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Quantitative characterization of membrane formation process of alginate-chitosan microcapsules by GPC
Yu, Weiting1; Lin, Junzhang1; Liu, Xiudong2; Xie, Hongguo1; Zhao, Wei1; Ma, Xiaojun1; Ma XJ(马小军)
关键词Alginate-chitosan Microcapsule Membrane Formation Process Quantitative Characterization Gel Permeation Chromatography
刊名JOURNAL OF MEMBRANE SCIENCE
2010-01-15
DOI10.1016/j.memsci.2009.09.049
346期:2页:296-301
收录类别SCI
文章类型Article
部门归属18
项目归属1802
产权排名1;1
WOS标题词Science & Technology ; Technology ; Physical Sciences
类目[WOS]Engineering, Chemical ; Polymer Science
研究领域[WOS]Engineering ; Polymer Science
关键词[WOS]OLIGOCHITOSAN MICROCAPSULES ; EXCLUSION CHROMATOGRAPHY ; INTESTINAL DELIVERY ; PERMEABILITY
英文摘要The semi-permeable membrane of alginate-chitosain (AC) microcapsules has been proven important to control the microcapsule stability and selective substance diffusion rate. Therefore, a novel and operable methodology based on gel permeation chromatography (GPC) was established for quantitative characterization of the membrane formation process, so as to provide guidance on performance improvement of AC microcapsules in biomedical applications. Not only the molecular weight (M(w)) and its distribution of chitosan can be obtained by GPC, but also the area integral of molecular weight peaks can be linearly correlated to chitosan concentration in certain range. The dynamic membrane formation process was then obtained by quantitatively analyzing reaction amount of chitosam with time, which showed that for chitosan molecules with wide Mw distribution, only parts of molecules bind with alginate to form microcapsule membrane. Moreover, the contribution of chitosan molecules participating in the membrane formation process was also different. These new findings, therefore, are helpful for adjusting and controlling the membrane formation process and properties of microcapsule membrane. (C) 2009 Elsevier B.V. All rights reserved.
语种英语
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WOS记录号WOS:000273107400009
引用统计
被引频次:21[WOS]   [WOS记录]     [WOS相关记录]
文献类型期刊论文
条目标识符http://cas-ir.dicp.ac.cn/handle/321008/103105
专题中国科学院大连化学物理研究所
通讯作者Ma XJ(马小军)
作者单位1.Chinese Acad Sci, Dalian Inst Chem Phys, Lab Biomed Mat Engn, Dalian 116023, Peoples R China
2.Dalian Univ Technol, Coll Environm & Chem Engn, Dalian 116622, Peoples R China
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Yu, Weiting,Lin, Junzhang,Liu, Xiudong,et al. Quantitative characterization of membrane formation process of alginate-chitosan microcapsules by GPC[J]. JOURNAL OF MEMBRANE SCIENCE,2010,346(2):296-301.
APA Yu, Weiting.,Lin, Junzhang.,Liu, Xiudong.,Xie, Hongguo.,Zhao, Wei.,...&马小军.(2010).Quantitative characterization of membrane formation process of alginate-chitosan microcapsules by GPC.JOURNAL OF MEMBRANE SCIENCE,346(2),296-301.
MLA Yu, Weiting,et al."Quantitative characterization of membrane formation process of alginate-chitosan microcapsules by GPC".JOURNAL OF MEMBRANE SCIENCE 346.2(2010):296-301.
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