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Selectively preparative purification of aristolochic acids and aristololactams from Aristolochia plants
Zhang, Jing1; Xiao, Yuansheng1; Feng, Jiatao1; Wu, Sophia L.2; Xue, Xingya1; Zhang, Xiuli1; Liang, Xinmiao1; Xiao YS(肖远胜); Zhang XL(张秀莉)
关键词Oligo (Ethylene Glycol) Preparative Hplc Auto-purification Factory Aristolochic Acids Aristololactams
刊名JOURNAL OF PHARMACEUTICAL AND BIOMEDICAL ANALYSIS
2010-08-01
DOI10.1016/j.jpba.2010.01.023
52期:4页:446-451
收录类别SCI
文章类型Article
部门归属18
项目归属1803
产权排名1;1
WOS标题词Science & Technology ; Physical Sciences ; Life Sciences & Biomedicine
类目[WOS]Chemistry, Analytical ; Pharmacology & Pharmacy
研究领域[WOS]Chemistry ; Pharmacology & Pharmacy
关键词[WOS]PERFORMANCE LIQUID-CHROMATOGRAPHY ; OLIGO(ETHYLENE GLYCOL) ; STATIONARY-PHASE ; MEDICINAL-PLANTS ; CONSTITUENTS ; DERIVATIVES ; ALKALOIDS ; ANALOGS ; CLICK ; STEM
英文摘要A novel method has been developed for the purification of aristolochic acids and aristololactams compounds from Aristolochia plants, a kind of typically toxic traditional Chinese medicine. In this method, Oligo (ethylene glycol) separation column which has "clustering function" for compounds in TCMs was used to produce the fractions containing the compounds with similar structures. A four-channel parallel preparative HPLC with C18 separation column was employed to purify the target compounds. The extraction sample of the blending of Radix Aristolochiae, Fructus Aristolochiae and Caulis Aristolochiae Manshuriensis was used to develop the method. Then, four aristolochic acids and three aristololactams were obtained using this method and the chemical identification was confirmed by Q-TOF-MS, (1)H NMR and (13)C NMR. Thus, this method can deal with more than one traditional Chinese medicine simultaneously. Additionally, the results demonstrated that this method was an effective way to purify target compounds selectively from TCMs. (C) 2010 Elsevier B.V. All rights reserved.
语种英语
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WOS记录号WOS:000276057300004
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文献类型期刊论文
条目标识符http://cas-ir.dicp.ac.cn/handle/321008/103077
专题中国科学院大连化学物理研究所
通讯作者Xiao YS(肖远胜); Zhang XL(张秀莉)
作者单位1.Chinese Acad Sci, Dalian Inst Chem Phys, Key Lab Separat Sci Analyt Chem, Dalian 116023, Peoples R China
2.Germantown Acad, Ft Washington, PA 19034 USA
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Zhang, Jing,Xiao, Yuansheng,Feng, Jiatao,et al. Selectively preparative purification of aristolochic acids and aristololactams from Aristolochia plants[J]. JOURNAL OF PHARMACEUTICAL AND BIOMEDICAL ANALYSIS,2010,52(4):446-451.
APA Zhang, Jing.,Xiao, Yuansheng.,Feng, Jiatao.,Wu, Sophia L..,Xue, Xingya.,...&张秀莉.(2010).Selectively preparative purification of aristolochic acids and aristololactams from Aristolochia plants.JOURNAL OF PHARMACEUTICAL AND BIOMEDICAL ANALYSIS,52(4),446-451.
MLA Zhang, Jing,et al."Selectively preparative purification of aristolochic acids and aristololactams from Aristolochia plants".JOURNAL OF PHARMACEUTICAL AND BIOMEDICAL ANALYSIS 52.4(2010):446-451.
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