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Polyhedral Oligomeric Silsesquioxane as a Cross-linker for Preparation of Inorganic-Organic Hybrid Monolithic Columns
Wu, Minghuo1,2; Wu, Ren'an1; Li, Ruibing1,2; Qin, Hongqiang1,2; Dong, Jing1; Zhang, Zhenbin1,2; Zou, Hanfa1; Zou HF(邹汉法)
Source PublicationANALYTICAL CHEMISTRY
2010-07-01
ISSN0003-2700
DOI10.1021/ac1003147
Volume82Issue:13Pages:5447-5454
Indexed BySCI
SubtypeArticle
Department18
Funding Project1809
Contribution Rank1;1
WOS HeadingsScience & Technology ; Physical Sciences
WOS SubjectChemistry, Analytical
WOS Research AreaChemistry
WOS KeywordPERFORMANCE LIQUID-CHROMATOGRAPHY ; CAPILLARY ELECTROCHROMATOGRAPHY ; STATIONARY PHASES ; SILICA CAPILLARIES ; SEPARATION ; POLYMERS ; NANOCOMPOSITES ; COPOLYMERS ; PROTEINS ; MONOMER
AbstractAn inorganic-organic hybrid monolithic capillary column was synthesized via thermal free radical copolymerization within the confines of a capillary using a polyhedral oligomeric silsesquioxane (POSS) reagent as the inorganic-organic hybrid cross-linker and a synthesized long carbon chain quaternary ammonium methacrylate of N-(2-(methacryloyloxy)ethyl)-dimethy-loctadecylammonium bromide (MDOAB) as the organic monomer. The preparation process was as simple as pure organic polymer-based monolithic columns instead of using POSS as the nanosized inorganic-organic hybrid blocks (cross-linker) of the monolithic matrix. The pore properties and permeability could be tuned by the composition of the polymerization mixture. The characterization and evaluation results indicated that the synthesized MDOA-POSS hybrid monolith possessed the merits of organic polymer-based monoliths and silica-based monoliths with good mechanical and pH (pH 1-11) stabilities, which may be attributed to the incorporation of the rigid nanosized silica core of POSS. Column efficiencies of 223 000 and 50 000 N/m were observed in capillary electro-driven chromatography (CEC) and mu-HPLC, respectively. Peptides and standard proteins were baseline separated by this hybrid column in CEC and mu-HPLC, respectively, as well. The separation of bovine serum albumin (BSA) tryptic digest was also attempted to show its potential application in proteome analysis.
Language英语
URL查看原文
WOS IDWOS:000279253300010
Citation statistics
Cited Times:106[WOS]   [WOS Record]     [Related Records in WOS]
Document Type期刊论文
Identifierhttp://cas-ir.dicp.ac.cn/handle/321008/103143
Collection中国科学院大连化学物理研究所
Corresponding AuthorZou HF(邹汉法)
Affiliation1.Chinese Acad Sci, Dalian Inst Chem Phys, Natl Chromatog R&A Ctr, CAS Key Lab Separat Sci Analyt Chem, Dalian 116023, Peoples R China
2.Chinese Acad Sci, Grad Sch, Beijing 100049, Peoples R China
Recommended Citation
GB/T 7714
Wu, Minghuo,Wu, Ren'an,Li, Ruibing,et al. Polyhedral Oligomeric Silsesquioxane as a Cross-linker for Preparation of Inorganic-Organic Hybrid Monolithic Columns[J]. ANALYTICAL CHEMISTRY,2010,82(13):5447-5454.
APA Wu, Minghuo.,Wu, Ren'an.,Li, Ruibing.,Qin, Hongqiang.,Dong, Jing.,...&邹汉法.(2010).Polyhedral Oligomeric Silsesquioxane as a Cross-linker for Preparation of Inorganic-Organic Hybrid Monolithic Columns.ANALYTICAL CHEMISTRY,82(13),5447-5454.
MLA Wu, Minghuo,et al."Polyhedral Oligomeric Silsesquioxane as a Cross-linker for Preparation of Inorganic-Organic Hybrid Monolithic Columns".ANALYTICAL CHEMISTRY 82.13(2010):5447-5454.
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