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题名: Selectively preparative purification of aristolochic acids and aristololactams from Aristolochia plants
作者: Zhang, Jing1;  Xiao, Yuansheng1;  Feng, Jiatao1;  Wu, Sophia L.2;  Xue, Xingya1;  Zhang, Xiuli1;  Liang, Xinmiao1
通讯作者: 肖远胜 ;  张秀莉
关键词: Oligo (ethylene glycol) ;  Preparative HPLC ;  Auto-purification Factory ;  Aristolochic acids ;  Aristololactams
刊名: JOURNAL OF PHARMACEUTICAL AND BIOMEDICAL ANALYSIS
发表日期: 2010-08-01
DOI: 10.1016/j.jpba.2010.01.023
卷: 52, 期:4, 页:446-451
收录类别: SCI
文章类型: Article
部门归属: 18
项目归属: 1803
产权排名: 1;1
WOS标题词: Science & Technology ;  Physical Sciences ;  Life Sciences & Biomedicine
类目[WOS]: Chemistry, Analytical ;  Pharmacology & Pharmacy
研究领域[WOS]: Chemistry ;  Pharmacology & Pharmacy
英文摘要: A novel method has been developed for the purification of aristolochic acids and aristololactams compounds from Aristolochia plants, a kind of typically toxic traditional Chinese medicine. In this method, Oligo (ethylene glycol) separation column which has "clustering function" for compounds in TCMs was used to produce the fractions containing the compounds with similar structures. A four-channel parallel preparative HPLC with C18 separation column was employed to purify the target compounds. The extraction sample of the blending of Radix Aristolochiae, Fructus Aristolochiae and Caulis Aristolochiae Manshuriensis was used to develop the method. Then, four aristolochic acids and three aristololactams were obtained using this method and the chemical identification was confirmed by Q-TOF-MS, (1)H NMR and (13)C NMR. Thus, this method can deal with more than one traditional Chinese medicine simultaneously. Additionally, the results demonstrated that this method was an effective way to purify target compounds selectively from TCMs. (C) 2010 Elsevier B.V. All rights reserved.
关键词[WOS]: PERFORMANCE LIQUID-CHROMATOGRAPHY ;  OLIGO(ETHYLENE GLYCOL) ;  STATIONARY-PHASE ;  MEDICINAL-PLANTS ;  CONSTITUENTS ;  DERIVATIVES ;  ALKALOIDS ;  ANALOGS ;  CLICK ;  STEM
语种: 英语
原文出处: 查看原文
WOS记录号: WOS:000276057300004
Citation statistics: 
内容类型: 期刊论文
URI标识: http://cas-ir.dicp.ac.cn/handle/321008/103077
Appears in Collections:中国科学院大连化学物理研究所_期刊论文

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作者单位: 1.Chinese Acad Sci, Dalian Inst Chem Phys, Key Lab Separat Sci Analyt Chem, Dalian 116023, Peoples R China
2.Germantown Acad, Ft Washington, PA 19034 USA

Recommended Citation:
Zhang, Jing,Xiao, Yuansheng,Feng, Jiatao,et al. Selectively preparative purification of aristolochic acids and aristololactams from Aristolochia plants[J]. JOURNAL OF PHARMACEUTICAL AND BIOMEDICAL ANALYSIS,2010,52(4):446-451.
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