence-based research are discussed from a symbiotic perspective. (C) 2009 Elsevier Ireland Ltd. All rights reserved.
Language英语
URL查看原文
WOS IDWOS:000271790800003
Citation statistics
Cited Times:82[WOS]   [WOS Record]     [Related Records in WOS]
Document Type期刊论文
Identifierhttp://cas-ir.dicp.ac.cn/handle/321008/102729
Collection中国科学院大连化学物理研究所
Corresponding AuthorXu GW(许国旺)
Affiliation1.SU BioMed, NL-3700 AJ Zeist, Netherlands
2.TNO, Qual Life, NL-3700 AJ Zeist, Netherlands
3.Chinese Acad Sci, Dalian Inst Chem Phys, Key Lab Separat Sci Analyt Chem, Dalian 116023, Peoples R China
4.Leiden Univ, Leiden Amsterdam Ctr Drug Res, Div Analyt Biosci, NL-2300 RA Leiden, Netherlands
5.Wolverhampton Univ, Sch Appl Sci, Res Inst Healthcare Sci, Wolverhampton WV1 1LY, England
6.Wolverhampton Univ, Dept Pharm, Wolverhampton WV1 1LY, England
7.Sino Dutch Ctr Prevent & Personalized Med, NL-3700 AJ Zeist, Netherlands
Recommended Citation
GB/T 7714
Wang, Jiangshan,van der Heijden, Rob,Spruit, Shannon,et al. Quality and safety of Chinese herbal medicines guided by a systems biology perspective[J]. JOURNAL OF ETHNOPHARMACOLOGY,2009,126(1):31-41.
APA Wang, Jiangshan.,van der Heijden, Rob.,Spruit, Shannon.,Hankermeier, Thomas.,Chan, Kelvin.,...&许国旺.(2009).Quality and safety of Chinese herbal medicines guided by a systems biology perspective.JOURNAL OF ETHNOPHARMACOLOGY,126(1),31-41.
MLA Wang, Jiangshan,et al."Quality and safety of Chinese herbal medicines guided by a systems biology perspective".JOURNAL OF ETHNOPHARMACOLOGY 126.1(2009):31-41.
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