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题名: Hydro-spinning: A novel technology for making alginate/chitosan fibrous scaffold
作者: Wang, Jian-Zheng1, 2;  Huang, Xiao-Bo1, 2;  Xiao, Jing1, 2;  Yu, Wei-Ting1;  Wang, Wei1;  Xie, Wei-Yang1;  Zhang, Ying1;  Ma, Xiao-Jun1
通讯作者: 马小军
关键词: hydro-spinning ;  alginate ;  chitosan ;  fiber ;  polyelectrolyte complex (PEC)
刊名: JOURNAL OF BIOMEDICAL MATERIALS RESEARCH PART A
发表日期: 2010-06-01
DOI: 10.1002/jbm.a.32590
卷: 93A, 期:3, 页:910-919
收录类别: SCI
文章类型: Article
部门归属: 18
项目归属: 1802
产权排名: 1;1
WOS标题词: Science & Technology ;  Technology
类目[WOS]: Engineering, Biomedical ;  Materials Science, Biomaterials
研究领域[WOS]: Engineering ;  Materials Science
英文摘要: Alginate/chitosan polyelectrolyte complex (PEC) hybrid fibers are promising materials for scaffold-making in tissue engineering. In this study, a new method termed "hydro-spinning" was developed to make alginate/chitosan hybrid fibers. In hydro-spinning, a chitosan solution was pumped into a flowing sodium alginate solution and sheared into streamlines. These elongated streamlines subsequently transformed into alginate/chitosan PEC ribbon-like fibers before breaking up into pieces. Average diameter and chitosan content of the fibers correlated positively with the chitosan concentration used in spinning. These hybrid fibers showed a high water-absorbability of around 50-fold to 60-fold of water to their dry weight and could retain their integrity after saturation in minimum essential medium (MEM) medium for 30 days. In vitro culture experiments demonstrated that these fibers were able to support the three-dimensional growth of MCF-7, suggesting the potential applications of these fibers in biomedical and bioengineering fields such as tissue engineering. (C) 2009 Wiley Periodicals, Inc. J Biomed Mater Res 93A: 910-919, 2010
关键词[WOS]: EXTENSIONAL FLOW ;  SODIUM ALGINATE ;  SHEAR-FLOW ;  CHITOSAN ;  FIBERS ;  NANOFIBERS ;  MORPHOLOGY ;  VISCOSITY ;  DYNAMICS ;  OXIDE)
语种: 英语
原文出处: 查看原文
WOS记录号: WOS:000276916200011
Citation statistics: 
内容类型: 期刊论文
URI标识: http://cas-ir.dicp.ac.cn/handle/321008/103127
Appears in Collections:中国科学院大连化学物理研究所_期刊论文

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作者单位: 1.Chinese Acad Sci, Dalian Inst Chem Phys, Lab Biomed Mat Engn, Dalian 116023, Peoples R China
2.Chinese Acad Sci, Grad Sch, Beijing 100039, Peoples R China

Recommended Citation:
Wang, Jian-Zheng,Huang, Xiao-Bo,Xiao, Jing,et al. Hydro-spinning: A novel technology for making alginate/chitosan fibrous scaffold[J]. JOURNAL OF BIOMEDICAL MATERIALS RESEARCH PART A,2010,93A(3):910-919.
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