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Preparation of polyamine-functionalized copper specific adsorbents for selective adsorption of copper
Yu, Zhiyuan; Wu, Ren'an; Wu, Minghuo; Zhao, Liang; Li, Ruibin; Zou, Hanfa; Zou HF(邹汉法)
关键词Microspheres Adsorbent Copper Wilson's Disease Triethylenetetramine Tetraethylenepentamine
刊名COLLOIDS AND SURFACES B-BIOINTERFACES
2010-07-01
ISSN0927-7765
DOI10.1016/j.colsurfb.2010.03.004
78期:2页:222-228
收录类别SCI
文章类型Article
部门归属18
项目归属1809
产权排名1;1
WOS标题词Science & Technology ; Life Sciences & Biomedicine ; Physical Sciences ; Technology
类目[WOS]Biophysics ; Chemistry, Physical ; Materials Science, Biomaterials
研究领域[WOS]Biophysics ; Chemistry ; Materials Science
关键词[WOS]INORGANIC COMPLEX COMPOUNDS ; HUMAN SERUM-ALBUMIN ; WILSONS-DISEASE ; LIVER-TRANSPLANTATION ; POLYDENTATE GROUPS ; BINDING ; ION ; TRIETHYLENETETRAMINE ; DIALYSIS ; AFFINITY
英文摘要The level of serum free copper is greatly elevated in Wilson's disease. For patients with acute Wilson's disease, liver transplantation is the only lifesaving treatment. Plasma exchange or albumin dialysis is often used as a bridge to liver transplantation to maintain a stable clinical status for patients. Hemoperfusion is another effective therapy in removing toxins from the plasma. However, hemoperfusion has not been reported to remove copper due to lack of copper specific adsorbent. In this work, copper chelating agents, triethylenetetramine and tetraethylenepentamine, were covalently immobilized onto macroporous poly(glycidyl methacrylate-co-trimethylolpropane trimethacrylate) microspheres to prepare copper specific adsorbents. The resulting adsorbents demonstrated good adsorption capacities of 63.44 and 58.48 mg/g, respectively, for Cu(2+) ion. Additionally, with the interference of other metal ions such as Fe(2+), Mg(2+), Zn(2+) and Ca(2+), the prepared copper adsorbents still demonstrated good specificity toward Cu(2+) ion. These results indicate that the adsorbents are promising adsorbents in hemoperfusion therapy for selective removal of copper for patients with severe Wilson's disease. (C) 2010 Elsevier B.V. All rights reserved.
语种英语
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WOS记录号WOS:000278167100011
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被引频次:14[WOS]   [WOS记录]     [WOS相关记录]
文献类型期刊论文
条目标识符http://cas-ir.dicp.ac.cn/handle/321008/103135
专题中国科学院大连化学物理研究所
通讯作者Zou HF(邹汉法)
作者单位Chinese Acad Sci, Dalian Inst Chem Phys, Natl Chromatog R&A Ctr, CAS Key Lab Separat Sci Analyt Chem, Dalian 116023, Peoples R China
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Yu, Zhiyuan,Wu, Ren'an,Wu, Minghuo,et al. Preparation of polyamine-functionalized copper specific adsorbents for selective adsorption of copper[J]. COLLOIDS AND SURFACES B-BIOINTERFACES,2010,78(2):222-228.
APA Yu, Zhiyuan.,Wu, Ren'an.,Wu, Minghuo.,Zhao, Liang.,Li, Ruibin.,...&邹汉法.(2010).Preparation of polyamine-functionalized copper specific adsorbents for selective adsorption of copper.COLLOIDS AND SURFACES B-BIOINTERFACES,78(2),222-228.
MLA Yu, Zhiyuan,et al."Preparation of polyamine-functionalized copper specific adsorbents for selective adsorption of copper".COLLOIDS AND SURFACES B-BIOINTERFACES 78.2(2010):222-228.
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