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Selectively preparative purification of aristolochic acids and aristololactams from Aristolochia plants
Zhang, Jing1; Xiao, Yuansheng1; Feng, Jiatao1; Wu, Sophia L.2; Xue, Xingya1; Zhang, Xiuli1; Liang, Xinmiao1; Xiao YS(肖远胜); Zhang XL(张秀莉)
KeywordOligo (Ethylene Glycol) Preparative Hplc Auto-purification Factory Aristolochic Acids Aristololactams
Source PublicationJOURNAL OF PHARMACEUTICAL AND BIOMEDICAL ANALYSIS
2010-08-01
DOI10.1016/j.jpba.2010.01.023
Volume52Issue:4Pages:446-451
Indexed BySCI
SubtypeArticle
Department18
Funding Project1803
Contribution Rank1;1
WOS HeadingsScience & Technology ; Physical Sciences ; Life Sciences & Biomedicine
WOS SubjectChemistry, Analytical ; Pharmacology & Pharmacy
WOS Research AreaChemistry ; Pharmacology & Pharmacy
WOS KeywordPERFORMANCE LIQUID-CHROMATOGRAPHY ; OLIGO(ETHYLENE GLYCOL) ; STATIONARY-PHASE ; MEDICINAL-PLANTS ; CONSTITUENTS ; DERIVATIVES ; ALKALOIDS ; ANALOGS ; CLICK ; STEM
AbstractA novel method has been developed for the purification of aristolochic acids and aristololactams compounds from Aristolochia plants, a kind of typically toxic traditional Chinese medicine. In this method, Oligo (ethylene glycol) separation column which has "clustering function" for compounds in TCMs was used to produce the fractions containing the compounds with similar structures. A four-channel parallel preparative HPLC with C18 separation column was employed to purify the target compounds. The extraction sample of the blending of Radix Aristolochiae, Fructus Aristolochiae and Caulis Aristolochiae Manshuriensis was used to develop the method. Then, four aristolochic acids and three aristololactams were obtained using this method and the chemical identification was confirmed by Q-TOF-MS, (1)H NMR and (13)C NMR. Thus, this method can deal with more than one traditional Chinese medicine simultaneously. Additionally, the results demonstrated that this method was an effective way to purify target compounds selectively from TCMs. (C) 2010 Elsevier B.V. All rights reserved.
Language英语
URL查看原文
WOS IDWOS:000276057300004
Citation statistics
Cited Times:11[WOS]   [WOS Record]     [Related Records in WOS]
Document Type期刊论文
Identifierhttp://cas-ir.dicp.ac.cn/handle/321008/103077
Collection中国科学院大连化学物理研究所
Corresponding AuthorXiao YS(肖远胜); Zhang XL(张秀莉)
Affiliation1.Chinese Acad Sci, Dalian Inst Chem Phys, Key Lab Separat Sci Analyt Chem, Dalian 116023, Peoples R China
2.Germantown Acad, Ft Washington, PA 19034 USA
Recommended Citation
GB/T 7714
Zhang, Jing,Xiao, Yuansheng,Feng, Jiatao,et al. Selectively preparative purification of aristolochic acids and aristololactams from Aristolochia plants[J]. JOURNAL OF PHARMACEUTICAL AND BIOMEDICAL ANALYSIS,2010,52(4):446-451.
APA Zhang, Jing.,Xiao, Yuansheng.,Feng, Jiatao.,Wu, Sophia L..,Xue, Xingya.,...&张秀莉.(2010).Selectively preparative purification of aristolochic acids and aristololactams from Aristolochia plants.JOURNAL OF PHARMACEUTICAL AND BIOMEDICAL ANALYSIS,52(4),446-451.
MLA Zhang, Jing,et al."Selectively preparative purification of aristolochic acids and aristololactams from Aristolochia plants".JOURNAL OF PHARMACEUTICAL AND BIOMEDICAL ANALYSIS 52.4(2010):446-451.
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