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题名: Intravenous Fentanyl is Exhaled and the Concentration Fluctuates with Time
作者: Wang, H.1;  Li, E. Y.1;  Xu, G. W.2;  Wang, C. S.1;  Gong, Y. L.1;  Li, P.1
通讯作者: 李恩有
关键词: FENTANYL ;  OPIOID ;  ANAESTHETICS ;  PHARMACOKINETICS ;  ELIMINATION ;  EXHALATION
刊名: JOURNAL OF INTERNATIONAL MEDICAL RESEARCH
发表日期: 2009-07-01
卷: 37, 期:4, 页:1158-1166
收录类别: SCI
文章类型: Article
部门归属: 18
项目归属: 1808
产权排名: 2;3
WOS标题词: Science & Technology ;  Life Sciences & Biomedicine
类目[WOS]: Medicine, Research & Experimental ;  Pharmacology & Pharmacy
研究领域[WOS]: Research & Experimental Medicine ;  Pharmacology & Pharmacy
英文摘要: Previous studies have reported that fentanyl is eliminated predominantly by hepatic biotransformation, and that some is eliminated unchanged in urine and stools. No reports have described the elimination of fentanyl via the lungs. In this study, exhaled gas samples from eight anaesthetized patients undergoing cardiac surgery were analysed using solid-phase microextraction (SPME) coupled with gas chromatography-mass spectrometry (GC-MS). Results confirmed that fentanyl was exhaled by patients after intravenous administration, that the concentration of exhaled fentanyl fluctuated with time and peak concentrations were reached approximately 15 - 20 min after intravenous fentanyl administration. Thus, in addition to hepatic biotransformation and elimination via urine and faeces, fentanyl is also eliminated unchanged by the lungs. The potential risk to operating theatre personnel from long-term exposure to low levels of exhaled anaesthetic agents following intravenous administration to patients during surgery warrants further research.
关键词[WOS]: CHROMATOGRAPHY-MASS SPECTROMETRY ;  SOLID-PHASE MICROEXTRACTION ;  HUMAN PLASMA ;  GAS ;  ALFENTANIL ;  PROPOFOL ;  ANESTHESIOLOGISTS ;  SUFENTANIL ;  ADDICTION ;  KINETICS
语种: 英语
原文出处: 查看原文
WOS记录号: WOS:000271036300021
Citation statistics: 
内容类型: 期刊论文
URI标识: http://cas-ir.dicp.ac.cn/handle/321008/102733
Appears in Collections:中国科学院大连化学物理研究所_期刊论文

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作者单位: 1.Harbin Med Univ, Dept Anaesthesiol, Affiliated Hosp 1, Harbin 150001, Heilongjiang, Peoples R China
2.Chinese Acad Sci, Dalian Inst Chem Phys, Natl Chromatog Res & Anal Ctr, Dalian, Liaoning, Peoples R China

Recommended Citation:
Wang, H.,Li, E. Y.,Xu, G. W.,et al. Intravenous Fentanyl is Exhaled and the Concentration Fluctuates with Time[J]. JOURNAL OF INTERNATIONAL MEDICAL RESEARCH,2009,37(4):1158-1166.
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