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Preparation of polyamine-functionalized copper specific adsorbents for selective adsorption of copper
Yu, Zhiyuan; Wu, Ren'an; Wu, Minghuo; Zhao, Liang; Li, Ruibin; Zou, Hanfa; Zou HF(邹汉法)
KeywordMicrospheres Adsorbent Copper Wilson's Disease Triethylenetetramine Tetraethylenepentamine
Source PublicationCOLLOIDS AND SURFACES B-BIOINTERFACES
2010-07-01
ISSN0927-7765
DOI10.1016/j.colsurfb.2010.03.004
Volume78Issue:2Pages:222-228
Indexed BySCI
SubtypeArticle
Department18
Funding Project1809
Contribution Rank1;1
WOS HeadingsScience & Technology ; Life Sciences & Biomedicine ; Physical Sciences ; Technology
WOS SubjectBiophysics ; Chemistry, Physical ; Materials Science, Biomaterials
WOS Research AreaBiophysics ; Chemistry ; Materials Science
WOS KeywordINORGANIC COMPLEX COMPOUNDS ; HUMAN SERUM-ALBUMIN ; WILSONS-DISEASE ; LIVER-TRANSPLANTATION ; POLYDENTATE GROUPS ; BINDING ; ION ; TRIETHYLENETETRAMINE ; DIALYSIS ; AFFINITY
AbstractThe level of serum free copper is greatly elevated in Wilson's disease. For patients with acute Wilson's disease, liver transplantation is the only lifesaving treatment. Plasma exchange or albumin dialysis is often used as a bridge to liver transplantation to maintain a stable clinical status for patients. Hemoperfusion is another effective therapy in removing toxins from the plasma. However, hemoperfusion has not been reported to remove copper due to lack of copper specific adsorbent. In this work, copper chelating agents, triethylenetetramine and tetraethylenepentamine, were covalently immobilized onto macroporous poly(glycidyl methacrylate-co-trimethylolpropane trimethacrylate) microspheres to prepare copper specific adsorbents. The resulting adsorbents demonstrated good adsorption capacities of 63.44 and 58.48 mg/g, respectively, for Cu(2+) ion. Additionally, with the interference of other metal ions such as Fe(2+), Mg(2+), Zn(2+) and Ca(2+), the prepared copper adsorbents still demonstrated good specificity toward Cu(2+) ion. These results indicate that the adsorbents are promising adsorbents in hemoperfusion therapy for selective removal of copper for patients with severe Wilson's disease. (C) 2010 Elsevier B.V. All rights reserved.
Language英语
URL查看原文
WOS IDWOS:000278167100011
Citation statistics
Cited Times:14[WOS]   [WOS Record]     [Related Records in WOS]
Document Type期刊论文
Identifierhttp://cas-ir.dicp.ac.cn/handle/321008/103135
Collection中国科学院大连化学物理研究所
Corresponding AuthorZou HF(邹汉法)
AffiliationChinese Acad Sci, Dalian Inst Chem Phys, Natl Chromatog R&A Ctr, CAS Key Lab Separat Sci Analyt Chem, Dalian 116023, Peoples R China
Recommended Citation
GB/T 7714
Yu, Zhiyuan,Wu, Ren'an,Wu, Minghuo,et al. Preparation of polyamine-functionalized copper specific adsorbents for selective adsorption of copper[J]. COLLOIDS AND SURFACES B-BIOINTERFACES,2010,78(2):222-228.
APA Yu, Zhiyuan.,Wu, Ren'an.,Wu, Minghuo.,Zhao, Liang.,Li, Ruibin.,...&邹汉法.(2010).Preparation of polyamine-functionalized copper specific adsorbents for selective adsorption of copper.COLLOIDS AND SURFACES B-BIOINTERFACES,78(2),222-228.
MLA Yu, Zhiyuan,et al."Preparation of polyamine-functionalized copper specific adsorbents for selective adsorption of copper".COLLOIDS AND SURFACES B-BIOINTERFACES 78.2(2010):222-228.
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