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题名: Characterization of cardamonin metabolism by P450 in different species via HPLC-ESI-ion trap and UPLC-ESI-quadrupole mass spectrometry
作者: He, Yu-qi2;  Yang, Li2;  Liu, Yong1;  Zhang, Jiang-wei1;  Tang, Jun3;  Su, Juan2;  Li, Yuan-yuan2;  Lu, Yan-liu2;  Wang, Chang-hong2;  Yang, Ling1;  Wang, Zheng-tao2
通讯作者: 杨凌 ;  王峥涛
关键词: cardamonin ;  metabolism ;  P450 ;  human liver microsome ;  species difference
刊名: ACTA PHARMACOLOGICA SINICA
发表日期: 2009-10-01
DOI: 10.1038/aps.2009.127
卷: 30, 期:10, 页:1462-1470
收录类别: SCI
文章类型: Article
部门归属: 18
项目归属: 1806
产权排名: 2;3
WOS标题词: Science & Technology ;  Physical Sciences ;  Life Sciences & Biomedicine
类目[WOS]: Chemistry, Multidisciplinary ;  Pharmacology & Pharmacy
研究领域[WOS]: Chemistry ;  Pharmacology & Pharmacy
英文摘要: Aim: To characterize the metabolism of cardamonin by the P450 enzymes in human and animal liver microsomes.
关键词[WOS]: VITRO CYTOCHROME-P450 INHIBITION ;  HUMAN LIVER-MICROSOMES ;  IN-VITRO ;  DRUG-INTERACTIONS ;  SIGNALING PATHWAYS ;  RAT-LIVER ;  VIVO ;  CHROMATOGRAPHY ;  PREDICTION ;  CLEARANCE
语种: 英语
原文出处: 查看原文
WOS记录号: WOS:000270733600011
Citation statistics: 
内容类型: 期刊论文
URI标识: http://cas-ir.dicp.ac.cn/handle/321008/102945
Appears in Collections:中国科学院大连化学物理研究所_期刊论文

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作者单位: 1.Chinese Acad Sci, Lab Pharmaceut Resource Discovery, Dalian Inst Chem Phys, Dalian 116023, Peoples R China
2.Shanghai Univ Tradit Chinese Med, MOE Key Lab Standardizat Chinese Med, Inst Chinese Mat Med, Shanghai 201210, Peoples R China
3.Wuhan Univ, Coll Pharm, Wuhan 430072, Peoples R China

Recommended Citation:
He, Yu-qi,Yang, Li,Liu, Yong,et al. Characterization of cardamonin metabolism by P450 in different species via HPLC-ESI-ion trap and UPLC-ESI-quadrupole mass spectrometry[J]. ACTA PHARMACOLOGICA SINICA,2009,30(10):1462-1470.
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