DICP OpenIR
Quality and safety of Chinese herbal medicines guided by a systems biology perspective
Wang, Jiangshan3,4,7; van der Heijden, Rob4; Spruit, Shannon1,2; Hankermeier, Thomas4; Chan, Kelvin5,6; van der Greef, Jan1,2,4,7; Xu, Guowang3,7; Wang, Mei1,2,7; Xu GW(许国旺)
关键词Chinese Materia Medica Systems Biology Systems Toxicology Metabolomics Aconitum Roots
刊名JOURNAL OF ETHNOPHARMACOLOGY
2009-10-29
DOI10.1016/j.jep.2009.07.040
126期:1页:31-41
收录类别SCI
文章类型Review
部门归属18
项目归属1808
产权排名1;1
WOS标题词Science & Technology ; Life Sciences & Biomedicine
类目[WOS]Plant Sciences ; Chemistry, Medicinal ; Integrative & Complementary Medicine ; Pharmacology & Pharmacy
研究领域[WOS]Plant Sciences ; Pharmacology & Pharmacy ; Integrative & Complementary Medicine
关键词[WOS]SEVERE MYOCLONIC EPILEPSY ; MASS-SPECTROMETRY ; DRUG SAFETY ; ARISTOLOCHIC ACID ; FIELD-DESORPTION ; ACONITUM ; TOXICITY ; ALKALOIDS ; PHARMACOLOGY ; MUTATIONS
英文摘要Chinese herbal medicines, often referred as Chinese materia medica (CMM), are comprised of a complex multicomponent nature. The activities are aimed at the system level via interactions with a Multitude of targets in the human body. This review aims at the toxicity aspects of CMM and its preparations at the different steps of production; harvesting, processing and the final formulation. The historic perspective and today's issues of the safety of CMM are introduced briefly, followed by the descriptions of the toxic CMM in the Current Chinese Pharmacopoeia (2005). subsequently, several aspects of safety are illustrated using a typical example of a toxic CMM, Aconitum roots, and some recent findings of our Own research are included to illustrate that proper processing and multi-herbs formulation can reduce the level of toxic components. This also explains that in CMM, some herbs, Such as Aconitum, Ephedra species are never used as single herb for intervention and that aconite is only used when it is processed and in combination with specific matched other herbs. The formulation principle of multi-herbs intervention strategy is a systems approach for the treatment and prevention of disease. In this light, the role of systems toxicology in the safety and quality of Chinese herbal medicine is proposed as a promising method. Moreover the principles of practiced-based and evidence-based research are discussed from a symbiotic perspective. (C) 2009 Elsevier Ireland Ltd. All rights reserved.
语种英语
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WOS记录号WOS:000271790800003
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被引频次:79[WOS]   [WOS记录]     [WOS相关记录]
文献类型期刊论文
条目标识符http://cas-ir.dicp.ac.cn/handle/321008/102729
专题中国科学院大连化学物理研究所
通讯作者Xu GW(许国旺)
作者单位1.SU BioMed, NL-3700 AJ Zeist, Netherlands
2.TNO, Qual Life, NL-3700 AJ Zeist, Netherlands
3.Chinese Acad Sci, Dalian Inst Chem Phys, Key Lab Separat Sci Analyt Chem, Dalian 116023, Peoples R China
4.Leiden Univ, Leiden Amsterdam Ctr Drug Res, Div Analyt Biosci, NL-2300 RA Leiden, Netherlands
5.Wolverhampton Univ, Sch Appl Sci, Res Inst Healthcare Sci, Wolverhampton WV1 1LY, England
6.Wolverhampton Univ, Dept Pharm, Wolverhampton WV1 1LY, England
7.Sino Dutch Ctr Prevent & Personalized Med, NL-3700 AJ Zeist, Netherlands
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GB/T 7714
Wang, Jiangshan,van der Heijden, Rob,Spruit, Shannon,et al. Quality and safety of Chinese herbal medicines guided by a systems biology perspective[J]. JOURNAL OF ETHNOPHARMACOLOGY,2009,126(1):31-41.
APA Wang, Jiangshan.,van der Heijden, Rob.,Spruit, Shannon.,Hankermeier, Thomas.,Chan, Kelvin.,...&许国旺.(2009).Quality and safety of Chinese herbal medicines guided by a systems biology perspective.JOURNAL OF ETHNOPHARMACOLOGY,126(1),31-41.
MLA Wang, Jiangshan,et al."Quality and safety of Chinese herbal medicines guided by a systems biology perspective".JOURNAL OF ETHNOPHARMACOLOGY 126.1(2009):31-41.
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