中国科学院大连化学物理研究所机构知识库
Advanced  
DICP OpenIR  > 中国科学院大连化学物理研究所  > 期刊论文
题名: Quantitative characterization of membrane formation process of alginate-chitosan microcapsules by GPC
作者: Yu, Weiting1;  Lin, Junzhang1;  Liu, Xiudong2;  Xie, Hongguo1;  Zhao, Wei1;  Ma, Xiaojun1
通讯作者: 马小军
关键词: Alginate-chitosan microcapsule ;  Membrane formation process ;  Quantitative characterization ;  Gel permeation chromatography
刊名: JOURNAL OF MEMBRANE SCIENCE
发表日期: 2010-01-15
DOI: 10.1016/j.memsci.2009.09.049
卷: 346, 期:2, 页:296-301
收录类别: SCI
文章类型: Article
部门归属: 18
项目归属: 1802
产权排名: 1;1
WOS标题词: Science & Technology ;  Technology ;  Physical Sciences
类目[WOS]: Engineering, Chemical ;  Polymer Science
研究领域[WOS]: Engineering ;  Polymer Science
英文摘要: The semi-permeable membrane of alginate-chitosain (AC) microcapsules has been proven important to control the microcapsule stability and selective substance diffusion rate. Therefore, a novel and operable methodology based on gel permeation chromatography (GPC) was established for quantitative characterization of the membrane formation process, so as to provide guidance on performance improvement of AC microcapsules in biomedical applications. Not only the molecular weight (M(w)) and its distribution of chitosan can be obtained by GPC, but also the area integral of molecular weight peaks can be linearly correlated to chitosan concentration in certain range. The dynamic membrane formation process was then obtained by quantitatively analyzing reaction amount of chitosam with time, which showed that for chitosan molecules with wide Mw distribution, only parts of molecules bind with alginate to form microcapsule membrane. Moreover, the contribution of chitosan molecules participating in the membrane formation process was also different. These new findings, therefore, are helpful for adjusting and controlling the membrane formation process and properties of microcapsule membrane. (C) 2009 Elsevier B.V. All rights reserved.
关键词[WOS]: OLIGOCHITOSAN MICROCAPSULES ;  EXCLUSION CHROMATOGRAPHY ;  INTESTINAL DELIVERY ;  PERMEABILITY
语种: 英语
原文出处: 查看原文
WOS记录号: WOS:000273107400009
Citation statistics: 
内容类型: 期刊论文
URI标识: http://cas-ir.dicp.ac.cn/handle/321008/103105
Appears in Collections:中国科学院大连化学物理研究所_期刊论文

Files in This Item:

There are no files associated with this item.


作者单位: 1.Chinese Acad Sci, Dalian Inst Chem Phys, Lab Biomed Mat Engn, Dalian 116023, Peoples R China
2.Dalian Univ Technol, Coll Environm & Chem Engn, Dalian 116622, Peoples R China

Recommended Citation:
Yu, Weiting,Lin, Junzhang,Liu, Xiudong,et al. Quantitative characterization of membrane formation process of alginate-chitosan microcapsules by GPC[J]. JOURNAL OF MEMBRANE SCIENCE,2010,346(2):296-301.
Service
 Recommend this item
 Sava as my favorate item
 Show this item's statistics
 Export Endnote File
Google Scholar
 Similar articles in Google Scholar
 [Yu, Weiting]'s Articles
 [Lin, Junzhang]'s Articles
 [Liu, Xiudong]'s Articles
CSDL cross search
 Similar articles in CSDL Cross Search
 [Yu, Weiting]‘s Articles
 [Lin, Junzhang]‘s Articles
 [Liu, Xiudong]‘s Articles
Related Copyright Policies
Null
Social Bookmarking
  Add to CiteULike  Add to Connotea  Add to Del.icio.us  Add to Digg  Add to Reddit 
所有评论 (0)
暂无评论
 
评注功能仅针对注册用户开放,请您登录
您对该条目有什么异议,请填写以下表单,管理员会尽快联系您。
内 容:
Email:  *
单位:
验证码:   刷新
您在IR的使用过程中有什么好的想法或者建议可以反馈给我们。
标 题:
 *
内 容:
Email:  *
验证码:   刷新

Items in IR are protected by copyright, with all rights reserved, unless otherwise indicated.

 

 

Valid XHTML 1.0!
Powered by CSpace