中国科学院大连化学物理研究所机构知识库
Advanced  
DICP OpenIR  > 中国科学院大连化学物理研究所  > 期刊论文
题名: Quality and safety of Chinese herbal medicines guided by a systems biology perspective
作者: Wang, Jiangshan3, 4, 7;  van der Heijden, Rob4;  Spruit, Shannon1, 2;  Hankermeier, Thomas4;  Chan, Kelvin5, 6;  van der Greef, Jan1, 2, 4, 7;  Xu, Guowang3, 7;  Wang, Mei1, 2, 7
通讯作者: 许国旺
关键词: Chinese materia medica ;  Systems biology ;  Systems toxicology ;  Metabolomics ;  Aconitum roots
刊名: JOURNAL OF ETHNOPHARMACOLOGY
发表日期: 2009-10-29
DOI: 10.1016/j.jep.2009.07.040
卷: 126, 期:1, 页:31-41
收录类别: SCI
文章类型: Review
部门归属: 18
项目归属: 1808
产权排名: 1;1
WOS标题词: Science & Technology ;  Life Sciences & Biomedicine
类目[WOS]: Plant Sciences ;  Chemistry, Medicinal ;  Integrative & Complementary Medicine ;  Pharmacology & Pharmacy
研究领域[WOS]: Plant Sciences ;  Pharmacology & Pharmacy ;  Integrative & Complementary Medicine
英文摘要: Chinese herbal medicines, often referred as Chinese materia medica (CMM), are comprised of a complex multicomponent nature. The activities are aimed at the system level via interactions with a Multitude of targets in the human body. This review aims at the toxicity aspects of CMM and its preparations at the different steps of production; harvesting, processing and the final formulation. The historic perspective and today's issues of the safety of CMM are introduced briefly, followed by the descriptions of the toxic CMM in the Current Chinese Pharmacopoeia (2005). subsequently, several aspects of safety are illustrated using a typical example of a toxic CMM, Aconitum roots, and some recent findings of our Own research are included to illustrate that proper processing and multi-herbs formulation can reduce the level of toxic components. This also explains that in CMM, some herbs, Such as Aconitum, Ephedra species are never used as single herb for intervention and that aconite is only used when it is processed and in combination with specific matched other herbs. The formulation principle of multi-herbs intervention strategy is a systems approach for the treatment and prevention of disease. In this light, the role of systems toxicology in the safety and quality of Chinese herbal medicine is proposed as a promising method. Moreover the principles of practiced-based and evidence-based research are discussed from a symbiotic perspective. (C) 2009 Elsevier Ireland Ltd. All rights reserved.
关键词[WOS]: SEVERE MYOCLONIC EPILEPSY ;  MASS-SPECTROMETRY ;  DRUG SAFETY ;  ARISTOLOCHIC ACID ;  FIELD-DESORPTION ;  ACONITUM ;  TOXICITY ;  ALKALOIDS ;  PHARMACOLOGY ;  MUTATIONS
语种: 英语
原文出处: 查看原文
WOS记录号: WOS:000271790800003
Citation statistics: 
内容类型: 期刊论文
URI标识: http://cas-ir.dicp.ac.cn/handle/321008/102729
Appears in Collections:中国科学院大连化学物理研究所_期刊论文

Files in This Item:

There are no files associated with this item.


作者单位: 1.SU BioMed, NL-3700 AJ Zeist, Netherlands
2.TNO, Qual Life, NL-3700 AJ Zeist, Netherlands
3.Chinese Acad Sci, Dalian Inst Chem Phys, Key Lab Separat Sci Analyt Chem, Dalian 116023, Peoples R China
4.Leiden Univ, Leiden Amsterdam Ctr Drug Res, Div Analyt Biosci, NL-2300 RA Leiden, Netherlands
5.Wolverhampton Univ, Sch Appl Sci, Res Inst Healthcare Sci, Wolverhampton WV1 1LY, England
6.Wolverhampton Univ, Dept Pharm, Wolverhampton WV1 1LY, England
7.Sino Dutch Ctr Prevent & Personalized Med, NL-3700 AJ Zeist, Netherlands

Recommended Citation:
Wang, Jiangshan,van der Heijden, Rob,Spruit, Shannon,et al. Quality and safety of Chinese herbal medicines guided by a systems biology perspective[J]. JOURNAL OF ETHNOPHARMACOLOGY,2009,126(1):31-41.
Service
 Recommend this item
 Sava as my favorate item
 Show this item's statistics
 Export Endnote File
Google Scholar
 Similar articles in Google Scholar
 [Wang, Jiangshan]'s Articles
 [van der Heijden, Rob]'s Articles
 [Spruit, Shannon]'s Articles
CSDL cross search
 Similar articles in CSDL Cross Search
 [Wang, Jiangshan]‘s Articles
 [van der Heijden, Rob]‘s Articles
 [Spruit, Shannon]‘s Articles
Related Copyright Policies
Null
Social Bookmarking
  Add to CiteULike  Add to Connotea  Add to Del.icio.us  Add to Digg  Add to Reddit 
所有评论 (0)
暂无评论
 
评注功能仅针对注册用户开放,请您登录
您对该条目有什么异议,请填写以下表单,管理员会尽快联系您。
内 容:
Email:  *
单位:
验证码:   刷新
您在IR的使用过程中有什么好的想法或者建议可以反馈给我们。
标 题:
 *
内 容:
Email:  *
验证码:   刷新

Items in IR are protected by copyright, with all rights reserved, unless otherwise indicated.

 

 

Valid XHTML 1.0!
Powered by CSpace