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题名: Preparation of polyamine-functionalized copper specific adsorbents for selective adsorption of copper
作者: Yu, Zhiyuan1;  Wu, Ren'an1;  Wu, Minghuo1;  Zhao, Liang1;  Li, Ruibin1;  Zou, Hanfa1
通讯作者: 邹汉法
关键词: Microspheres ;  Adsorbent ;  Copper ;  Wilson's disease ;  Triethylenetetramine ;  Tetraethylenepentamine
刊名: COLLOIDS AND SURFACES B-BIOINTERFACES
发表日期: 2010-07-01
DOI: 10.1016/j.colsurfb.2010.03.004
卷: 78, 期:2, 页:222-228
收录类别: SCI
文章类型: Article
部门归属: 18
项目归属: 1809
产权排名: 1;1
WOS标题词: Science & Technology ;  Life Sciences & Biomedicine ;  Physical Sciences ;  Technology
类目[WOS]: Biophysics ;  Chemistry, Physical ;  Materials Science, Biomaterials
研究领域[WOS]: Biophysics ;  Chemistry ;  Materials Science
英文摘要: The level of serum free copper is greatly elevated in Wilson's disease. For patients with acute Wilson's disease, liver transplantation is the only lifesaving treatment. Plasma exchange or albumin dialysis is often used as a bridge to liver transplantation to maintain a stable clinical status for patients. Hemoperfusion is another effective therapy in removing toxins from the plasma. However, hemoperfusion has not been reported to remove copper due to lack of copper specific adsorbent. In this work, copper chelating agents, triethylenetetramine and tetraethylenepentamine, were covalently immobilized onto macroporous poly(glycidyl methacrylate-co-trimethylolpropane trimethacrylate) microspheres to prepare copper specific adsorbents. The resulting adsorbents demonstrated good adsorption capacities of 63.44 and 58.48 mg/g, respectively, for Cu(2+) ion. Additionally, with the interference of other metal ions such as Fe(2+), Mg(2+), Zn(2+) and Ca(2+), the prepared copper adsorbents still demonstrated good specificity toward Cu(2+) ion. These results indicate that the adsorbents are promising adsorbents in hemoperfusion therapy for selective removal of copper for patients with severe Wilson's disease. (C) 2010 Elsevier B.V. All rights reserved.
关键词[WOS]: INORGANIC COMPLEX COMPOUNDS ;  HUMAN SERUM-ALBUMIN ;  WILSONS-DISEASE ;  LIVER-TRANSPLANTATION ;  POLYDENTATE GROUPS ;  BINDING ;  ION ;  TRIETHYLENETETRAMINE ;  DIALYSIS ;  AFFINITY
语种: 英语
原文出处: 查看原文
WOS记录号: WOS:000278167100011
Citation statistics: 
内容类型: 期刊论文
URI标识: http://cas-ir.dicp.ac.cn/handle/321008/103135
Appears in Collections:中国科学院大连化学物理研究所_期刊论文

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作者单位: 1.Chinese Acad Sci, Dalian Inst Chem Phys, Natl Chromatog R&A Ctr, CAS Key Lab Separat Sci Analyt Chem, Dalian 116023, Peoples R China

Recommended Citation:
Yu, Zhiyuan,Wu, Ren'an,Wu, Minghuo,et al. Preparation of polyamine-functionalized copper specific adsorbents for selective adsorption of copper[J]. COLLOIDS AND SURFACES B-BIOINTERFACES,2010,78(2):222-228.
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